Methotrexate
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Genetic knockdown of a single organic anion transporter alters the expression of functionally related genes in Malpighian tubules ofDrosophila melanogaster Academic Article
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HER2and Responsiveness of Breast Cancer to Adjuvant Chemotherapy Academic Article
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Parent‐Reported Medication Side Effects and Their Impact on Health‐Related Quality of Life in Children With Juvenile Idiopathic Arthritis Conference Paper
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A 2.13 Å Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region Academic Article
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A novel methotrexate protocol for the resolution of tubal ectopic pregnancies; Methodological issues on prognostic studies: Response Academic Article
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A patient with primary sclerosing cholangitis ponders pulse: Methotrexate paper Academic Article
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A randomized trial comparing 12 weeks versus 36 weeks of adjuvant chemotherapy in stage II breast cancer. Academic Article
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Addition of anti-thymocyte globulin to standard graft-versus-host disease prophylaxis versus standard treatment alone in patients with haematological malignancies undergoing transplantation from unrelated donors: final analysis of a randomised, open-label, multicentre, phase 3 trial Academic Article
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Adjuvant Chemotherapy for Breast Cancer — 30 Years Later Academic Article
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Adjuvant Therapy for Premenopausal Women With Breast Cancer: Is It Time for Another Paradigm Shift? Academic Article
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Adjuvant chemotherapy with CEF versus CMF for node-positive breast cancer. Academic Article
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Adverse Drug Reactions in Canada in 2009–2018: Insights from the Canada Vigilance Database Academic Article
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Analysis of dose intensity for adjuvant chemotherapy trials in stage II breast cancer. Academic Article
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Analysis of dose intensity for chemotherapy in early (stage II) and advanced breast cancer. Academic Article
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Assessment of the cardioprotective effect of liraglutide on methotrexate induced cardiac dysfunction through suppression of inflammation and enhancement of angiogenesis in rats. Academic Article
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Associations Between Methotrexate Use and the Risk of Cardiovascular Events in Patients with Elderly-onset Rheumatoid Arthritis Academic Article
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Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Luminal Crohn’s Disease Academic Article
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Case 216: Hypertrophic Spinal Pachymeningitis Academic Article
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Cervical Ectopic Pregnancy Complicated by Escherichia Coli Septicemia: A Case Report Academic Article
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Clinical application of the concept of methotrexate plus 5-FU sequence-dependent "synergy": how good is the evidence? Academic Article
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Clinical pharmacology of gold Academic Article
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Combination Therapy With Methotrexate in Inflammatory Bowel Disease: Time to COMMIT? Academic Article
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Combination antifol therapy: observations on the development of resistant L1210 leukemic cells in vivo. Academic Article
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Combination therapy of cyclosporine with methotrexate and gold in rheumatoid arthritis (2 pilot studies). Academic Article
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Combined methotrexate–dactinomycin: An effective therapy for low-risk gestational trophoblastic neoplasia Academic Article
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Comparing Canadian paediatric rheumatology practice to the 2019 ACR Juvenile Idiopathic Arthritis guidelines: results from the CAPRI Registry Academic Article
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Comparison of leucovorin protection from variety of antifolates in human lymphoid cell lines Academic Article
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Comparison of thymidine and folinic acid protection from methotrexate toxicity in human lymphoid cell lines. Academic Article
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Cost-effectiveness analysis of rituximab with methotrexate, cytarabine and thiotepa for the treatment of patients with primary central nervous system lymphoma Academic Article
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Current quality-of-life research challenges in arthritis relevant to the issue of clinical significance Academic Article
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Differential calcium leucovorin protection of human lymphoid cell lines from methotrexate Academic Article
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Ectopic Pregnancy in a Caesarean Scar: A Case Report Academic Article
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Editorial: methotrexate in patients with Crohn's disease refractory to anti‐TNF therapy—moving backwards yet forward? Academic Article
