Journal article
Platelet factor 4 inhibits ADAMTS13 activity and regulates the multimeric distribution of von Willebrand factor
Abstract
The efficiency of von Willebrand factor (VWF) in thrombus formation is related to its multimeric size, which is controlled by the protease ADAMTS13. However, it is not clear what regulates ADAMTS13 activity. In this study, we investigated whether PF4 could bind to VWF and inhibit ADAMTS13 activity. We found that PF4 binds to VWF and protects against ADAMTS13 activity. We also found that VWF-PF4 complexes circulate in patients with thrombotic …
Authors
Nazy I; Elliott TD; Arnold DM
Journal
British Journal of Haematology, Vol. 190, No. 4, pp. 594–598
Publisher
Wiley
Publication Date
August 2020
DOI
10.1111/bjh.16553
ISSN
0007-1048