Methotrexate Concept

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• A 2.13 Å Structure ofE. coliDihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region  Academic Article
• A patient with primary sclerosing cholangitis ponders pulse: Methotrexate paper  Academic Article
• A randomized trial comparing 12 weeks versus 36 weeks of adjuvant chemotherapy in stage II breast cancer.  Academic Article
• Addition of anti-thymocyte globulin to standard graft-versus-host disease prophylaxis versus standard treatment alone in patients with haematological malignancies undergoing transplantation from unrelated donors: final analysis of a randomised, open-label, multicentre, phase 3 trial  Academic Article
• Adjuvant Chemotherapy for Breast Cancer — 30 Years Later  Academic Article
• Adjuvant Therapy for Premenopausal Women With Breast Cancer: Is It Time for Another Paradigm Shift?  Academic Article
• Analysis of dose intensity for adjuvant chemotherapy trials in stage II breast cancer.  Academic Article
• Analysis of dose intensity for chemotherapy in early (stage II) and advanced breast cancer.  Academic Article
• Associations Between Methotrexate Use and the Risk of Cardiovascular Events in Patients with Elderly-onset Rheumatoid Arthritis  Academic Article
• Case 216: Hypertrophic Spinal Pachymeningitis  Academic Article
• Cervical Ectopic Pregnancy Complicated by Escherichia Coli Septicemia: A Case Report  Academic Article
• Clinical application of the concept of methotrexate plus 5-FU sequence-dependent "synergy": how good is the evidence?  Academic Article
• Clinical pharmacology of gold  Academic Article
• Clinical responsiveness of self-report functional assessment measures for children with juvenile idiopathic arthritis undergoing intraarticular corticosteroid injections  Academic Article
• Combination Therapy With Methotrexate in Inflammatory Bowel Disease: Time to COMMIT?  Academic Article
• Combination antifol therapy: observations on the development of resistant L1210 leukemic cells in vivo.  Academic Article
• Combination therapy of cyclosporine with methotrexate and gold in rheumatoid arthritis (2 pilot studies).  Academic Article
• Combined methotrexate–dactinomycin: An effective therapy for low-risk gestational trophoblastic neoplasia  Academic Article
• Comparison of leucovorin protection from variety of antifolates in human lymphoid cell lines  Academic Article
• Comparison of thymidine and folinic acid protection from methotrexate toxicity in human lymphoid cell lines.  Academic Article
• Current quality-of-life research challenges in arthritis relevant to the issue of clinical significance  Academic Article
• Differential calcium leucovorin protection of human lymphoid cell lines from methotrexate  Academic Article
• Ectopic Pregnancy in a Caesarean Scar: A Case Report  Academic Article
• Effect of Concomitant Disease-modifying Antirheumatic Drugs and Methotrexate Administration Route on Biologic Treatment Durability in Rheumatoid Arthritis: OBRI Cohort Results  Academic Article
• Effectiveness of antibacterial prophylaxis during induction chemotherapy in children with acute lymphoblastic leukemia  Academic Article
• Effects of a treatment gap during adjuvant chemotherapy in node-positive breast cancer: results of International Breast Cancer Study Group (IBCSG) Trials 13-93 and 14-93  Academic Article
• Effects of acute or chronic exposure to dietary organic anions on secretion of methotrexate and salicylate by Malpighian tubules ofDrosophila melanogasterlarvae  Academic Article
• Efficacy of Immunosuppressive Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis  Academic Article
• First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis  Academic Article
• Fluoride therapy in prevention of rheumatoid arthritis induced bone loss.  Academic Article
• Genetic knockdown of a single organic anion transporter alters the expression of functionally related genes in Malpighian tubules of Drosophila melanogaster  Academic Article
• Graft-versus-host disease following marrow transplantation for aplastic anemia: different impact of two GVHD prevention strategies  Academic Article
• HER2and Responsiveness of Breast Cancer to Adjuvant Chemotherapy  Academic Article
• Hepatotoxicity Caused by Methotrexate Therapy in Children with Inflammatory Bowel Disease  Academic Article
• High Incidence of Vertebral Fractures in Children With Acute Lymphoblastic Leukemia 12 Months After the Initiation of Therapy  Academic Article
• High-Dose Methotrexate for Gestational Trophoblastic Disease  Academic Article
• Incidence and Prognostic Impact of Amenorrhea During Adjuvant Therapy in High-Risk Premenopausal Breast Cancer: Analysis of a National Cancer Institute of Canada Clinical Trials Group Study—NCIC CTG MA.5  Academic Article
