Tissue plasminogen activator-containing polyurethane surfaces for fibrinolytic activity

With the aim of minimizing thrombus formation in blood-contacting devices, tissue plasminogen activator (t-PA)-containing polyurethane (PU) materials have been developed. Cationic PU surfaces were prepared by grafting poly(dimethylaminoethyl methacrylate) and quaternizing the tertiary amino groups with iodomethane or 1,6-diiodohexane or α,α'-dichloro-p-xylene. The surfaces were characterized by water contact angles and X-ray photoelectron …