Molecular Chaperones Concept

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• 4‐Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe ^−/− mice  Journal Articles
• N‐acetyllactosamine‐induced retraction of bundle‐forming pili regulates virulence‐associated gene expression in enteropathogenic Escherichia coli  Journal Articles
• A Method for Expression and Purification of Soluble, Active Hsp47, a Collagen-Specific Molecular Chaperone  Journal Articles
• A biophysical toolset to probe the microscopic processes underlying protein aggregation and its inhibition by molecular chaperones  Journal Articles
• A phase I dose-escalation study of apatorsen (OGX-427), an antisense inhibitor targeting heat shock protein 27 (Hsp27), in patients with castration-resistant prostate cancer and other advanced cancers  Conferences
• Activation of the Unfolded Protein Response Occurs at All Stages of Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice  Journal Articles
• Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP  Journal Articles
• Addressing Taxane Resistance in Metastatic Castration-Resistant Prostate Cancer: A Focus On Chaperone Proteins  Journal Articles
• Alterations in Mitochondrial and Apoptosis‐regulating Gene Expression in Photodynamic Therapy‐resistant Variants of HT29 Colon Carcinoma Cells^¶  Journal Articles
• Apatorsen plus docetaxel versus docetaxel alone in platinum-resistant metastatic urothelial carcinoma (Borealis-2)  Journal Articles
• Association of Multiple Cellular Stress Pathways With Accelerated Atherosclerosis in Hyperhomocysteinemic Apolipoprotein E-Deficient Mice  Journal Articles
• CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control  Journal Articles
• COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux  Journal Articles
• Can social support during pregnancy affect maternal DNA methylation? Findings from a cohort of African-Americans  Journal Articles
• Characterization of the stress-inducing effects of homocysteine  Journal Articles
• Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting  Journal Articles
• Chlamydia Outer Protein (Cop) B from Chlamydia pneumoniae possesses characteristic features of a type III secretion (T3S) translocator protein  Journal Articles
• Cigarette Smoke Exposure Leads to Follicle Loss via an Alternative Ovarian Cell Death Pathway in a Mouse Model  Journal Articles
• Cooperative Interactions between Androgen Receptor (AR) and Heat-Shock Protein 27 Facilitate AR Transcriptional Activity  Journal Articles
• Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA  Journal Articles
• Effect of Age on the Processing and Import of Matrix-Destined Mitochondrial Proteins in Skeletal Muscle  Journal Articles
• Effect of FKBP65, a putative elastin chaperone, on the coacervation of tropoelastin in vitro  Journal Articles
• Endoplasmic Reticulum Chaperone Protein GRP78 Protects Cells from Apoptosis Induced by Topoisomerase Inhibitors  Journal Articles
• Functional relatedness in the Inv/Mxi‐Spa type III secretion system family  Journal Articles
• Gene expression profiling in human skeletal muscle during recovery from eccentric exercise  Journal Articles
• Genetically distinct pathways guide effector export through the type VI secretion system  Journal Articles
• Getting a GRP on Tissue Factor Activation  Journal Articles
• Glucosamine-Induced Endoplasmic Reticulum Stress Promotes ApoB100 Degradation  Journal Articles
• Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-κB signaling  Journal Articles
• High-Throughput Screening for Human Lysosomal β-N-Acetyl Hexosaminidase Inhibitors Acting as Pharmacological Chaperones  Journal Articles
• Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways  Journal Articles
• Identification of Small Molecule Chemical Inhibitors of the Collagen-Specific Chaperone Hsp47  Journal Articles
• Identification of a hTid‐1 mutation which sensitizes gliomas to apoptosis  Journal Articles
• Identification of the Docking Site between a Type III Secretion System ATPase and a Chaperone for Effector Cargo  Journal Articles
• Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells  Journal Articles
• Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition  Journal Articles
• Inhibitor screening of pharmacological chaperones for lysosomal β-glucocerebrosidase by capillary electrophoresis  Journal Articles
• Low Density Lipoprotein Receptor-Related Protein-2 Expression in Efferent Duct and Epididymal Epithelia: Evidence in Rats for its in Vivo Role in Endocytosis of Apolipoprotein J/Clusterin1  Journal Articles
• Mapping Hsp47 binding site(s) using CNBr peptides derived from type I and type II collagen  Journal Articles
• Mechanism of loading and translocation of type VI secretion system effector Tse6  Journal Articles
• Mitochondrial Proteins at Unexpected Cellular Locations: Export of Proteins from Mitochondria from an Evolutionary Perspective  Journal Articles
• Molecular Mechanism for the Suppression of Alpha Synuclein Membrane Toxicity by an Unconventional Extracellular Chaperone  Journal Articles
• Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli  Journal Articles
• Novel SCO2 mutation (G1521A) presenting as a spinal muscular atrophy type I phenotype  Journal Articles
• Overexpression of the 78-kDa Glucose-regulated Protein/Immunoglobulin-binding Protein (GRP78/BiP) Inhibits Tissue Factor Procoagulant Activity  Journal Articles
• Pediatric patients with pheochromocytoma and paraganglioma should have routine preoperative genetic testing for common susceptibility genes in addition to imaging to detect extra-adrenal and metastatic tumors  Conferences
• Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death  Journal Articles
• Photodynamic Therapy Resistant Human Colon Carcinoma HT29 Cells Show Cross‐Resistance to UVA but not UVC Light  Journal Articles
• Quantitative Genome-Wide Genetic Interaction Screens Reveal Global Epistatic Relationships of Protein Complexes in Escherichia coli  Journal Articles
• Role of Endoplasmic Reticulum Calcium Disequilibria in the Mechanism of Homocysteine-Induced ER Stress  Journal Articles
• Severe Burn-Induced Endoplasmic Reticulum Stress and Hepatic Damage in Mice  Journal Articles
• SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells  Journal Articles
• Stationary Phase Expression of a Novel Escherichia coli Outer Membrane Lipoprotein and Its Relationship with Mammalian Apolipoprotein D  Journal Articles
• Structural and Biochemical Characterization of SrcA, a Multi-Cargo Type III Secretion Chaperone in Salmonella Required for Pathogenic Association with a Host  Journal Articles
• Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones  Journal Articles
• Sulfated glycoprotein‐2 synthesized by nonciliated cells of the efferent ducts is targeted to the lysosomal compartment  Journal Articles
• Targeting of endogenous sulfated glycoprotein‐1 and ‐2 to lysosomes within nonciliated cells of the efferent ducts during postnatal development of the rat  Journal Articles
• The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA  Journal Articles
• The clinical and genetic spectrum of autosomal-recessive TOR1A-related disorders  Journal Articles
• Transcriptome Profiling and Functional Analysis ofAgrobacterium tumefaciensReveals a General Conserved Response to Acidic Conditions (pH 5.5) and a Complex Acid-Mediated Signaling Involved inAgrobacterium-Plant Interactions  Journal Articles
• Unusual Cellular Disposition of the Mitochondrial Molecular Chaperones Hsp60, Hsp70 and Hsp10  Journal Articles
• Up-regulation of Hsp27 Plays a Role in the Resistance of Human Colon Carcinoma HT29 Cells to Photooxidative Stress¶  Journal Articles