Journal article
Hepatotoxicity Caused by Methotrexate Therapy in Children with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
Abstract
BACKGROUND: Methotrexate (MTX) is an immunomodulator used in pediatric inflammatory bowel disease (IBD) maintenance regimens. However, MTX use is associated with liver toxicity. We aimed to systematically review and meta-analyze the incidence of hepatotoxicity with MTX use among children with IBD.
METHODS: We searched MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials databases from 1946 to April 2013 for cohort …
Authors
Valentino PL; Church PC; Shah PS; Beyene J; Griffiths AM; Feldman BM; Kamath BM
Journal
Inflammatory Bowel Diseases, Vol. 20, No. 1, pp. 47–59
Publisher
Oxford University Press (OUP)
Publication Date
January 2014
DOI
10.1097/01.mib.0000436953.88522.3e
ISSN
1078-0998