Interleukin-4 Concept

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• β2-1 Fructan supplementation alters host immune responses in a manner consistent with increased exposure to microbial components: results from a double-blinded, randomised, cross-over study in healthy adults  Journal Articles
• IL‐6 mediates ER expansion during hyperpolarization of alternatively activated macrophages  Journal Articles
• PM10‐stimulated airway epithelial cells activate primary human dendritic cells independent of uric acid: Application of an in vitro model system exposing dendritic cells to airway epithelial cell‐conditioned media  Journal Articles
• A Single Intramuscular Injection with an Adenovirus- Expressing IL-12 Protects BALB/c Mice AgainstLeishmania majorInfection, While Treatment with an IL-4-Expressing Vector Increases Disease Susceptibility in B10.D2 Mice  Journal Articles
• A novel microbe-based treatment that attenuates the inflammatory profile in a mouse model of allergic airway disease  Journal Articles
• A phase I trial of adenovector-mediated delivery of interleukin-2 (AdIL-2) in high-risk localized prostate cancer  Journal Articles
• Adenoviral Vector-Mediated Overexpression of IL-4 in the Knee Joint of Mice with Collagen-Induced Arthritis Prevents Cartilage Destruction  Journal Articles
• Adenoviral Vectors Expressing Lymphotactin and Interleukin 2 or Lymphotactin and Interleukin 12 Synergize to Facilitate Tumor Regression in Murine Breast Cancer Models  Journal Articles
• Adenoviral-mediated Gene Transfer to Mouse Salivary Glands  Journal Articles
• Analysis of the Immune Responses of Mice to Infection withLeishmania braziliensis  Journal Articles
• Anti-IgE and Biologic Approaches for the Treatment of Asthma  Journal Articles
• Anti-interleukin-13 and anti-interleukin-4 agents versus placebo, anti-interleukin-5 or anti-immunoglobulin-E agents, for people with asthma  Journal Articles
• Antifibrotic Drug Nintedanib Inhibits CSF1R to Promote IL-4–associated Tissue Repair Macrophages  Journal Articles
• Basophils in airway disease  Journal Articles
• CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection  Journal Articles
• CD4⁺ T‐cell‐mediated anti‐tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis  Journal Articles
• CT and Functional MRI to Evaluate Airway Mucus in Severe Asthma  Journal Articles
• Chronic Immune Activation and CD4+ T Cell Lymphopenia in Healthy African Individuals: Perspectives for SARS-CoV-2 Vaccine Efficacy  Journal Articles
• Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity  Journal Articles
• Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder  Journal Articles
• Compartmentalized transgene expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation  Journal Articles
• Concurrent dual allergen exposure and its effects on airway hyperresponsiveness, inflammation and remodeling in mice  Journal Articles
• Critical Role for Signal Transducer and Activator of Transcription Factor 6 in Mediating Intestinal Muscle Hypercontractility and Worm Expulsion inTrichinella spiralis-Infected Mice  Journal Articles
• Cytokines or Their Antagonists for the Treatment of Asthma  Journal Articles
• Detection of precursor Th cells in mesenteric lymph nodes after oral immunization with protein antigen and cholera toxin  Journal Articles
• Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice.  Journal Articles
• Distinct immunohistochemical localization of IL-4 in human inflamed airway tissues. IL-4 is localized to eosinophils in vivo and is released by peripheral blood eosinophils.  Journal Articles
• Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes  Journal Articles
• Early Intestinal Th1 Inflammation and Mucosal T Cell Recruitment During Acute Graft-Versus-Host Reaction  Journal Articles
• Effects of adenoviral-mediated gene transfer of interleukin-10, interleukin-4, and transforming growth factor-β on the survival of axotomized retinal ganglion cells  Journal Articles
• Effects of inhaled ciclesonide on circulating T‐helper type 1/T‐helper type 2 cells in atopic asthmatics after allergen challenge  Journal Articles
• Effects of sand fly vector saliva on development of cutaneous lesions and the immune response to Leishmania braziliensis in BALB/c mice  Journal Articles
• Effects on brain tumor cell proliferation by an adenovirus vector that bears the Interleukin-4 gene  Journal Articles
• Engineering a Novel Stem Cells from Apical Papilla-Macrophages Organoid for Regenerative Endodontics  Journal Articles
• Enhanced In Vivo Immunogenicity Induced by an Antibody to the IL‐4 Receptor‐Associated gp200‐MR6 Molecule  Journal Articles
• Enhanced Immune Response to the Melanoma Antigen gp100 Using Recombinant Adenovirus-Transduced Dendritic Cells  Journal Articles
