Journal article
VITT-like Monoclonal Gammopathy of Thrombotic Significance
Abstract
Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is associated with antibodies that target platelet factor 4 (PF4) and are heparin-independent. VITT antibodies are implicated in acute, transient prothrombotic disorders that are triggered by adenoviral vector vaccines against coronavirus disease 2019 or by adenovirus infection. We describe chronic prothrombotic disorders featuring anticoagulant-refractory thromboses and intermittent …
Authors
Wang JJ; Warkentin TE; Schönborn L; Wheeler MB; Geerts WH; Costedoat-Chalumeau N; Gendron N; Ene G; Lozano M; Langer F
Journal
The New England Journal of Medicine, Vol. 392, No. 10, pp. 995–1005
Publisher
Massachusetts Medical Society
Publication Date
March 6, 2025
DOI
10.1056/nejmoa2415930
ISSN
0028-4793
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AdultAgedFemaleHumansMaleMiddle AgedAnticoagulantsAutoantibodiesDrug ResistanceEpitope MappingImmunoglobulins, IntravenousMyeloma ProteinsParaproteinemiasPlatelet CountPlatelet Factor 4Purpura, Thrombocytopenic, IdiopathicRecurrenceThrombosisTyrosine Kinase InhibitorsTreatment OutcomeAdeninePiperidines