Methotrexate Concept

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• Genetic knockdown of a single organic anion transporter alters the expression of functionally related genes in Malpighian tubules ofDrosophila melanogaster  Academic Article
• HER2and Responsiveness of Breast Cancer to Adjuvant Chemotherapy  Academic Article
• A 2.13 Å Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region  Academic Article
• A novel methotrexate protocol for the resolution of tubal ectopic pregnancies; Methodological issues on prognostic studies: Response  Academic Article
• A patient with primary sclerosing cholangitis ponders pulse: Methotrexate paper  Academic Article
• A randomized trial comparing 12 weeks versus 36 weeks of adjuvant chemotherapy in stage II breast cancer.  Academic Article
• Addition of anti-thymocyte globulin to standard graft-versus-host disease prophylaxis versus standard treatment alone in patients with haematological malignancies undergoing transplantation from unrelated donors: final analysis of a randomised, open-label, multicentre, phase 3 trial  Academic Article
• Adjuvant Chemotherapy for Breast Cancer — 30 Years Later  Academic Article
• Adjuvant Therapy for Premenopausal Women With Breast Cancer: Is It Time for Another Paradigm Shift?  Academic Article
• Adjuvant chemotherapy with CEF versus CMF for node-positive breast cancer.  Academic Article
• Adverse Drug Reactions in Canada in 2009–2018: Insights from the Canada Vigilance Database  Academic Article
• Analysis of dose intensity for adjuvant chemotherapy trials in stage II breast cancer.  Academic Article
• Analysis of dose intensity for chemotherapy in early (stage II) and advanced breast cancer.  Academic Article
• Assessment of the cardioprotective effect of liraglutide on methotrexate induced cardiac dysfunction through suppression of inflammation and enhancement of angiogenesis in rats.  Academic Article
• Associations Between Methotrexate Use and the Risk of Cardiovascular Events in Patients with Elderly-onset Rheumatoid Arthritis  Academic Article
• Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Luminal Crohn’s Disease  Academic Article
• Case 216: Hypertrophic Spinal Pachymeningitis  Academic Article
• Cervical Ectopic Pregnancy Complicated by Escherichia Coli Septicemia: A Case Report  Academic Article
• Clinical application of the concept of methotrexate plus 5-FU sequence-dependent "synergy": how good is the evidence?  Academic Article
• Clinical pharmacology of gold  Academic Article
• Clinical responsiveness of self-report functional assessment measures for children with juvenile idiopathic arthritis undergoing intraarticular corticosteroid injections  Academic Article
• Combination Therapy With Methotrexate in Inflammatory Bowel Disease: Time to COMMIT?  Academic Article
• Combination antifol therapy: observations on the development of resistant L1210 leukemic cells in vivo.  Academic Article
• Combination therapy of cyclosporine with methotrexate and gold in rheumatoid arthritis (2 pilot studies).  Academic Article
• Combined methotrexate–dactinomycin: An effective therapy for low-risk gestational trophoblastic neoplasia  Academic Article
• Comparison of leucovorin protection from variety of antifolates in human lymphoid cell lines  Academic Article
• Comparison of thymidine and folinic acid protection from methotrexate toxicity in human lymphoid cell lines.  Academic Article
• Current quality-of-life research challenges in arthritis relevant to the issue of clinical significance  Academic Article
• Differential calcium leucovorin protection of human lymphoid cell lines from methotrexate  Academic Article
• Ectopic Pregnancy in a Caesarean Scar: A Case Report  Academic Article
• Editorial: methotrexate in patients with Crohn's disease refractory to anti-TNF therapy-moving backwards yet forward?  Academic Article
• Effect of Concomitant Disease-modifying Antirheumatic Drugs and Methotrexate Administration Route on Biologic Treatment Durability in Rheumatoid Arthritis: OBRI Cohort Results  Academic Article
• Effectiveness of antibacterial prophylaxis during induction chemotherapy in children with acute lymphoblastic leukemia  Academic Article
• Effects of a treatment gap during adjuvant chemotherapy in node-positive breast cancer: results of International Breast Cancer Study Group (IBCSG) Trials 13-93 and 14-93  Academic Article
• Effects of acute or chronic exposure to dietary organic anions on secretion of methotrexate and salicylate by Malpighian tubules ofDrosophila melanogasterlarvae  Academic Article
• Efficacy of Immunosuppressive Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis  Academic Article
• First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis  Academic Article
• Fluoride therapy in prevention of rheumatoid arthritis induced bone loss.  Academic Article
• Graft-versus-host disease following marrow transplantation for aplastic anemia: different impact of two GVHD prevention strategies  Academic Article
• Hepatotoxicity Caused by Methotrexate Therapy in Children with Inflammatory Bowel Disease  Academic Article
• Heterogeneity in Patient Characteristics and Differences in Treatment Across 4 Canadian Rheumatoid Arthritis Cohorts  Academic Article
• High Incidence of Vertebral Fractures in Children With Acute Lymphoblastic Leukemia 12 Months After the Initiation of Therapy  Academic Article
• High-Dose Methotrexate for Gestational Trophoblastic Disease  Academic Article
• Incidence and Prognostic Impact of Amenorrhea During Adjuvant Therapy in High-Risk Premenopausal Breast Cancer: Analysis of a National Cancer Institute of Canada Clinical Trials Group Study—NCIC CTG MA.5  Academic Article
• Increased thromboembolic complications with concurrent tamoxifen and chemotherapy in a randomized trial of adjuvant therapy for women with breast cancer. National Cancer Institute of Canada Clinical Trials Group Breast Cancer Site Group.  Academic Article
• Influence of One Human Leukocyte Antigen Mismatch on Outcome of Allogeneic Bone Marrow Transplantation from Related Donors  Academic Article
• Interactions between detoxification mechanisms and excretion in Malpighian tubules ofDrosophila melanogaster  Academic Article
• Interventions for cutaneous disease in systemic lupus erythematosus  Academic Article
• Intramuscular Methotrexate-Induced Aseptic Meningitis  Academic Article
• Late effects of high-dose methotrexate treatment in childhood cancer survivors—a systematic review  Academic Article
• Limited GPA and Alpha-1 Antitrypsin Deficiency in a Pediatric Patient  Academic Article
• Long-term outcome of a pediatric-inspired regimen used for adults aged 18–50 years with newly diagnosed acute lymphoblastic leukemia  Academic Article
• Management of Children with Acute Lymphoblastic Leukemia by the Dana-Farber Cancer Institute Protocols  Academic Article
• Management of Ontario children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols.  Academic Article
• Medical Management of a Cervical Pregnancy: A Case Report  Academic Article
• Medical abortion: what does the research tell us?  Academic Article
• Methotrexate and Lung Disease in Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trials  Academic Article
• Methotrexate in rheumatoid arthritis. Impact on quality of life assessed by traditional standard-item and individualized patient preference health status questionnaires  Academic Article
• Methotrexate reduced pain and improved function in symptomatic knee osteoarthritis  Academic Article
• Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials  Academic Article
• Methotrexate/fluorouracil scheduling influences normal tissue toxicity but not antitumor effects in patients with squamous cell head and neck cancer: results from a randomized trial.  Academic Article
• Modification of in vivo methotrexate antitumor effect in L1210 leukemia by induced impairment of purine salvage  Academic Article
• Modulation of the antitumor effect of methotrexate by low-dose leucovorin in squamous cell head and neck cancer: a randomized placebo-controlled clinical trial.  Academic Article
• Neuropsychological Outcomes From a Randomized Trial of Triple Intrathecal Chemotherapy Compared With 18 Gy Cranial Radiation As CNS Treatment in Acute Lymphoblastic Leukemia: Findings From Dana-Farber Cancer Institute ALL Consortium Protocol 95-01  Academic Article
• New Applications for Traditional Drugs in Inflammatory Bowel Disease  Academic Article
• Ondansetron Compared with Dexamethasone and Metoclopramide as Antiemetics in the Chemotherapy of Breast Cancer with Cyclophosphamide, Methotrexate, and Fluorouracil  Academic Article
• Optimal Chemotherapy for Women With Breast Cancer: The Plot Thickens  Academic Article
• Optimal pathological response after neoadjuvant chemotherapy for muscle‐invasive bladder cancer: results from a global, multicentre collaboration  Academic Article
• Ovarian suppression/ablation in premenopausal ER-positive breast cancer patients. Issues and recommendations.  Academic Article
• Phase I/II Trial of Metronomic Chemotherapy With Daily Dalteparin and Cyclophosphamide, Twice-Weekly Methotrexate, and Daily Prednisone As Therapy for Metastatic Breast Cancer Using Vascular Endothelial Growth Factor and Soluble Vascular Endothelial Growth Factor Receptor Levels As Markers of Response  Academic Article
• Phase‐specific risks of outpatient visits, emergency visits, and hospitalizations during Children's Oncology Group‐based treatment for childhood acute lymphoblastic leukemia: A population‐based study  Academic Article
• Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster  Academic Article
• Potential effects of a national consensus statement on optimal treatment of early rheumatoid arthritis in Ontario  Academic Article
• Predicting Anthracycline Benefit: TOP2A and CEP17—Not Only but Also  Academic Article
• Primary brain T-cell lymphoma of the lymphoblastic type presenting as altered mental status  Academic Article
• Problems of Antiarthritic Therapy in the Elderly  Academic Article
• Prognostic accuracy of a novel methotrexate protocol for the resolution of tubal ectopic pregnancies  Academic Article
• Prospective randomized trial of one-hour sequential versus simultaneous methotrexate plus 5-fluorouracil in advanced and recurrent squamous cell head and neck cancer.  Academic Article
• Psoriasis in systemic lupus erythematosus: a single-center experience  Academic Article
• Purification and properties of dihydrofolate reductase from cultured mammalian cells  Academic Article
• Purification and properties of dihydrofolate reductase from methotrexate-sensitive and methotrexate-resistant Chinese hamster ovary cells  Academic Article
• Purification of tetrahydrofolate dehydrogenase by affinity chromatography  Academic Article
• Randomized Trial Comparing Cyclophosphamide, Epirubicin, and Fluorouracil With Cyclophosphamide, Methotrexate, and Fluorouracil in Premenopausal Women With Node-Positive Breast Cancer: Update of National Cancer Institute of Canada Clinical Trials Group Trial MA5  Academic Article
• Randomized trial of cyclophosphamide, methotrexate, and fluorouracil chemotherapy added to tamoxifen as adjuvant therapy in postmenopausal women with node-positive estrogen and/or progesterone receptor-positive breast cancer: a report of the National Cancer Institute of Canada Clinical Trials Group. Breast Cancer Site Group.  Academic Article
• Randomized trial of intensive cyclophosphamide, epirubicin, and fluorouracil chemotherapy compared with cyclophosphamide, methotrexate, and fluorouracil in premenopausal women with node-positive breast cancer. National Cancer Institute of Canada Clinical Trials Group.  Academic Article
• Rationale and design of the Cardiovascular Inflammation Reduction Trial: A test of the inflammatory hypothesis of atherothrombosis  Academic Article
• Real‐World Effectiveness of Common Treatment Strategies for Juvenile Idiopathic Arthritis: Results From a Canadian Cohort  Academic Article
• Reply  Academic Article
• Reply to: methotrexate and not much harm to the lungs by H. Yazici.  Academic Article
• Response times follow lognormal or gamma distribution in arthritis patients  Academic Article
• Responsiveness of Intrinsic Subtypes to Adjuvant Anthracycline Substitution in the NCIC.CTG MA.5 Randomized Trial  Academic Article
• Risk of Acute Leukemia Following Epirubicin-Based Adjuvant Chemotherapy: A Report From the National Cancer Institute of Canada Clinical Trials Group  Academic Article
• Risk of Menopause During the First Year After Breast Cancer Diagnosis  Academic Article
• Risk of liver injury among methotrexate users: A meta-analysis of randomised controlled trials  Academic Article
• STABILIZATION OF DIHYDROFOLATE REDUCTASE BY INHIBITORS IN VIVO AND IN VITRO  Academic Article
• Selection of adjuvant chemotherapy for treatment of node-positive breast cancer  Academic Article
• Selective assay for herpes simplex viruses expressing thymidine kinase  Academic Article
• Sensitivity to amphotericin B of a Naegleria sp. isolated from a case of primary amoebic meningoencephalitis  Academic Article
• Skeletal Morbidity in Childhood Acute Lymphoblastic Leukemia  Academic Article
• Studies with a 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP)-resistant L1210 leukemia cell line without cross-resistance to methotrexate  Academic Article
• Successful medical treatment of a hepatic pregnancy: a case report  Academic Article
• Survival results from a phase III study of simultaneous versus 1-hour sequential methotrexate—5-fluorouracil chemotherapy in head and neck cancer  Academic Article
• Systemic Immunomodulatory Treatments for Patients With Atopic Dermatitis  Academic Article
• Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy  Academic Article
• TIMP-1 in combination with HER2 and TOP2A for prediction of benefit from adjuvant anthracyclines in high-risk breast cancer patients  Academic Article
• Tamoxifen and conjugated estrogens (Premarin) followed by sequenced methotrexate and 5-FU in refractory advanced breast cancer.  Academic Article
• The Longterm Effect of Early Intensive Treatment of Seniors with Rheumatoid Arthritis: A Comparison of 2 Population-based Cohort Studies on Time to Joint Replacement Surgery  Academic Article
• The Thrombogenic Effect of Anticancer Drug Therapy in Women with Stage II Breast Cancer  Academic Article
• The case of methotrexate and the lung: Dr Jekyll and Mr Hyde  Academic Article
• The chemotherapy of granulosa cell tumors of the ovary: Experience of the wisconsin clinical cancer center  Academic Article
• The effect of systemic adjuvant chemotherapy on local breast recurrence in node positive breast cancer patients treated by lumpectomy without radiation  Academic Article
• The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces  Academic Article
• Timing of CMF chemotherapy in combination with tamoxifen in postmenopausal women with breast cancer: role of endocrine responsiveness of the tumor  Academic Article
• Tofacitinib in Combination With Methotrexate in Patients With Rheumatoid Arthritis: Clinical Efficacy, Radiographic, and Safety Outcomes From a Twenty‐Four–Month, Phase III Study  Academic Article
• Tolerance of Radiotherapy and Chemotherapy in Elderly Patients With Bladder Cancer  Academic Article
• Topoisomerase II alpha protein and responsiveness of breast cancer to adjuvant chemotherapy with CEF compared to CMF in the NCIC CTG randomized MA.5 adjuvant trial  Academic Article
• Treatment Strategies in Early Rheumatoid Arthritis Methotrexate Management: Results From a Prospective Cohort  Academic Article
• Treatment and its side effects in ANCA-associated vasculitides – Study based on POLVAS registry data  Academic Article
• Treatment of central nervous system tumors with methotrexate.  Academic Article
• Upadacitinib in patients with psoriatic arthritis and an inadequate response to non-biological therapy: 56-week data from the phase 3 SELECT-PsA 1 study  Academic Article
• Weekly Intravenous Methotrexate with Folinic Acid for Nonmetastatic Gestational Trophoblastic Neoplasia  Academic Article
• What drives the comparative effectiveness of biologics vs methotrexate in rheumatoid arthritis? Meta-regression and graphical inspection of suspected clinical factors  Academic Article