Platelet Factor 4 Concept

subject area of

• ABO O blood group as a risk factor for platelet reactivity in heparin-induced thrombocytopenia  Journal Articles
• A Spontaneous Prothrombotic Disorder Resembling Heparin-induced Thrombocytopenia  Journal Articles
• A comparative study of platelet factor 4‐enhanced platelet activation assays for the diagnosis of heparin‐induced thrombocytopenia  Journal Articles
• A prospective study measuring the development of antibodies against platelet factor 4–heparin in healthy males after exposure to heparins  Journal Articles
• Abnormal megakaryocyte development and platelet function in Nbeal2−/− mice  Journal Articles
• Activation of platelets by sera containing igg1 heparin-dependent antibodies: an explanation for the predominance of the Fcγrlla “low responder” (his131) gene in patients with heparin-induced thrombocytopenia  Journal Articles
• Adjunct Immune Globulin for Vaccine-Induced Immune Thrombotic Thrombocytopenia  Journal Articles
• An Overview of the Heparin-Induced Thrombocytopenia Syndrome  Journal Articles
• An international external quality assessment for laboratory diagnosis of heparin‐induced thrombocytopenia  Journal Articles
• Antibodies against platelet factor 4 and the risk of cerebral venous sinus thrombosis in patients with vaccine-induced immune thrombotic thrombocytopenia  Journal Articles
• Antibody Fingerprints Linking Adenoviral Anti-PF4 Disorders  Journal Articles
• Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia  Journal Articles
• Antiphospholipid and anti‐PF4 antibodies: an association affecting anti‐PF4/heparin assay analysis  Journal Articles
• Anti‐PF4/heparin antibodies and venous graft occlusion in postcoronary artery bypass surgery patients randomized to postoperative unfractionated heparin or fondaparinux thromboprophylaxis  Journal Articles
• Anti‐PF4/heparin antibody formation postorthopedic surgery thromboprophylaxis: the role of non‐drug risk factors and evidence for a stoichiometry‐based model of immunization  Journal Articles
• Anti–platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein  Journal Articles
• Anti–platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin  Journal Articles
• Anti–protamine-heparin antibodies: incidence, clinical relevance, and pathogenesis  Journal Articles
• Autoimmune heparin‐induced thrombocytopenia  Journal Articles
• B cells, PF4/heparin complexes, and complement  Journal Articles
• Benefit and risk of heparin for maintaining peripheral venous catheters in neonates: a placebo-controlled trial  Journal Articles
• Cellular immune responses to platelet factor 4 and heparin complexes in patients with heparin‐induced thrombocytopenia  Journal Articles
• Characterization of platelet factor 4 amino acids that bind pathogenic antibodies in heparin‐induced thrombocytopenia  Journal Articles
• Chemistry, Measurement, and Clinical Significance of Platelet Specific Proteins  Journal Articles
• Clinical effectiveness of a Bayesian algorithm for the diagnosis and management of heparin‐induced thrombocytopenia  Journal Articles
• Clinical picture of heparin-induced thrombocytopenia (HIT) and its differentiation from non-HIT thrombocytopenia  Journal Articles
• Clinical sample investigation (CSI) hematology: pinpointing the precise onset of heparin‐induced thrombocytopenia (HIT)  Journal Articles
• Close Approximation of Two Platelet Factor 4 Tetramers by Charge Neutralization Forms the Antigens Recognized by HIT Antibodies  Journal Articles
• Combination of 4Ts score and PF4/H-PaGIA for diagnosis and management of heparin-induced thrombocytopenia: prospective cohort study  Journal Articles
• Combination of two complementary automated rapid assays for diagnosis of heparin‐induced thrombocytopenia (HIT)  Journal Articles
• Combined use of the high heparin step and optical density to optimize diagnostic sensitivity and specificity of an anti-PF4/heparin enzyme-immunoassay  Journal Articles
• Confirmatory procedure and other maneuvers to assess pathogenicity of platelet factor 4 (PF4)-dependent antibodies – distinguishing "signal" from "noise"  Journal Articles
