Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

Abstract

BACKGROUND: Several cases of unusual thrombotic events and thrombocytopenia have developed after vaccination with the recombinant adenoviral vector encoding the spike protein antigen of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (ChAdOx1 nCov-19, AstraZeneca). More data were needed on the pathogenesis of this unusual clotting disorder. METHODS: We assessed the clinical and laboratory features of 11 patients in Germany and …

Authors

Greinacher A; Thiele T; Warkentin TE; Weisser K; Kyrle PA; Eichinger S

Journal

New England Journal of Medicine, Vol. 384, No. 22, pp. 2092–2101

Publisher

Massachusetts Medical Society

Publication Date

June 3, 2021

DOI

10.1056/nejmoa2104840

ISSN

0028-4793

Associated Experts

Ted Warkentin

Professor Emeritus, Faculty of Health Sciences

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