Journal article
A comparative study of platelet factor 4‐enhanced platelet activation assays for the diagnosis of heparin‐induced thrombocytopenia
Abstract
BACKGROUND: Functional platelet activation assays, such as the serotonin release assay (SRA), are the gold standard for the diagnosis of heparin-induced thrombocytopenia (HIT). Recently, platelet activation assays using added platelet factor 4 (PF4) have been described and suggest improved sensitivity. Direct comparisons of these assays have not been performed.
OBJECTIVE: We compare the performance characteristics of three PF4-enhanced platelet …
Authors
Rubino JG; Arnold DM; Warkentin TE; Smith JW; Kelton JG; Nazy I
Journal
Journal of Thrombosis and Haemostasis, Vol. 19, No. 4, pp. 1096–1102
Publisher
Elsevier
Publication Date
April 2021
DOI
10.1111/jth.15233
ISSN
1538-7933