• Delayed-Onset Heparin-Induced Thrombocytopenia and Cerebral Thrombosis after a Single Administration of Unfractionated Heparin  Journal Articles
• Delayed-Onset Heparin-Induced Thrombocytopenia and Thrombosis  Journal Articles
• Delayed‐onset HIT caused by low‐molecular‐weight heparin manifesting during fondaparinux prophylaxis  Journal Articles
• Development of a high-yield expression and purification system for platelet factor 4  Journal Articles
• Diagnostic accuracy of IgG‐specific versus polyspecific enzyme‐linked immunoassays in heparin‐induced thrombocytopenia: a systematic review and meta‐analysis  Journal Articles
• Distinguishing between anti–platelet factor 4/heparin antibodies that can and cannot cause heparin‐induced thrombocytopenia  Journal Articles
• Early‐onset and persisting thrombocytopenia in post‐cardiac surgery patients is rarely due to heparin‐induced thrombocytopenia, even when antibody tests are positive  Journal Articles
• Effect of anti‐platelet factor‐4/heparin antibody induction on early saphenous vein graft occlusion after coronary artery bypass surgery  Journal Articles
• Evaluating Diagnostic Algorithms for Heparin-Induced Thrombocytopenia using Two Combined Automated Rapid Immunoassays  Journal Articles
• Evidence for thrombin binding to dermatan sulphate sites in the rabbit aorta subendothelium in vitro  Journal Articles
• FcγRIIa proteolysis as a diagnostic biomarker for heparin-induced thrombocytopenia  Journal Articles
• Fibrinogen proteolysis and platelet alpha-granule release in preeclampsia/eclampsia  Journal Articles
• Fibronectin modulates formation of PF4/heparin complexes and is a potential factor for reducing risk of developing HIT  Journal Articles
• Fondaparinux thromboprophylaxis-associated heparin-induced thrombocytopenia syndrome complicated by arterial thrombotic stroke  Journal Articles
• Fondaparinux: does it cause HIT? can it treat HIT?  Journal Articles
• Formation of anti–platelet factor 4/heparin antibodies after cardiac surgery: Influence of perioperative platelet activation, the inflammatory response, and histocompatibility leukocyte antigen status  Journal Articles
• Frequency of positive anti-PF4/polyanion antibody tests after COVID-19 vaccination with ChAdOx1 nCoV-19 and BNT162b2  Journal Articles
• Genome-wide association study of platelet factor 4/heparin antibodies in heparin-induced thrombocytopenia  Journal Articles
• HITlights: A career perspective on heparin‐induced thrombocytopenia  Journal Articles
• Hemodialysis-Associated Acute Systemic Reactions and Heparin-Induced Thrombocytopenia  Journal Articles
• Heparin or nonheparin anticoagulants for VITT  Journal Articles
• Heparin-Induced Thrombocytopenia  Journal Articles
• Heparin-Induced Thrombocytopenia  Journal Articles
• Heparin-Induced Thrombocytopenia  Journal Articles
• Heparin-Induced Thrombocytopenia in Patients with Ventricular Assist Devices: Are New Prevention Strategies Required?  Journal Articles
• Heparin-Induced Thrombocytopenia: A Ten-Year Retrospective  Journal Articles
• Heparin-induced thrombocytopenia  Journal Articles
• Heparin-induced thrombocytopenia: A stoichiometry-based model to explain the differing immunogenicities of unfractionated heparin, low-molecular-weight heparin, and fondaparinux in different clinical settings  Journal Articles
• Heparin‐induced thrombocytopenia – therapeutic concentrations of danaparoid, unlike fondaparinux and direct thrombin inhibitors, inhibit formation of platelet factor 4–heparin complexes  Journal Articles
• Heparin‐induced thrombocytopenia: a prospective study on the incidence, platelet‐activating capacity and clinical significance of antiplatelet factor 4/heparin antibodies of the IgG, IgM, and IgA classes  Journal Articles
• Heparin‐induced thrombocytopenia: towards standardization of platelet factor 4/heparin antigen tests  Journal Articles
• Heterogeneity of Vaccine-Induced Immune Thrombotic Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination and Safety of Second Vaccination with BNT162b2  Journal Articles
• High sensitivity and specificity of an automated IgG-specific chemiluminescence immunoassay for diagnosis of HIT  Journal Articles
• IV Immunoglobulin for Autoimmune Heparin-Induced Thrombocytopenia  Journal Articles
