Proto-Oncogene Proteins c-bcl-2 Concept

subject area of

• Escherichia coliShiga toxins induce apoptosis in epithelial cells that is regulated by the Bcl-2 family  Journal Articles
• A phase I study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in solid tumor malignancies  Journal Articles
• A phase II study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in relapsed small cell lung cancer  Journal Articles
• A phase I–II study of oblimersen sodium (G3139, Genasense) in combination with doxorubicin in advanced hepatocellular carcinoma (NCI # 5798)  Journal Articles
• A pilot study of radiation-induced bystander effect in radio-adapting frogs at a radiologically contaminated site located on the chalk river laboratories property  Journal Articles
• ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes  Journal Articles
• Akt Is Activated in Response to an Apoptotic Signal  Journal Articles
• Alterations in Mitochondrial and Apoptosis‐regulating Gene Expression in Photodynamic Therapy‐resistant Variants of HT29 Colon Carcinoma Cells^¶  Journal Articles
• Apoptosis and other effects of radiation in normal human urothelial cells  Journal Articles
• Apoptosis is initiated in human keratinocytes exposed to signalling factors from microbeam irradiated cells  Journal Articles
• Apoptosis: embedded in membranes  Journal Articles
• Assembly of Bcl-2 into microsomal and outer mitochondrial membranes  Journal Articles
• BCL-2: the pendulum of the cell fate.  Journal Articles
• BH3-only proteins: Orchestrators of apoptosis  Journal Articles
• Bax Forms an Oligomer via Separate, Yet Interdependent, Surfaces  Journal Articles
• Bax Homodimerization Is Not Required for Bax to Accelerate Chemotherapy-induced Cell Death  Journal Articles
• Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis  Journal Articles
• Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator  Journal Articles
• Bcl-2 changes conformation to inhibit Bax oligomerization  Journal Articles
• Bcl-2 is an independent prognostic factor and adds to a biological model for predicting outcome in operable non-small cell lung cancer  Journal Articles
• Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.  Journal Articles
• Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts  Journal Articles
• Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line  Journal Articles
• Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2  Journal Articles
• Bystander effect induced changes in apoptosis related proteins and terminal differentiation inin vitromurine bladder cultures  Journal Articles
• Cannabidiol Protects Striatal Neurons by Attenuating Endoplasmic Reticulum Stress  Journal Articles
• Cigarette Smoke Exposure Leads to Follicle Loss via an Alternative Ovarian Cell Death Pathway in a Mouse Model  Journal Articles
• Communication of Radiation-Induced Signals in Vivo between DNA Repair Deficient and Proficient Medaka (Oryzias latipes)  Journal Articles
• Diagnosis of mitochondrial energy metabolism defects in tissue culture. Induction of MnSOD and bcl‐2 in mitochondria from patients with complex I (NADH‐CoQ reductase) deficiency  Journal Articles
• Differences in the Mechanisms of Proapoptotic BH3 Proteins Binding to Bcl-XL and Bcl-2 Quantified in Live MCF-7 Cells  Journal Articles
• Does immunointensity account for the differences in prognostic significance of Bcl-2 expression in non-small cell lung cancer?  Journal Articles
• Down‐regulated miRs specifically correlate with non‐cardial gastric cancers and Lauren's classification system  Journal Articles
• Drugs targeting Bcl-2 family members as an emerging strategy in cancer  Journal Articles
• During Apoptosis Bcl-2 Changes Membrane Topology at Both the Endoplasmic Reticulum and Mitochondria  Journal Articles
• Effect of Low Doses of Ionizing Radiation on Cells Cultured from the Hematopoietic Tissue of the Dublin Bay Prawn,Nephrops norvegicus  Journal Articles
• Effect of docetaxel (taxotere) on expression of radiation-induced lethal mutations in human cell lines  Journal Articles
• Effects of dietary folic acid supplementation on lactation performance and mammary epithelial cell development of dairy cows and its regulatory mechanism  Journal Articles
• Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells  Journal Articles
• Embedded together: The life and death consequences of interaction of the Bcl-2 family with membranes  Journal Articles
• Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event  Journal Articles
• Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins  Journal Articles
• Evidence for Multiple Mechanisms for Membrane Binding and Integration via Carboxyl-Terminal Insertion Sequences  Journal Articles
• Examining the Molecular Mechanism of Bcl-2 Family Proteins at Membranes by Fluorescence Spectroscopy  Journal Articles
• Expression of Lethal Mutations Is Suppressed in Neoplastically Transformed Cells and after Treatment of Normal Cells with Carcinogens  Journal Articles
