Platelet Factor 4 Concept

subject area of

• A Spontaneous Prothrombotic Disorder Resembling Heparin-induced Thrombocytopenia  Academic Article
• A prospective study measuring the development of antibodies against platelet factor 4-heparin in healthy males after exposure to heparins  Academic Article
• Abnormal megakaryocyte development and platelet function in Nbeal2−/− mice  Academic Article
• Activation of platelets by sera containing igg1 heparin-dependent antibodies: an explanation for the predominance of the Fcγrlla “low responder” (his131) gene in patients with heparin-induced thrombocytopenia  Academic Article
• An Overview of the Heparin-Induced Thrombocytopenia Syndrome  Academic Article
• Anti-PF4/heparin antibodies and venous graft occlusion in postcoronary artery bypass surgery patients randomized to postoperative unfractionated heparin or fondaparinux thromboprophylaxis  Academic Article
• Anti-PF4/heparin antibody formation postorthopedic surgery thromboprophylaxis: the role of non-drug risk factors and evidence for a stoichiometry-based model of immunization  Academic Article
• Antiphospholipid and anti-PF4 antibodies: an association affecting anti-PF4/heparin assay analysis  Academic Article
• Anti–platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin  Academic Article
• Anti–protamine-heparin antibodies: incidence, clinical relevance, and pathogenesis  Academic Article
• Autoimmune heparin-induced thrombocytopenia  Academic Article
• B cells, PF4/heparin complexes, and complement  Academic Article
• Benefit and risk of heparin for maintaining peripheral venous catheters in neonates: a placebo-controlled trial  Academic Article
• Cellular immune responses to platelet factor 4 and heparin complexes in patients with heparin-induced thrombocytopenia  Academic Article
• Chemistry, Measurement, and Clinical Significance of Platelet Specific Proteins  Academic Article
• Clinical effectiveness of a Bayesian algorithm for the diagnosis and management of heparin-induced thrombocytopenia  Academic Article
• Clinical picture of heparin-induced thrombocytopenia (HIT) and its differentiation from non-HIT thrombocytopenia  Academic Article
• Clinical sample investigation (CSI) hematology: pinpointing the precise onset of heparin-induced thrombocytopenia (HIT)  Academic Article
• Close Approximation of Two Platelet Factor 4 Tetramers by Charge Neutralization Forms the Antigens Recognized by HIT Antibodies  Academic Article
• Combination of 4Ts score and PF4/H-PaGIA for diagnosis and management of heparin-induced thrombocytopenia: prospective cohort study  Academic Article
• Combined use of the high heparin step and optical density to optimize diagnostic sensitivity and specificity of an anti-PF4/heparin enzyme-immunoassay  Academic Article
• Confirmatory procedure and other maneuvers to assess pathogenicity of platelet factor 4 (PF4)-dependent antibodies – distinguishing "signal" from "noise"  Academic Article
• Delayed-Onset Heparin-Induced Thrombocytopenia and Cerebral Thrombosis after a Single Administration of Unfractionated Heparin  Academic Article
• Delayed-Onset Heparin-Induced Thrombocytopenia and Thrombosis  Academic Article
• Delayed-onset HIT caused by low-molecular-weight heparin manifesting during fondaparinux prophylaxis  Academic Article
• Development of a high-yield expression and purification system for platelet factor 4  Academic Article
• Diagnostic accuracy of IgG-specific versus polyspecific enzyme-linked immunoassays in heparin-induced thrombocytopenia: a systematic review and meta-analysis  Academic Article
• Distinguishing between anti-platelet factor 4/heparin antibodies that can and cannot cause heparin-induced thrombocytopenia  Academic Article
• Early-onset and persisting thrombocytopenia in post-cardiac surgery patients is rarely due to heparin-induced thrombocytopenia, even when antibody tests are positive  Academic Article
• Effect of anti-platelet factor-4/heparin antibody induction on early saphenous vein graft occlusion after coronary artery bypass surgery  Academic Article
• Evidence for thrombin binding to dermatan sulphate sites in the rabbit aorta subendothelium in vitro  Academic Article
