Methotrexate Concept

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• 2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis  Journal Articles
• Genetic knockdown of a single organic anion transporter alters the expression of functionally related genes in Malpighian tubules ofDrosophila melanogaster  Journal Articles
• HER2and Responsiveness of Breast Cancer to Adjuvant Chemotherapy  Journal Articles
• Parent‐Reported Medication Side Effects and Their Impact on Health‐Related Quality of Life in Children With Juvenile Idiopathic Arthritis  Conferences
• A 2.13 Å Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region  Journal Articles
• A novel methotrexate protocol for the resolution of tubal ectopic pregnancies; Methodological issues on prognostic studies: Response  Journal Articles
• A patient with primary sclerosing cholangitis ponders pulse: Methotrexate paper  Journal Articles
• A randomized trial comparing 12 weeks versus 36 weeks of adjuvant chemotherapy in stage II breast cancer.  Journal Articles
• Addition of anti-thymocyte globulin to standard graft-versus-host disease prophylaxis versus standard treatment alone in patients with haematological malignancies undergoing transplantation from unrelated donors: final analysis of a randomised, open-label, multicentre, phase 3 trial  Journal Articles
• Adjuvant Chemotherapy for Breast Cancer — 30 Years Later  Journal Articles
• Adjuvant chemotherapy with CEF versus CMF for node-positive breast cancer.  Journal Articles
• Adverse Drug Reactions in Canada in 2009–2018: Insights from the Canada Vigilance Database  Journal Articles
• Analysis of dose intensity for adjuvant chemotherapy trials in stage II breast cancer.  Journal Articles
• Analysis of dose intensity for chemotherapy in early (stage II) and advanced breast cancer.  Journal Articles
• Assessment of the cardioprotective effect of liraglutide on methotrexate induced cardiac dysfunction through suppression of inflammation and enhancement of angiogenesis in rats.  Journal Articles
• Associations Between Methotrexate Use and the Risk of Cardiovascular Events in Patients with Elderly-onset Rheumatoid Arthritis  Journal Articles
• Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Luminal Crohn’s Disease  Journal Articles
• Case 216: Hypertrophic Spinal Pachymeningitis  Journal Articles
• Cervical Ectopic Pregnancy Complicated by Escherichia Coli Septicemia: A Case Report  Journal Articles
• Chemotherapy for metastatic transitional carcinoma of the urinary tract:A prospective trial of methotrexate, adriamycin, and cyclophosphamide (MAC) with cis-platinum for failure  Journal Articles
• Combination Therapy With Methotrexate in Inflammatory Bowel Disease: Time to COMMIT?  Journal Articles
• Combination chemotherapy using high or low dose methotrexate for small cell carcinoma of the lung — A randomised trial  Journal Articles
• Combined Modality Treatment of Small Cell Carcinoma of the Lung  Journal Articles
• Combined methotrexate–dactinomycin: An effective therapy for low-risk gestational trophoblastic neoplasia  Journal Articles
• Comparing Canadian paediatric rheumatology practice to the 2019 ACR Juvenile Idiopathic Arthritis guidelines: results from the CAPRI Registry  Journal Articles
• Cost-effectiveness analysis of rituximab with methotrexate, cytarabine and thiotepa for the treatment of patients with primary central nervous system lymphoma  Journal Articles
• Current quality-of-life research challenges in arthritis relevant to the issue of clinical significance  Journal Articles
• Ectopic Pregnancy in a Caesarean Scar: A Case Report  Journal Articles
• Editorial: methotrexate in patients with Crohn's disease refractory to anti‐TNF therapy—moving backwards yet forward?  Journal Articles
• Effect of Concomitant Disease-modifying Antirheumatic Drugs and Methotrexate Administration Route on Biologic Treatment Durability in Rheumatoid Arthritis: OBRI Cohort Results  Journal Articles
• Effectiveness of antibacterial prophylaxis during induction chemotherapy in children with acute lymphoblastic leukemia  Journal Articles
• Effects of a treatment gap during adjuvant chemotherapy in node-positive breast cancer: results of International Breast Cancer Study Group (IBCSG) Trials 13-93 and 14-93  Journal Articles
• Effects of acute or chronic exposure to dietary organic anions on secretion of methotrexate and salicylate by Malpighian tubules ofDrosophila melanogasterlarvae  Journal Articles
• Efficacy of Immunosuppressive Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis  Journal Articles
• Efficacy of certolizumab pegol across baseline rheumatoid factor subgroups in patients with rheumatoid arthritis: Post‐hoc analysis of clinical trials  Journal Articles
• First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis  Journal Articles
• Fluoride therapy in prevention of rheumatoid arthritis induced bone loss.  Journal Articles
• Hepatotoxicity Caused by Methotrexate Therapy in Children with Inflammatory Bowel Disease  Journal Articles
• Heterogeneity in Patient Characteristics and Differences in Treatment Across 4 Canadian Rheumatoid Arthritis Cohorts  Journal Articles
• High Incidence of Vertebral Fractures in Children With Acute Lymphoblastic Leukemia 12 Months After the Initiation of Therapy  Journal Articles
• High-Dose Methotrexate for Gestational Trophoblastic Disease  Journal Articles
• Improvement in health utility among patients with rheumatoid arthritis treated with adalimumab (a human anti-TNF monoclonal antibody) plus methotrexate  Journal Articles
• Incidence and Prognostic Impact of Amenorrhea During Adjuvant Therapy in High-Risk Premenopausal Breast Cancer: Analysis of a National Cancer Institute of Canada Clinical Trials Group Study—NCIC CTG MA.5  Journal Articles
• Influence of One Human Leukocyte Antigen Mismatch on Outcome of Allogeneic Bone Marrow Transplantation from Related Donors  Journal Articles
• Interactions between detoxification mechanisms and excretion in Malpighian tubules ofDrosophila melanogaster  Journal Articles
• Interventions for cutaneous disease in systemic lupus erythematosus  Journal Articles
• Intramuscular Methotrexate-Induced Aseptic Meningitis  Journal Articles
• Limited GPA and Alpha-1 Antitrypsin Deficiency in a Pediatric Patient  Journal Articles
• Long-term outcome of a pediatric-inspired regimen used for adults aged 18–50 years with newly diagnosed acute lymphoblastic leukemia  Journal Articles
• Low-Dose Methotrexate and Serious Adverse Events Among Older Adults With Chronic Kidney Disease  Journal Articles
• Management of Children with Acute Lymphoblastic Leukemia by the Dana-Farber Cancer Institute Protocols  Journal Articles
• Management of Ontario children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols.  Journal Articles
• Medical Management of a Cervical Pregnancy: A Case Report  Journal Articles
• Methotrexate and Lung Disease in Rheumatoid Arthritis: A Meta‐Analysis of Randomized Controlled Trials  Journal Articles
• Methotrexate in rheumatoid arthritis. Impact on quality of life assessed by traditional standard-item and individualized patient preference health status questionnaires  Journal Articles
• Methotrexate reduced pain and improved function in symptomatic knee osteoarthritis  Journal Articles
• Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials  Journal Articles
• Methotrexate/fluorouracil scheduling influences normal tissue toxicity but not antitumor effects in patients with squamous cell head and neck cancer: results from a randomized trial.  Journal Articles
• Methyl-CCNU and Methotrexate Therapy in Patients with Advanced Colorectal Cancer After Failure of 5-Fluorouracil Chemotherapy  Journal Articles
• Modulation of 5-FU metabolism in human MCF-7 breast carcinoma cells.  Journal Articles
• Modulation of the antitumor effect of methotrexate by low-dose leucovorin in squamous cell head and neck cancer: a randomized placebo-controlled clinical trial.  Journal Articles
• Neuropsychological Outcomes From a Randomized Trial of Triple Intrathecal Chemotherapy Compared With 18 Gy Cranial Radiation As CNS Treatment in Acute Lymphoblastic Leukemia: Findings From Dana-Farber Cancer Institute ALL Consortium Protocol 95-01  Journal Articles
• New Applications for Traditional Drugs in Inflammatory Bowel Disease  Journal Articles
• Optimal pathological response after neoadjuvant chemotherapy for muscle‐invasive bladder cancer: results from a global, multicentre collaboration  Journal Articles
• Phase‐specific risks of outpatient visits, emergency visits, and hospitalizations during Children's Oncology Group‐based treatment for childhood acute lymphoblastic leukemia: A population‐based study  Journal Articles
• Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster  Journal Articles
• Potential effects of a national consensus statement on optimal treatment of early rheumatoid arthritis in Ontario  Journal Articles
• Prevalence and significance of large granular lymphocytes in patients with immune thrombocytopenia  Journal Articles
• Primary brain T-cell lymphoma of the lymphoblastic type presenting as altered mental status  Journal Articles
• Prognostic accuracy of a novel methotrexate protocol for the resolution of tubal ectopic pregnancies  Journal Articles
• Prospective randomized trial of one-hour sequential versus simultaneous methotrexate plus 5-fluorouracil in advanced and recurrent squamous cell head and neck cancer.  Journal Articles
• Psoriasis in systemic lupus erythematosus: a single-center experience  Journal Articles
• Purification and properties of dihydrofolate reductase from cultured mammalian cells  Journal Articles
• Purification and properties of dihydrofolate reductase from methotrexate-sensitive and methotrexate-resistant Chinese hamster ovary cells  Journal Articles
• Purification of tetrahydrofolate dehydrogenase by affinity chromatography  Journal Articles
• Randomized Trial Comparing Cyclophosphamide, Epirubicin, and Fluorouracil With Cyclophosphamide, Methotrexate, and Fluorouracil in Premenopausal Women With Node-Positive Breast Cancer: Update of National Cancer Institute of Canada Clinical Trials Group Trial MA5  Journal Articles
• Randomized trial of cyclophosphamide, methotrexate, and fluorouracil chemotherapy added to tamoxifen as adjuvant therapy in postmenopausal women with node-positive estrogen and/or progesterone receptor-positive breast cancer: a report of the National Cancer Institute of Canada Clinical Trials Group. Breast Cancer Site Group.  Journal Articles
• Randomized trial of intensive cyclophosphamide, epirubicin, and fluorouracil chemotherapy compared with cyclophosphamide, methotrexate, and fluorouracil in premenopausal women with node-positive breast cancer. National Cancer Institute of Canada Clinical Trials Group.  Journal Articles
• Real‐World Effectiveness of Common Treatment Strategies for Juvenile Idiopathic Arthritis: Results From a Canadian Cohort  Journal Articles
• Reply  Journal Articles
• Reply to: methotrexate and not much harm to the lungs by H. Yazici.  Journal Articles
• Response times follow lognormal or gamma distribution in arthritis patients  Journal Articles
• Responsiveness of Intrinsic Subtypes to Adjuvant Anthracycline Substitution in the NCIC.CTG MA.5 Randomized Trial  Journal Articles
• Retention of triple therapy with methotrexate, sulfasalazine, and hydroxychloroquine compared to combination methotrexate and leflunomide in rheumatoid arthritis  Journal Articles
• Risk Factors and Clinical Outcomes Associated With Sarcopenia in Rheumatoid Arthritis  Journal Articles
• Risk of Acute Leukemia Following Epirubicin-Based Adjuvant Chemotherapy: A Report From the National Cancer Institute of Canada Clinical Trials Group  Journal Articles
• Risk of liver injury among methotrexate users: A meta-analysis of randomised controlled trials  Journal Articles
• STABILIZATION OF DIHYDROFOLATE REDUCTASE BY INHIBITORS IN VIVO AND IN VITRO*  Journal Articles
• Selective assay for herpes simplex viruses expressing thymidine kinase  Journal Articles
• Skeletal Morbidity in Childhood Acute Lymphoblastic Leukemia  Journal Articles
• Successful medical treatment of a hepatic pregnancy: a case report  Journal Articles
• Survival results from a phase III study of simultaneous versus 1‐hour sequential methotrexate—5‐fluorouracil chemotherapy in head and neck cancer  Journal Articles
• Systemic Immunomodulatory Treatments for Patients With Atopic Dermatitis  Journal Articles
• The Longterm Effect of Early Intensive Treatment of Seniors with Rheumatoid Arthritis: A Comparison of 2 Population-based Cohort Studies on Time to Joint Replacement Surgery  Journal Articles
• The Thrombogenic Effect of Anticancer Drug Therapy in Women with Stage II Breast Cancer  Journal Articles
• The case of methotrexate and the lung: Dr Jekyll and Mr Hyde  Journal Articles
• The chemotherapy of granulosa cell tumors of the ovary: Experience of the wisconsin clinical cancer center  Journal Articles
• The effect of systemic adjuvant chemotherapy on local breast recurrence in node positive breast cancer patients treated by lumpectomy without radiation  Journal Articles
• The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces  Journal Articles
• Timing of CMF chemotherapy in combination with tamoxifen in postmenopausal women with breast cancer: role of endocrine responsiveness of the tumor  Journal Articles
• Tofacitinib in Combination With Methotrexate in Patients With Rheumatoid Arthritis: Clinical Efficacy, Radiographic, and Safety Outcomes From a Twenty‐Four–Month, Phase III Study  Journal Articles
• Tolerance of Radiotherapy and Chemotherapy in Elderly Patients With Bladder Cancer  Journal Articles
• Topoisomerase II alpha protein and responsiveness of breast cancer to adjuvant chemotherapy with CEF compared to CMF in the NCIC CTG randomized MA.5 adjuvant trial  Journal Articles
• Treatment Strategies in Early Rheumatoid Arthritis Methotrexate Management: Results From a Prospective Cohort  Journal Articles
• Treatment and its side effects in ANCA-associated vasculitides – Study based on POLVAS registry data  Journal Articles
• Treatment of central nervous system tumors with methotrexate.  Journal Articles
• Upadacitinib in patients with psoriatic arthritis and an inadequate response to non-biological therapy: 56-week data from the phase 3 SELECT-PsA 1 study  Journal Articles
• Weekly Intravenous Methotrexate with Folinic Acid for Nonmetastatic Gestational Trophoblastic Neoplasia  Journal Articles
• What drives the comparative effectiveness of biologics vs methotrexate in rheumatoid arthritis? Meta-regression and graphical inspection of suspected clinical factors  Journal Articles