• Immune heparin-induced thrombocytopenia can occur in patients receiving clopidogrel and aspirin  Journal Articles
• Immunoglobulin G from patients with heparin-induced thrombocytopenia binds to a complex of heparin and platelet factor 4  Journal Articles
• Impact of the patient population on the risk for heparin-induced thrombocytopenia  Journal Articles
• Improving Clinical Interpretation of the Anti-Platelet Factor 4/Heparin Enzyme-Linked Immunosorbent Assay for the Diagnosis of Heparin-Induced Thrombocytopenia Through the Use of Receiver Operating Characteristic Analysis, Stratum-Specific Likelihood Ratios, and Bayes Theorem  Journal Articles
• Incidence and clinical relevance of anti–platelet factor 4/heparin antibodies before cardiac surgery  Journal Articles
• Increased Platelet Destruction  Journal Articles
• Increased heparin clearance in experimental pulmonary embolism.  Journal Articles
• Increased mortality in hemodialysis patients having specific antibodies to the platelet factor 4-heparin complex  Journal Articles
• Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia  Journal Articles
• Investigation of a platelet factor 4 polymorphism on the immune response in patients with heparin-induced thrombocytopenia  Journal Articles
• Laboratory and demographic predictors of functional assay positive status in suspected heparin-induced thrombocytopenia: A multicenter retrospective cohort study  Journal Articles
• Laboratory diagnosis of heparin‐induced thrombocytopenia  Journal Articles
• Laboratory testing for VITT antibodies  Journal Articles
• Laboratory testing for heparin-induced thrombocytopenia.  Journal Articles
• Laboratory testing for heparin‐induced thrombocytopenia: a conceptual framework and implications for diagnosis  Journal Articles
• Lessons from vaccine-induced immune thrombotic thrombocytopenia  Journal Articles
• Limitations of the particle immunofiltration assay test for diagnosis of heparin‐induced thrombocytopenia  Journal Articles
• Management of heparin-induced thrombocytopenia  Journal Articles
• Multicentre evaluation of 5B9, a monoclonal anti‐PF4/heparin IgG mimicking human HIT antibodies, as an internal quality control in HIT functional assays: Communication from the ISTH SSC Subcommittee on Platelet Immunology  Journal Articles
• Neutralization of Heparin Activity  Journal Articles
• New Approaches to the Diagnosis of Heparin-Induced Thrombocytopenia  Journal Articles
• No significant improvement in diagnostic specificity of an anti‐PF4/polyanion immunoassay with use of high heparin confirmatory procedure  Journal Articles
• Nonheparin Anticoagulants for Heparin-Induced Thrombocytopenia  Journal Articles
• Optical Densities Reduce Odds of Heparin-induced Thrombocytopenia Over-diagnosis  Journal Articles
• PF4‐dependent immunoassays and inferential detection of HIT antibodies  Journal Articles
• Performance characteristics of a rapid assay for anti‐PF4/heparin antibodies: the particle immunofiltration assay  Journal Articles
• Performance characteristics of an automated latex immunoturbidimetric assay [HemosIL ® HIT-Ab (PF4-H) ] for the diagnosis of immune heparin-induced thrombocytopenia  Journal Articles
• Plasma exchange to remove HIT antibodies: dissociation between enzyme-immunoassay and platelet activation test reactivities  Journal Articles
• Platelet Activation Testing for Heparin-Induced Thrombocytopenia Antibodies  Journal Articles
• Platelet Factor 4 Interactions with Short Heparin Oligomers: Implications for Folding and Assembly  Journal Articles
• Platelet count recovery and seroreversion in immune HIT despite continuation of heparin: further observations and literature review  Journal Articles
• Platelet factor 4 inhibits ADAMTS13 activity and regulates the multimeric distribution of von Willebrand factor  Journal Articles
• Platelet-Activating Antibodies Are Detectable at the Earliest Onset of Heparin-Induced Thrombocytopenia, With Implications for the Operating Characteristics of the Serotonin-Release Assay  Journal Articles
• Platelet-activating anti-PF4 antibodies mimic VITT antibodies in an unvaccinated patient with monoclonal gammopathy  Journal Articles
