Molecular Chaperones Concept

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• 4‐Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe ^−/− mice  Academic Article
• A Method for Expression and Purification of Soluble, Active Hsp47, a Collagen-Specific Molecular Chaperone  Academic Article
• A biophysical toolset to probe the microscopic processes underlying protein aggregation and its inhibition by molecular chaperones  Academic Article
• A phase I dose-escalation study of apatorsen (OGX-427), an antisense inhibitor targeting heat shock protein 27 (Hsp27), in patients with castration-resistant prostate cancer and other advanced cancers  Conference Paper
• Activation of the Unfolded Protein Response Occurs at All Stages of Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice  Academic Article
• Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP  Academic Article
• Addressing taxane resistance in metastatic castration-resistant prostate cancer: a focus on chaperone proteins  Academic Article
• Alterations in Mitochondrial and Apoptosis-regulating Gene Expression in Photodynamic Therapy-resistant Variants of HT29 Colon Carcinoma Cells¶  Academic Article
• Apatorsen plus docetaxel versus docetaxel alone in platinum-resistant metastatic urothelial carcinoma (Borealis-2)  Academic Article
• Association of Multiple Cellular Stress Pathways With Accelerated Atherosclerosis in Hyperhomocysteinemic Apolipoprotein E-Deficient Mice  Academic Article
• Bardet-Biedl Syndrome Gene Variants Are Associated With Both Childhood and Adult Common Obesity in French Caucasians  Academic Article
• CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control  Academic Article
• COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux  Academic Article
• Can social support during pregnancy affect maternal DNA methylation? Findings from a cohort of African-Americans  Academic Article
• Characterization of the stress-inducing effects of homocysteine  Academic Article
• Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting  Academic Article
• Chlamydia Outer Protein (Cop) B from Chlamydia pneumoniae possesses characteristic features of a type III secretion (T3S) translocator protein  Academic Article
• Cigarette Smoke Exposure Leads to Follicle Loss via an Alternative Ovarian Cell Death Pathway in a Mouse Model  Academic Article
• Cooperative Interactions between Androgen Receptor (AR) and Heat-Shock Protein 27 Facilitate AR Transcriptional Activity  Academic Article
• Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA  Academic Article
• Effect of Age on the Processing and Import of Matrix-Destined Mitochondrial Proteins in Skeletal Muscle  Academic Article
• Effect of FKBP65, a putative elastin chaperone, on the coacervation of tropoelastin in vitro  Academic Article
• Endoplasmic Reticulum Chaperone Protein GRP78 Protects Cells from Apoptosis Induced by Topoisomerase Inhibitors  Academic Article
• Functional relatedness in the Inv/Mxi-Spa type III secretion system family  Academic Article
• Gene expression profiling in human skeletal muscle during recovery from eccentric exercise  Academic Article
• Genetically distinct pathways guide effector export through the type VI secretion system  Academic Article
• Getting a GRP on Tissue Factor Activation  Academic Article
• Glucosamine-Induced Endoplasmic Reticulum Stress Promotes ApoB100 Degradation  Academic Article
• Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-κB signaling  Academic Article
• High-Throughput Screening for Human Lysosomal β-N-Acetyl Hexosaminidase Inhibitors Acting as Pharmacological Chaperones  Academic Article
• Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways  Academic Article
• Identification of Small Molecule Chemical Inhibitors of the Collagen-Specific Chaperone Hsp47  Academic Article
• Identification of a hTid-1 mutation which sensitizes gliomas to apoptosis  Academic Article
• Identification of the Docking Site between a Type III Secretion System ATPase and a Chaperone for Effector Cargo  Academic Article
• Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells  Academic Article
• Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition  Academic Article
• Inhibitor screening of pharmacological chaperones for lysosomal β-glucocerebrosidase by capillary electrophoresis  Academic Article
• Low Density Lipoprotein Receptor-Related Protein-2 Expression in Efferent Duct and Epididymal Epithelia: Evidence in Rats for its in Vivo Role in Endocytosis of Apolipoprotein J/Clusterin1  Academic Article
• Mapping Hsp47 binding site(s) using CNBr peptides derived from type I and type II collagen  Academic Article
• Mechanism of loading and translocation of type VI secretion system effector Tse6  Academic Article
• Mitochondrial Proteins at Unexpected Cellular Locations: Export of Proteins from Mitochondria from an Evolutionary Perspective  Academic Article
• Molecular Mechanism for the Suppression of Alpha Synuclein Membrane Toxicity by an Unconventional Extracellular Chaperone  Academic Article
• Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli  Academic Article
• N-acetyllactosamine-induced retraction of bundle-forming pili regulates virulence-associated gene expression in enteropathogenic Escherichia coli  Academic Article
• Novel SCO2 mutation (G1521A) presenting as a spinal muscular atrophy type I phenotype  Academic Article
• Overexpression of the 78-kDa Glucose-regulated Protein/Immunoglobulin-binding Protein (GRP78/BiP) Inhibits Tissue Factor Procoagulant Activity  Academic Article
• Pediatric patients with pheochromocytoma and paraganglioma should have routine preoperative genetic testing for common susceptibility genes in addition to imaging to detect extra-adrenal and metastatic tumors  Conference Paper
• Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death  Academic Article
• Photodynamic Therapy Resistant Human Colon Carcinoma HT29 Cells Show Cross-Resistance to UVA but not UVC Light  Academic Article
• Role of Endoplasmic Reticulum Calcium Disequilibria in the Mechanism of Homocysteine-Induced ER Stress  Academic Article
• SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells  Academic Article
• Stationary Phase Expression of a Novel Escherichia coli Outer Membrane Lipoprotein and Its Relationship with Mammalian Apolipoprotein D  Academic Article
• Structural and Biochemical Characterization of SrcA, a Multi-Cargo Type III Secretion Chaperone in Salmonella Required for Pathogenic Association with a Host  Academic Article
• Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones  Academic Article
• Sulfated glycoprotein-2 synthesized by nonciliated cells of the efferent ducts is targeted to the lysosomal compartment  Academic Article
• Targeting of endogenous sulfated glycoprotein-1 and -2 to lysosomes within nonciliated cells of the efferent ducts during postnatal development of the rat  Academic Article
• The Gene Sr33, an Ortholog of Barley Mla Genes, Encodes Resistance to Wheat Stem Rust Race Ug99  Academic Article
• The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA  Academic Article
• Unusual Cellular Disposition of the Mitochondrial Molecular Chaperones Hsp60, Hsp70 and Hsp10  Academic Article
• Up-regulation of Hsp27 Plays a Role in the Resistance of Human Colon Carcinoma HT29 Cells to Photooxidative Stress¶  Academic Article