• Enhanced transepithelial antigen transport in intestine of allergic mice is mediated by IgE/CD23 and regulated by interleukin-4  Journal Articles
• Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments  Journal Articles
• Environmental influence on T cell receptor α gene rearrangement and expression in vitro  Journal Articles
• Eosinophil-derived IL-13 promotes emphysema  Journal Articles
• Evaluation of Inducible Costimulator/B7-Related Protein-1 as a Therapeutic Target in a Murine Model of Allergic Airway Inflammation  Journal Articles
• Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics.  Journal Articles
• Expression of functional cysteinyl leukotriene receptors by human basophils  Journal Articles
• Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning  Journal Articles
• Functional Expression of Neurokinin 1 Receptors on Mast Cells Induced by IL-4 and Stem Cell Factor  Journal Articles
• GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice.  Journal Articles
• Granulocyte Macrophage Colony–Stimulating Factor–Driven Respiratory Mucosal Sensitization Induces Th2 Differentiation and Function Independently of Interleukin-4  Journal Articles
• ICOS is essential for effective T-helper-cell responses  Journal Articles
• IL-12 gene transfer alters gut physiology and host immunity in nematode-infected mice  Journal Articles
• IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization  Journal Articles
• IL-4 and IL-13 Differentially Regulate TLR-Induced Eosinophil-Basophil Differentiation of Cord Blood CD34+ Progenitor Cells  Journal Articles
• IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion  Journal Articles
• IL-4 gene transfer to the small bowel serosa leads to intestinal inflammation and smooth muscle hyperresponsiveness  Journal Articles
• IL‐4 Is Not Involved in the Early MLN T‐cell Response to Antigen Given Orally with Cholera Toxin, but Those Cells Can Express IL‐4R  Journal Articles
• Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer  Journal Articles
• Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo  Journal Articles
• Influenza A Virus Specific T Cell Immunity in Humans during Aging  Journal Articles
• Inhibition of alloreactivity by mAb MR6: differential effects on IL-2- and IL-4-producing human T cells  Journal Articles
• Interactions of Hemopoietic Cytokines on Differentiation of HL-60 Cells  Journal Articles
• Interleukin (IL)-5 but Not Immunoglobulin E Reconstitutes Airway Inflammation and Airway Hyperresponsiveness in IL-4–Deficient Mice  Journal Articles
• Interleukin-4 and interleukin-10 polymorphisms and antituberculosis drug-induced hepatotoxicity in Chinese population  Journal Articles
• Interleukin-4- and -13-induced hypercontractility of human intestinal muscle cells-implication for motility changes in Crohn's disease  Journal Articles
• Interleukin-5 is a human basophilopoietin: induction of histamine content and basophilic differentiation of HL-60 cells and of peripheral blood basophil-eosinophil progenitors  Journal Articles
• Interleukins 4 and 13 Increase Intestinal Epithelial Permeability by a Phosphatidylinositol 3-Kinase Pathway  Journal Articles
• Interleukin‐4 and RANTES expression in maturing eosinophils derived from human cord blood CD34⁺ progenitors  Journal Articles
• Interleukin‐4 and interleukin‐13 prime migrational responses of haemopoietic progenitor cells to stromal cell‐derived factor‐1α  Journal Articles
• Lack of Both Types 1 and 2 Cytokines, Tissue Inflammatory Responses, and Immune Protection During Pulmonary Infection byMycobacterium bovisBacille Calmette-Guérin in IL-12-Deficient Mice  Journal Articles
• Mechanisms Underlying the Maintenance of Muscle Hypercontractility in a Model of Postinfective Gut Dysfunction  Journal Articles
• Modulation of Human Airway Smooth Muscle Migration by Lipid Mediators and Th-2 Cytokines  Journal Articles
• Monoclonal antibodies for the treatment of refractory asthma  Journal Articles
• Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects  Journal Articles
• Neural change inTrichinella-infected mice is MHC II independent and involves M-CSF-derived macrophages  Journal Articles
• Neuromuscular regulation of T-cell activation  Journal Articles
• Neuropeptides accentuate interleukin‐4 induced human immunoglobuline E synthesis in vitro  Journal Articles
• Neuropeptides are potent modulators of human in vitro immunoglobulin E synthesis  Journal Articles
• Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: Regulation of the type-II IL-4 receptor chains IL-4Rα and IL-13Rα1  Journal Articles
• Oncostatin-M Up-Regulates VCAM-1 and Synergizes with IL-4 in Eotaxin Expression: Involvement of STAT6  Journal Articles
• Preferential Proliferation and Differentiation of Double-Positive Thymocytes into CD8+ Single-Positive Thymocytes in a Novel Cell Culture Medium  Journal Articles
• