Journal article
Cooperative Interactions between Androgen Receptor (AR) and Heat-Shock Protein 27 Facilitate AR Transcriptional Activity
Abstract
Androgen receptor (AR) transactivation is known to enhance prostate cancer cell survival. However, the precise effectors by which the prosurvival effects of androgen and AR drive prostate cancer progression are poorly defined. Here, we identify a novel feed-forward loop involving cooperative interactions between ligand-activated AR and heat-shock protein 27 (Hsp27) phospho-activation that enhance AR stability, shuttling, and transcriptional …
Authors
Zoubeidi A; Zardan A; Beraldi E; Fazli L; Sowery R; Rennie P; Nelson C; Gleave M
Journal
Cancer Research, Vol. 67, No. 21, pp. 10455–10465
Publisher
American Association for Cancer Research (AACR)
Publication Date
November 1, 2007
DOI
10.1158/0008-5472.can-07-2057
ISSN
0008-5472
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsApoptosisCell Line, TumorHSP27 Heat-Shock ProteinsHeat-Shock ProteinsHumansMaleMiceMice, NudeMolecular ChaperonesNeoplasm ProteinsPhosphorylationProstate-Specific AntigenProstatic NeoplasmsProteasome Endopeptidase ComplexReceptors, AndrogenResponse ElementsTranscription, GeneticUbiquitinationp38 Mitogen-Activated Protein Kinases