• Increased thromboembolic complications with concurrent tamoxifen and chemotherapy in a randomized trial of adjuvant therapy for women with breast cancer. National Cancer Institute of Canada Clinical Trials Group Breast Cancer Site Group.  Academic Article
• Influence of One Human Leukocyte Antigen Mismatch on Outcome of Allogeneic Bone Marrow Transplantation from Related Donors  Academic Article
• Interactions between detoxification mechanisms and excretion in Malpighian tubules of Drosophila melanogaster  Academic Article
• Intramuscular Methotrexate-Induced Aseptic Meningitis  Academic Article
• Limited GPA and Alpha-1 Antitrypsin Deficiency in a Pediatric Patient  Academic Article
• Long-term outcome of a pediatric-inspired regimen used for adults aged 18–50 years with newly diagnosed acute lymphoblastic leukemia  Academic Article
• Long-term results of a pilot study for the treatment of advanced unresectable head and neck tumors by combination chemotherapy and split course radiotherapy.  Academic Article
• Management of Children with Acute Lymphoblastic Leukemia by the Dana-Farber Cancer Institute Protocols  Academic Article
• Management of Ontario children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols.  Academic Article
• Medical Management of a Cervical Pregnancy: A Case Report  Academic Article
• Medical abortion: what does the research tell us?  Academic Article
• Methotrexate and Lung Disease in Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trials  Academic Article
• Methotrexate for Rheumatoid Arthritis  Academic Article
• Methotrexate in Rheumatoid Arthritis  Academic Article
• Methotrexate in Rheumatoid Arthritis  Academic Article
• Methotrexate in rheumatoid arthritis. Impact on quality of life assessed by traditional standard-item and individualized patient preference health status questionnaires  Academic Article
• Methotrexate reduced pain and improved function in symptomatic knee osteoarthritis  Academic Article
• Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials  Academic Article
• Methotrexate/fluorouracil scheduling influences normal tissue toxicity but not antitumor effects in patients with squamous cell head and neck cancer: results from a randomized trial.  Academic Article
• Modification of in vivo methotrexate antitumor effect in L1210 leukemia by induced impairment of purine salvage  Academic Article
• Modulation of the antitumor effect of methotrexate by low-dose leucovorin in squamous cell head and neck cancer: a randomized placebo-controlled clinical trial.  Academic Article
• Neuropsychological Outcomes From a Randomized Trial of Triple Intrathecal Chemotherapy Compared With 18 Gy Cranial Radiation As CNS Treatment in Acute Lymphoblastic Leukemia: Findings From Dana-Farber Cancer Institute ALL Consortium Protocol 95-01  Academic Article
• New Applications for Traditional Drugs in Inflammatory Bowel Disease  Academic Article
• Ondansetron Compared with Dexamethasone and Metoclopramide as Antiemetics in the Chemotherapy of Breast Cancer with Cyclophosphamide, Methotrexate, and Fluorouracil  Academic Article
• Optimal Chemotherapy for Women With Breast Cancer: The Plot Thickens  Academic Article
• Ovarian suppression/ablation in premenopausal ER-positive breast cancer patients. Issues and recommendations.  Academic Article
• Phase I/II Trial of Metronomic Chemotherapy With Daily Dalteparin and Cyclophosphamide, Twice-Weekly Methotrexate, and Daily Prednisone As Therapy for Metastatic Breast Cancer Using Vascular Endothelial Growth Factor and Soluble Vascular Endothelial Growth Factor Receptor Levels As Markers of Response  Academic Article
• Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster  Academic Article
• Potential effects of a national consensus statement on optimal treatment of early rheumatoid arthritis in Ontario  Academic Article
• Predicting Anthracycline Benefit: TOP2A and CEP17—Not Only but Also  Academic Article
• Primary brain T-cell lymphoma of the lymphoblastic type presenting as altered mental status  Academic Article
• Problems of Antiarthritic Therapy in the Elderly  Academic Article
• Prospective randomized trial of one-hour sequential versus simultaneous methotrexate plus 5-fluorouracil in advanced and recurrent squamous cell head and neck cancer.  Academic Article
• Purification and properties of dihydrofolate reductase from cultured mammalian cells  Academic Article
• Purification and properties of dihydrofolate reductase from methotrexate-sensitive and methotrexate-resistant Chinese hamster ovary cells  Academic Article
• Purification of tetrahydrofolate dehydrogenase by affinity chromatography  Academic Article
