Journal article
Incidence and clinical relevance of anti–platelet factor 4/heparin antibodies before cardiac surgery
Abstract
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is caused by anti-platelet factor 4/heparin (PF4/H) immunoglobulin (Ig) G antibodies, which activate platelets. In some patients, anti-PF4/H antibodies are already detectable before cardiac surgery. Whether preoperative presence of antibodies confers adverse prognosis and which particular antibody classes (IgG, IgA, IgM) might be implicated are unknown.
METHODS: We prospectively screened 591 …
Authors
Selleng S; Malowsky B; Itterman T; Bagemühl J; Wessel A; Wollert H-G; Warkentin TE; Greinacher A
Journal
American Heart Journal, Vol. 160, No. 2, pp. 362–369
Publisher
Elsevier
Publication Date
August 2010
DOI
10.1016/j.ahj.2010.05.026
ISSN
0002-8703