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Effect of Concomitant Disease-modifying Antirheumatic Drugs and Methotrexate Administration Route on Biologic Treatment Durability in Rheumatoid Arthritis: OBRI Cohort Results Academic Article
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Effectiveness of antibacterial prophylaxis during induction chemotherapy in children with acute lymphoblastic leukemia Academic Article
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Effects of a treatment gap during adjuvant chemotherapy in node-positive breast cancer: results of International Breast Cancer Study Group (IBCSG) Trials 13-93 and 14-93 Academic Article
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Effects of acute or chronic exposure to dietary organic anions on secretion of methotrexate and salicylate by Malpighian tubules ofDrosophila melanogasterlarvae Academic Article
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Efficacy of Immunosuppressive Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis Academic Article
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Efficacy of certolizumab pegol across baseline rheumatoid factor subgroups in patients with rheumatoid arthritis: Post‐hoc analysis of clinical trials Academic Article
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First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis Academic Article
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Fluoride therapy in prevention of rheumatoid arthritis induced bone loss. Academic Article
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Graft-versus-host disease following marrow transplantation for aplastic anemia: different impact of two GVHD prevention strategies Academic Article
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Hepatotoxicity Caused by Methotrexate Therapy in Children with Inflammatory Bowel Disease Academic Article
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Heterogeneity in Patient Characteristics and Differences in Treatment Across 4 Canadian Rheumatoid Arthritis Cohorts Academic Article
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High Incidence of Vertebral Fractures in Children With Acute Lymphoblastic Leukemia 12 Months After the Initiation of Therapy Academic Article
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High-Dose Methotrexate for Gestational Trophoblastic Disease Academic Article
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Improvement in health utility among patients with rheumatoid arthritis treated with adalimumab (a human anti-TNF monoclonal antibody) plus methotrexate Academic Article
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Incidence and Prognostic Impact of Amenorrhea During Adjuvant Therapy in High-Risk Premenopausal Breast Cancer: Analysis of a National Cancer Institute of Canada Clinical Trials Group Study—NCIC CTG MA.5 Academic Article
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Increased thromboembolic complications with concurrent tamoxifen and chemotherapy in a randomized trial of adjuvant therapy for women with breast cancer. National Cancer Institute of Canada Clinical Trials Group Breast Cancer Site Group. Academic Article
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Influence of One Human Leukocyte Antigen Mismatch on Outcome of Allogeneic Bone Marrow Transplantation from Related Donors Academic Article
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Interactions between detoxification mechanisms and excretion in Malpighian tubules ofDrosophila melanogaster Academic Article
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Interventions for cutaneous disease in systemic lupus erythematosus Academic Article
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Intramuscular Methotrexate-Induced Aseptic Meningitis Academic Article
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Late effects of high-dose methotrexate treatment in childhood cancer survivors—a systematic review Academic Article
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Limited GPA and Alpha-1 Antitrypsin Deficiency in a Pediatric Patient Academic Article
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Long-term outcome of a pediatric-inspired regimen used for adults aged 18–50 years with newly diagnosed acute lymphoblastic leukemia Academic Article
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Management of Children with Acute Lymphoblastic Leukemia by the Dana-Farber Cancer Institute Protocols Academic Article
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Management of Ontario children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols. Academic Article
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Medical Management of a Cervical Pregnancy: A Case Report Academic Article
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Medical abortion: what does the research tell us? Academic Article
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Methotrexate and Lung Disease in Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trials Academic Article
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Methotrexate in rheumatoid arthritis. Impact on quality of life assessed by traditional standard-item and individualized patient preference health status questionnaires Academic Article
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Methotrexate reduced pain and improved function in symptomatic knee osteoarthritis Academic Article
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Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials Academic Article
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Methotrexate/fluorouracil scheduling influences normal tissue toxicity but not antitumor effects in patients with squamous cell head and neck cancer: results from a randomized trial. Academic Article
