Journal article
Chapter One Examining the Molecular Mechanism of Bcl-2 Family Proteins at Membranes by Fluorescence Spectroscopy
Abstract
The Bcl-2 family proteins control apoptosis by regulation of outer mitochondrial membrane permeabilization. Studying the Bcl-2 family is particularly difficult because the functional interactions that regulate apoptosis occur at or within intracellular membranes. Compared to other biophysical methods, fluorescence spectroscopy is well suited to study membrane-bound proteins as experiments can be performed with intact membranes and at protein …
Authors
Kale J; Chi X; Leber B; Andrews D
Journal
Methods in Enzymology, Vol. 544, , pp. 1–23
Publisher
Elsevier
Publication Date
2014
DOI
10.1016/b978-0-12-417158-9.00001-7
ISSN
0076-6879