Journal article
Identification of a hTid‐1 mutation which sensitizes gliomas to apoptosis
Abstract
Human Tid-1 (hTid-1) is a DnaJ chaperone protein with homology to the Drosophila tumor suppressor Tid56. We report the first case of a tumor-associated mutation at the human TID1 locus, which was identified in the SF767 glioma cell line giving rise to aberrantly high levels of a hTid-1(L) mutant variant. In this study, we set out to determine whether this change in hTid-1 status influences the response of glioma cells to adenoviral …
Authors
Trentin GA; He Y; Wu DC; Tang D; Rozakis-Adcock M
Journal
FEBS Letters, Vol. 578, No. 3, pp. 323–330
Publisher
Wiley
Publication Date
December 17, 2004
DOI
10.1016/j.febslet.2004.11.034
ISSN
0014-5793
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAnimalsApoptosisBlotting, WesternCOS CellsCaspasesCell Line, TumorChlorocebus aethiopsCytochrome c GroupDrosophilaDrosophila ProteinsEnzyme ActivationGenes, Tumor SuppressorGenetic VariationGliomaHSP40 Heat-Shock ProteinsHeat-Shock ProteinsHumansInsect ProteinsMitochondriaMitochondrial ProteinsMolecular ChaperonesMolecular WeightMutationPropidiumProto-Oncogene Proteins c-bcl-2bcl-X Protein