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Modification of in vivo methotrexate antitumor effect in L1210 leukemia by induced impairment of purine salvage Academic Article
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Modulation of the antitumor effect of methotrexate by low-dose leucovorin in squamous cell head and neck cancer: a randomized placebo-controlled clinical trial. Academic Article
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Neuropsychological Outcomes From a Randomized Trial of Triple Intrathecal Chemotherapy Compared With 18 Gy Cranial Radiation As CNS Treatment in Acute Lymphoblastic Leukemia: Findings From Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 Academic Article
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New Applications for Traditional Drugs in Inflammatory Bowel Disease Academic Article
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Ondansetron Compared with Dexamethasone and Metoclopramide as Antiemetics in the Chemotherapy of Breast Cancer with Cyclophosphamide, Methotrexate, and Fluorouracil Academic Article
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Optimal Chemotherapy for Women With Breast Cancer: The Plot Thickens Academic Article
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Optimal pathological response after neoadjuvant chemotherapy for muscle‐invasive bladder cancer: results from a global, multicentre collaboration Academic Article
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Ovarian suppression/ablation in premenopausal ER-positive breast cancer patients. Issues and recommendations. Academic Article
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Phase I/II Trial of Metronomic Chemotherapy With Daily Dalteparin and Cyclophosphamide, Twice-Weekly Methotrexate, and Daily Prednisone As Therapy for Metastatic Breast Cancer Using Vascular Endothelial Growth Factor and Soluble Vascular Endothelial Growth Factor Receptor Levels As Markers of Response Academic Article
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Phase‐specific risks of outpatient visits, emergency visits, and hospitalizations during Children's Oncology Group‐based treatment for childhood acute lymphoblastic leukemia: A population‐based study Academic Article
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Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster Academic Article
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Potential effects of a national consensus statement on optimal treatment of early rheumatoid arthritis in Ontario Academic Article
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Predicting Anthracycline Benefit: TOP2A and CEP17—Not Only but Also Academic Article
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Prevalence and significance of large granular lymphocytes in patients with immune thrombocytopenia Academic Article
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Primary brain T-cell lymphoma of the lymphoblastic type presenting as altered mental status Academic Article
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Problems of Antiarthritic Therapy in the Elderly Academic Article
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Prognostic accuracy of a novel methotrexate protocol for the resolution of tubal ectopic pregnancies Academic Article
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Prospective randomized trial of one-hour sequential versus simultaneous methotrexate plus 5-fluorouracil in advanced and recurrent squamous cell head and neck cancer. Academic Article
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Psoriasis in systemic lupus erythematosus: a single-center experience Academic Article
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Purification and properties of dihydrofolate reductase from cultured mammalian cells Academic Article
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Purification and properties of dihydrofolate reductase from methotrexate-sensitive and methotrexate-resistant Chinese hamster ovary cells Academic Article
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Purification of tetrahydrofolate dehydrogenase by affinity chromatography Academic Article
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Randomized Trial Comparing Cyclophosphamide, Epirubicin, and Fluorouracil With Cyclophosphamide, Methotrexate, and Fluorouracil in Premenopausal Women With Node-Positive Breast Cancer: Update of National Cancer Institute of Canada Clinical Trials Group Trial MA5 Academic Article
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Randomized trial of cyclophosphamide, methotrexate, and fluorouracil chemotherapy added to tamoxifen as adjuvant therapy in postmenopausal women with node-positive estrogen and/or progesterone receptor-positive breast cancer: a report of the National Cancer Institute of Canada Clinical Trials Group. Breast Cancer Site Group. Academic Article
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Randomized trial of intensive cyclophosphamide, epirubicin, and fluorouracil chemotherapy compared with cyclophosphamide, methotrexate, and fluorouracil in premenopausal women with node-positive breast cancer. National Cancer Institute of Canada Clinical Trials Group. Academic Article
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Rationale and design of the Cardiovascular Inflammation Reduction Trial: A test of the inflammatory hypothesis of atherothrombosis Academic Article
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Real‐World Effectiveness of Common Treatment Strategies for Juvenile Idiopathic Arthritis: Results From a Canadian Cohort Academic Article
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Reply Academic Article
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Reply to: methotrexate and not much harm to the lungs by H. Yazici. Academic Article