• Randomized Trial Comparing Cyclophosphamide, Epirubicin, and Fluorouracil With Cyclophosphamide, Methotrexate, and Fluorouracil in Premenopausal Women With Node-Positive Breast Cancer: Update of National Cancer Institute of Canada Clinical Trials Group Trial MA5  Academic Article
• Randomized trial of cyclophosphamide, methotrexate, and fluorouracil chemotherapy added to tamoxifen as adjuvant therapy in postmenopausal women with node-positive estrogen and/or progesterone receptor-positive breast cancer: a report of the National Cancer Institute of Canada Clinical Trials Group. Breast Cancer Site Group.  Academic Article
• Randomized trial of intensive cyclophosphamide, epirubicin, and fluorouracil chemotherapy compared with cyclophosphamide, methotrexate, and fluorouracil in premenopausal women with node-positive breast cancer. National Cancer Institute of Canada Clinical Trials Group.  Academic Article
• Rationale and design of the Cardiovascular Inflammation Reduction Trial: A test of the inflammatory hypothesis of atherothrombosis  Academic Article
• Reply  Academic Article
• Reply to: methotrexate and not much harm to the lungs by H. Yazici.  Academic Article
• Response times follow lognormal or gamma distribution in arthritis patients  Academic Article
• Responsiveness of Intrinsic Subtypes to Adjuvant Anthracycline Substitution in the NCIC.CTG MA.5 Randomized Trial  Academic Article
• Risk of Acute Leukemia Following Epirubicin-Based Adjuvant Chemotherapy: A Report From the National Cancer Institute of Canada Clinical Trials Group  Academic Article
• Risk of Menopause During the First Year After Breast Cancer Diagnosis  Academic Article
• Risk of liver injury among methotrexate users: A meta-analysis of randomised controlled trials  Academic Article
• STABILIZATION OF DIHYDROFOLATE REDUCTASE BY INHIBITORS IN VIVO AND IN VITRO  Academic Article
• Selection of adjuvant chemotherapy for treatment of node-positive breast cancer  Academic Article
• Selective assay for herpes simplex viruses expressing thymidine kinase.  Academic Article
• Sensitivity to amphotericin B of a Naegleria sp. isolated from a case of primary amoebic meningoencephalitis  Academic Article
• Skeletal Morbidity in Childhood Acute Lymphoblastic Leukemia  Academic Article
• Studies with a 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP)-resistant L1210 leukemia cell line without cross-resistance to methotrexate  Academic Article
• Successful medical treatment of a hepatic pregnancy: a case report  Academic Article
• Survival results from a phase III study of simultaneous versus 1-hour sequential methotrexate—5-fluorouracil chemotherapy in head and neck cancer  Academic Article
• Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Early Breast Cancer Trialists' Collaborative Group.  Academic Article
• TIMP-1 in combination with HER2 and TOP2A for prediction of benefit from adjuvant anthracyclines in high-risk breast cancer patients  Academic Article
• Tamoxifen and conjugated estrogens (Premarin) followed by sequenced methotrexate and 5-FU in refractory advanced breast cancer.  Academic Article
• The Longterm Effect of Early Intensive Treatment of Seniors with Rheumatoid Arthritis: A Comparison of 2 Population-based Cohort Studies on Time to Joint Replacement Surgery  Academic Article
• The Thrombogenic Effect of Anticancer Drug Therapy in Women with Stage II Breast Cancer  Academic Article
• The chemotherapy of granulosa cell tumors of the ovary: Experience of the wisconsin clinical cancer center  Academic Article
• The effect of systemic adjuvant chemotherapy on local breast recurrence in node positive breast cancer patients treated by lumpectomy without radiation  Academic Article
• The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces  Academic Article
• Timing of CMF chemotherapy in combination with tamoxifen in postmenopausal women with breast cancer: role of endocrine responsiveness of the tumor  Academic Article
• Tofacitinib in Combination With Methotrexate in Patients With Rheumatoid Arthritis: Clinical Efficacy, Radiographic, and Safety Outcomes From a Twenty‐Four–Month, Phase III Study  Academic Article
• Tolerance of Radiotherapy and Chemotherapy in Elderly Patients With Bladder Cancer  Academic Article
• Topoisomerase II alpha protein and responsiveness of breast cancer to adjuvant chemotherapy with CEF compared to CMF in the NCIC CTG randomized MA.5 adjuvant trial  Academic Article
• Treatment of central nervous system tumors with methotrexate.  Academic Article
• Weekly Intravenous Methotrexate with Folinic Acid for Nonmetastatic Gestational Trophoblastic Neoplasia  Academic Article
• What drives the comparative effectiveness of biologics vs methotrexate in rheumatoid arthritis? Meta-regression and graphical inspection of suspected clinical factors  Academic Article