Journal article
Medium from Irradiated Cells Induces Dose-Dependent Mitochondrial Changes and BCL2 Responses in Unirradiated Human Keratinocytes
Abstract
Exposure of unirradiated human keratinocytes to irradiated cell conditioned medium (ICCM) is known to cause a cascade of events that leads to reproductive death and apoptosis. This study investigates the effect of ICCM on clonogenic survival, mitochondrial mass and BCL2 expression in unirradiated keratinocytes. Exposure to 5 mGy, 0.5 Gy and 5 Gy ICCM resulted in a significant decrease in clonogenic survival. Human keratinocytes incubated with …
Authors
Maguire P; Mothersill C; Seymour C; Lyng FM
Journal
Radiation Research, Vol. 163, No. 4, pp. 384–390
Publisher
Radiation Research Society
Publication Date
April 2005
DOI
10.1667/rr3325
ISSN
0033-7587