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Response times follow lognormal or gamma distribution in arthritis patients Academic Article
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Responsiveness of Intrinsic Subtypes to Adjuvant Anthracycline Substitution in the NCIC.CTG MA.5 Randomized Trial Academic Article
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Risk of Acute Leukemia Following Epirubicin-Based Adjuvant Chemotherapy: A Report From the National Cancer Institute of Canada Clinical Trials Group Academic Article
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Risk of Menopause During the First Year After Breast Cancer Diagnosis Academic Article
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Risk of liver injury among methotrexate users: A meta-analysis of randomised controlled trials Academic Article
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STABILIZATION OF DIHYDROFOLATE REDUCTASE BY INHIBITORS IN VIVO AND IN VITRO Academic Article
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Selection of adjuvant chemotherapy for treatment of node-positive breast cancer Academic Article
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Selective assay for herpes simplex viruses expressing thymidine kinase Academic Article
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Sensitivity to amphotericin B of a Naegleria sp. isolated from a case of primary amoebic meningoencephalitis Academic Article
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Skeletal Morbidity in Childhood Acute Lymphoblastic Leukemia Academic Article
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Studies with a 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP)-resistant L1210 leukemia cell line without cross-resistance to methotrexate Academic Article
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Successful medical treatment of a hepatic pregnancy: a case report Academic Article
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Survival results from a phase III study of simultaneous versus 1-hour sequential methotrexate—5-fluorouracil chemotherapy in head and neck cancer Academic Article
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Systemic Immunomodulatory Treatments for Patients With Atopic Dermatitis Academic Article
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Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy Academic Article
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TIMP-1 in combination with HER2 and TOP2A for prediction of benefit from adjuvant anthracyclines in high-risk breast cancer patients Academic Article
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Tamoxifen and conjugated estrogens (Premarin) followed by sequenced methotrexate and 5-FU in refractory advanced breast cancer. Academic Article
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The Longterm Effect of Early Intensive Treatment of Seniors with Rheumatoid Arthritis: A Comparison of 2 Population-based Cohort Studies on Time to Joint Replacement Surgery Academic Article
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The Thrombogenic Effect of Anticancer Drug Therapy in Women with Stage II Breast Cancer Academic Article
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The case of methotrexate and the lung: Dr Jekyll and Mr Hyde Academic Article
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The chemotherapy of granulosa cell tumors of the ovary: Experience of the wisconsin clinical cancer center Academic Article
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The effect of systemic adjuvant chemotherapy on local breast recurrence in node positive breast cancer patients treated by lumpectomy without radiation Academic Article
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The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces Academic Article
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Timing of CMF chemotherapy in combination with tamoxifen in postmenopausal women with breast cancer: role of endocrine responsiveness of the tumor Academic Article
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Tofacitinib in Combination With Methotrexate in Patients With Rheumatoid Arthritis: Clinical Efficacy, Radiographic, and Safety Outcomes From a Twenty‐Four–Month, Phase III Study Academic Article
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Tolerance of Radiotherapy and Chemotherapy in Elderly Patients With Bladder Cancer Academic Article
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Topoisomerase II alpha protein and responsiveness of breast cancer to adjuvant chemotherapy with CEF compared to CMF in the NCIC CTG randomized MA.5 adjuvant trial Academic Article
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Treatment Strategies in Early Rheumatoid Arthritis Methotrexate Management: Results From a Prospective Cohort Academic Article
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Treatment and its side effects in ANCA-associated vasculitides – Study based on POLVAS registry data Academic Article
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Treatment of central nervous system tumors with methotrexate. Academic Article
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Upadacitinib in patients with psoriatic arthritis and an inadequate response to non-biological therapy: 56-week data from the phase 3 SELECT-PsA 1 study Academic Article
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Weekly Intravenous Methotrexate with Folinic Acid for Nonmetastatic Gestational Trophoblastic Neoplasia Academic Article
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What drives the comparative effectiveness of biologics vs methotrexate in rheumatoid arthritis? Meta-regression and graphical inspection of suspected clinical factors Academic Article