• Platelet-activating anti-PF4 disorders: An overview  Journal Articles
• Platelet‐activating immune complexes identified in critically ill COVID‐19 patients suspected of heparin‐induced thrombocytopenia  Journal Articles
• Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis  Journal Articles
• Prevalence and Risk of Preexisting Heparin-Induced Thrombocytopenia Antibodies in Patients With Acute VTE  Journal Articles
• Prevalence and clinical implications of anti-PF4/heparin antibodies in intensive care patients: a prospective observational study  Journal Articles
• Prognostic importance of preoperative anti-PF4/heparin antibodies in patients undergoing cardiac surgery  Journal Articles
• Prospective multicentre cohort study of heparin‐induced thrombocytopenia in acute ischaemic stroke patients  Journal Articles
• Protamine (heparin)‐induced thrombocytopenia: a review of the serological and clinical features associated with anti‐protamine/heparin antibodies  Journal Articles
• Quantitative interpretation of optical density measurements using PF4‐dependent enzyme‐immunoassays  Journal Articles
• Recognition, treatment, and prevention of heparin-induced thrombocytopenia: Review and update  Journal Articles
• Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates  Journal Articles
• Rescue Therapy in Chronic Prothrombotic Autoimmune Anti-PF4 Disorder  Journal Articles
• Risk of heparin-induced thrombocytopenia in patients receiving thromboprophylaxis  Journal Articles
• Serotonin‐release assay‐negative heparin‐induced thrombocytopenia  Journal Articles
• Serotonin‐release assay‐positive but platelet factor 4‐dependent enzyme‐immunoassay negative: HIT or not HIT?  Journal Articles
• Spontaneous HIT syndrome: Knee replacement, infection, and parallels with vaccine-induced immune thrombotic thrombocytopenia  Journal Articles
• Studies of the anti–platelet factor 4/heparin immune response: adapting the enzyme‐linked immunosorbent spot assay for detection of memory B cells against complex antigens  Journal Articles
• Studies of the immune response in heparin-induced thrombocytopenia  Journal Articles
• Studies of α-granule proteins in cultured human megakaryocytes  Journal Articles
• Testing for Heparin-Induced Thrombocytopenia Antibodies  Journal Articles
• Testing for heparin‐induced thrombocytopenia: are we there yet?  Journal Articles
• The COVID Complex: A Review of Platelet Activation and Immune Complexes in COVID-19  Journal Articles
• The Pathophysiology of Heparin-Induced Thrombocytopenia  Journal Articles
• The clinical and laboratory diagnosis of vaccine-induced immune thrombotic thrombocytopenia  Journal Articles
• The effects of high-dose heparin on inflammatory and coagulation parameters following cardiopulmonary bypass  Journal Articles
• The epitope specificity of heparin‐induced thrombocytopenia  Journal Articles
• The impact of Gam-COVID-Vac, an Adv5/Adv26 COVID-19 vaccine, on the biomarkers of endothelial function, coagulation and platelet activation  Journal Articles
• The mechanism of action of thrombin inhibitors.  Journal Articles
• The role of fluid-phase immune complexes in the pathogenesis of heparin-induced thrombocytopenia  Journal Articles
• The serological profile of early-onset and persisting post-cardiac surgery thrombocytopenia complicated by “true” heparin-induced thrombocytopenia  Journal Articles
• The serological profile of fondaparinux-associated heparin-induced thrombocytopenia syndrome  Journal Articles
• The temporal profile of the anti-PF4/heparin immune response  Journal Articles
• The use of well‐characterized sera for the assessment of new diagnostic enzyme‐immunoassays for the diagnosis of heparin‐induced thrombocytopenia  Journal Articles
• Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination  Journal Articles
• Transient pseudothrombocytopenia associated with immune heparin-induced thrombocytopenia complicated by pulmonary embolism  Journal Articles
• Treatment of vaccine-induced immune thrombotic thrombocytopenia (VITT)  Journal Articles
• Venous Thromboembolism and Mild Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination  Journal Articles
• When is HIT Really HIT?  Journal Articles