Risk of liver injury among methotrexate users: A meta-analysis of randomised controlled trials

Abstract

OBJECTIVE: Methotrexate is an effective treatment for a variety of inflammatory diseases. Robust evidence on the risk of serious liver injury is lacking. The aim of this study was to evaluate the relative risk and severity of liver disease among patients treated with methotrexate. METHODS: We searched PubMed and the Cochrane Central Register of Controlled Trials from 1 January 1990 to 24 April 2014 for double-blind randomised controlled trials …

Authors

Conway R; Low C; Coughlan RJ; O’Donnell MJ; Carey JJ

Journal

Seminars in Arthritis and Rheumatism, Vol. 45, No. 2, pp. 156–162

Publisher

Elsevier

Publication Date

October 2015

DOI

10.1016/j.semarthrit.2015.05.003

ISSN

0049-0172

Associated Experts

Martin O'Donnell

Associate Clinical Professor, Faculty of Health Sciences

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