• FcγRIIa proteolysis as a diagnostic biomarker for heparin-induced thrombocytopenia  Academic Article
• Fibrinogen proteolysis and platelet alpha-granule release in preeclampsia/eclampsia.  Academic Article
• Fondaparinux thromboprophylaxis-associated heparin-induced thrombocytopenia syndrome complicated by arterial thrombotic stroke  Academic Article
• Fondaparinux: does it cause HIT? can it treat HIT?  Academic Article
• Formation of anti–platelet factor 4/heparin antibodies after cardiac surgery: Influence of perioperative platelet activation, the inflammatory response, and histocompatibility leukocyte antigen status  Academic Article
• HEPARIN-INDUCED THROMBOCYTOPENIA: A Ten-Year Retrospective  Academic Article
• HITlights: A career perspective on heparin-induced thrombocytopenia  Academic Article
• Hemodialysis-Associated Acute Systemic Reactions and Heparin-Induced Thrombocytopenia  Academic Article
• Heparin-Induced Thrombocytopenia  Academic Article
• Heparin-Induced Thrombocytopenia  Academic Article
• Heparin-Induced Thrombocytopenia in Patients with Ventricular Assist Devices: Are New Prevention Strategies Required?  Academic Article
• Heparin-induced thrombocytopenia  Academic Article
• Heparin-induced thrombocytopenia - therapeutic concentrations of danaparoid, unlike fondaparinux and direct thrombin inhibitors, inhibit formation of platelet factor 4-heparin complexes  Academic Article
• Heparin-induced thrombocytopenia: A stoichiometry-based model to explain the differing immunogenicities of unfractionated heparin, low-molecular-weight heparin, and fondaparinux in different clinical settings  Academic Article
• Heparin-induced thrombocytopenia: a prospective study on the incidence, platelet-activating capacity and clinical significance of antiplatelet factor 4/heparin antibodies of the IgG, IgM, and IgA classes  Academic Article
• Heparin-induced thrombocytopenia: towards standardization of platelet factor 4/heparin antigen tests  Academic Article
• High sensitivity and specificity of an automated IgG-specific chemiluminescence immunoassay for diagnosis of HIT  Academic Article
• IV Immunoglobulin for Autoimmune Heparin-Induced Thrombocytopenia  Academic Article
• Immune heparin-induced thrombocytopenia can occur in patients receiving clopidogrel and aspirin  Academic Article
• Immunoglobulin G from patients with heparin-induced thrombocytopenia binds to a complex of heparin and platelet factor 4.  Academic Article
• Impact of the patient population on the risk for heparin-induced thrombocytopenia  Academic Article
• Improving Clinical Interpretation of the Anti-Platelet Factor 4/Heparin Enzyme-Linked Immunosorbent Assay for the Diagnosis of Heparin-Induced Thrombocytopenia Through the Use of Receiver Operating Characteristic Analysis, Stratum-Specific Likelihood Ratios, and Bayes Theorem  Academic Article
• In vivo platelet activation with in vitro hyperaggregability to arachidonic acid in renal allograft recipients.  Academic Article
• Incidence and clinical relevance of anti–platelet factor 4/heparin antibodies before cardiac surgery  Academic Article
• Increased Platelet Destruction  Academic Article
• Increased heparin clearance in experimental pulmonary embolism.  Academic Article
• Increased mortality in hemodialysis patients having specific antibodies to the platelet factor 4-heparin complex  Academic Article
• Intraglomerular localization of platelet related antigens, platelet factor 4 and beta-thromboglobulin in glomerulonephritis.  Academic Article
• Investigation of a platelet factor 4 polymorphism on the immune response in patients with heparin-induced thrombocytopenia  Academic Article
• Laboratory testing for heparin-induced thrombocytopenia.  Academic Article
• Laboratory testing for heparin-induced thrombocytopenia: a conceptual framework and implications for diagnosis  Academic Article
• Management of heparin-induced thrombocytopenia  Academic Article
• Measurement of platelet release substances in glomerulonephritis: A comparison of beta-thromboglobulin (β-TG), platelet factor 4 (PF4) and serotonin assays  Academic Article
• Neutralization of Heparin Activity  Academic Article
