Journal article
Neuropsychological Outcomes From a Randomized Trial of Triple Intrathecal Chemotherapy Compared With 18 Gy Cranial Radiation As CNS Treatment in Acute Lymphoblastic Leukemia: Findings From Dana-Farber Cancer Institute ALL Consortium Protocol 95-01
Abstract
PURPOSE: We evaluated late neuropsychological toxicity in children treated for standard-risk acute lymphoblastic leukemia (ALL) who were randomly assigned to receive either cranial radiation therapy (CRT) with double intrathecal (IT) chemotherapy or intensive triple IT chemotherapy (no CRT) as CNS-directed therapy.
PATIENTS AND METHODS: Between 1996 and 2000, 164 children with standard-risk ALL treated on Dana-Farber Cancer Institute Consortium …
Authors
Waber DP; Turek J; Catania L; Stevenson K; Robaey P; Romero I; Adams H; Alyman C; Jandet-Brunet C; Neuberg DS
Journal
Journal of Clinical Oncology, Vol. 25, No. 31, pp. 4914–4921
Publisher
American Society of Clinical Oncology (ASCO)
Publication Date
November 1, 2007
DOI
10.1200/jco.2007.10.8464
ISSN
0732-183X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Antineoplastic Combined Chemotherapy ProtocolsCentral Nervous System DiseasesCentral Nervous System NeoplasmsChildChild, PreschoolCranial IrradiationCytarabineFemaleGlucocorticoidsHumansHydrocortisoneInfantInjections, SpinalMaleMethotrexateNeuropsychological TestsPrecursor Cell Lymphoblastic Leukemia-Lymphoma