Journal article
Anti‐PF4/heparin antibody formation postorthopedic surgery thromboprophylaxis: the role of non‐drug risk factors and evidence for a stoichiometry‐based model of immunization
Abstract
BACKGROUND: Heparin-induced thrombocytopenia is an antibody-mediated disorder exhibiting variable frequency in different clinical settings. Antibodies recognize PF4/heparin complexes formed at optimal stoichiometric molar ratios.
OBJECTIVE: To identify clinical factors influencing risk of anti-PF4/heparin immunization.
Authors
WARKENTIN TE; COOK RJ; MARDER VJ; GREINACHER A
Journal
Journal of Thrombosis and Haemostasis, Vol. 8, No. 3, pp. 504–512
Publisher
Elsevier
Publication Date
3 2010
DOI
10.1111/j.1538-7836.2009.03735.x
ISSN
1538-7933