• Expression of apoptosis-related proteins in thyroid tumors and thyroid carcinoma cell lines  Journal Articles
• Expression of delayed toxicity and lethal mutations in the progeny of human cells surviving exposure to radiation and other environmental mutagens  Conferences
• Expression of survivin and p16INK4a/Cdk6/pRB proteins and induction of apoptosis in response to radiation and cisplatin in meningioma cells  Journal Articles
• Flavopiridol Sensitivity of Cancer Cells Isolated from Ascites and Pleural Fluids  Journal Articles
• Further Investigation of the Response of Human Uroepithelium to Low Doses of Cobalt-60 Gamma Radiation  Journal Articles
• Gender differences in muscle inflammation after eccentric exercise  Journal Articles
• Gross thymic extract, Thymax, induces apoptosis in human breast cancer cells in vitro through the mitochondrial pathway.  Conferences
• Gut Mucosal Homeostasis and Cellular Mediators after Severe Thermal Trauma and the Effect of Insulin-Like Growth Factor-I in Combination with Insulin-Like Growth Factor Binding Protein-3  Journal Articles
• Identification of a hTid‐1 mutation which sensitizes gliomas to apoptosis  Journal Articles
• Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression  Journal Articles
• Immunohistochemical analysis of Bcl-2, Bcl-X, Mcl-1, and Bax in tumors of central and peripheral nervous system origin.  Journal Articles
• Induction of Mdm2 and enhancement of cell survival by bFGF  Journal Articles
• Induction of multiple PCR-SSCPE mobility shifts in exons in cultures of normal human urothelium exposed to low-dose gamma radiation  Journal Articles
• Inhibition of p53 Transcriptional Activity by Bcl-2 Requires Its Membrane-anchoring Domain  Journal Articles
• Interaction with a Membrane Surface Triggers a Reversible Conformational Change in Bax Normally Associated with Induction of Apoptosis  Journal Articles
• Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET  Journal Articles
• Ionizing Radiation Induces a Stress Response in Primary Cultures of Rainbow Trout Skin  Journal Articles
• Manganese Superoxide Dismutase Levels Are Elevated in a Proportion of Amyotrophic Lateral Sclerosis Patient Cell Lines  Journal Articles
• Mechanisms of Action of Bcl-2 Family Proteins  Journal Articles
• Medium from Irradiated Cells Induces Dose-Dependent Mitochondrial Changes and BCL2 Responses in Unirradiated Human Keratinocytes  Journal Articles
• Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis  Journal Articles
• Molecular Pathways: Leveraging the BCL-2 Interactome to Kill Cancer Cells—Mitochondrial Outer Membrane Permeabilization and Beyond  Journal Articles
• Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria  Journal Articles
• Outcomes of MYC‐associated lymphomas after R‐CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704  Journal Articles
• Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis  Journal Articles
• Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals  Journal Articles
• Raloxifene, a Mixed Estrogen Agonist/Antagonist, Induces Apoptosis through Cleavage of BAD in TSU-PR1 Human Cancer Cells  Journal Articles
• Regulating cell death at, on, and in membranes  Journal Articles
• Regulation of Acidification and Apoptosis by SHP-1 and Bcl-2  Journal Articles
• SBDS-deficient cells undergo accelerated apoptosis through the Fas-pathway  Journal Articles
• Shedding Light on Apoptosis at Subcellular Membranes  Journal Articles
• Small molecules reveal an alternative mechanism of Bax activation  Journal Articles
• Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells  Journal Articles
• Still embedded together binding to membranes regulates Bcl-2 protein interactions  Journal Articles
• Survival of human epithelial cells irradiated with cobalt 60 as microcolonies or single cells  Journal Articles
• Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf  Journal Articles
• The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2  Journal Articles
• The antiapoptotic effect of guanosine is mediated by the activation of the PI 3‐kinase/AKT/PKB pathway in cultured rat astrocytes  Journal Articles
• The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes  Journal Articles
• The effect of hepatocyte growth factor on gut mucosal apoptosis and proliferation, and cellular mediators after severe trauma  Journal Articles
• The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system  Journal Articles
• The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity  Journal Articles
• There is more to life and death than mitochondria: Bcl-2 proteins at the endoplasmic reticulum  Journal Articles
• Towards a biological staging model for operable non-small cell lung cancer  Journal Articles
• Variation in the expression of p53, c-myc, and bcl-2 oncoproteins in individual patient cultures of normal urothelium exposed to cobalt 60 gamma-rays and N-nitrosodiethanolamine.  Journal Articles
• miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer  Journal Articles