• New Approaches to the Diagnosis of Heparin-Induced Thrombocytopenia  Academic Article
• No significant improvement in diagnostic specificity of an anti-PF4/polyanion immunoassay with use of high heparin confirmatory procedure  Academic Article
• Nonheparin Anticoagulants for Heparin-Induced Thrombocytopenia  Academic Article
• Optical Densities Reduce Odds of Heparin-induced Thrombocytopenia Over-diagnosis  Academic Article
• PF4-dependent immunoassays and inferential detection of HIT antibodies  Academic Article
• Performance characteristics of a rapid assay for anti-PF4/heparin antibodies: the particle immunofiltration assay  Academic Article
• Performance characteristics of an automated latex immunoturbidimetric assay [HemosIL ® HIT-Ab (PF4-H) ] for the diagnosis of immune heparin-induced thrombocytopenia  Academic Article
• Plasma exchange to remove HIT antibodies: dissociation between enzyme-immunoassay and platelet activation test reactivities  Academic Article
• Platelet Activation Testing for Heparin-Induced Thrombocytopenia Antibodies  Academic Article
• Platelet count recovery and seroreversion in immune HIT despite continuation of heparin: further observations and literature review  Academic Article
• Platelet-Activating Antibodies Are Detectable at the Earliest Onset of Heparin-Induced Thrombocytopenia, With Implications for the Operating Characteristics of the Serotonin-Release Assay  Academic Article
• Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis  Academic Article
• Prevalence and Risk of Preexisting Heparin-Induced Thrombocytopenia Antibodies in Patients With Acute VTE  Academic Article
• Prevalence and clinical implications of anti-PF4/heparin antibodies in intensive care patients: a prospective observational study  Academic Article
• Prognostic importance of preoperative anti-PF4/heparin antibodies in patients undergoing cardiac surgery  Academic Article
• Prospective multicentre cohort study of heparin-induced thrombocytopenia in acute ischaemic stroke patients  Academic Article
• Protamine (heparin)-induced thrombocytopenia: a review of the serological and clinical features associated with anti-protamine/heparin antibodies  Academic Article
• Quantitative interpretation of optical density measurements using PF4-dependent enzyme-immunoassays  Academic Article
• Recognition, treatment, and prevention of heparin-induced thrombocytopenia: Review and update  Academic Article
• Studies of the anti–platelet factor 4/heparin immune response: adapting the enzyme-linked immunosorbent spot assay for detection of memory B cells against complex antigens  Academic Article
• Studies of the immune response in heparin-induced thrombocytopenia  Academic Article
• Studies of α-granule proteins in cultured human megakaryocytes  Academic Article
• Testing for Heparin-Induced Thrombocytopenia Antibodies  Academic Article
• Testing for heparin-induced thrombocytopenia: are we there yet?  Academic Article
• The Pathophysiology of Heparin-Induced Thrombocytopenia  Academic Article
• The effects of high-dose heparin on inflammatory and coagulation parameters following cardiopulmonary bypass  Academic Article
• The epitope specificity of heparin-induced thrombocytopenia  Academic Article
• The mechanism of action of thrombin inhibitors.  Academic Article
• The prevalence of antibodies to the platelet factor 4 -heparin complex and association with access thrombosis in patients on chronic hemodialysis  Academic Article
• The serological profile of early-onset and persisting post-cardiac surgery thrombocytopenia complicated by “true” heparin-induced thrombocytopenia  Academic Article
• The serological profile of fondaparinux-associated heparin-induced thrombocytopenia syndrome  Academic Article
• The temporal profile of the anti-PF4/heparin immune response  Academic Article
• The use of well-characterized sera for the assessment of new diagnostic enzyme-immunoassays for the diagnosis of heparin-induced thrombocytopenia  Academic Article
• Transient pseudothrombocytopenia associated with immune heparin-induced thrombocytopenia complicated by pulmonary embolism  Academic Article
• When is HIT Really HIT?  Academic Article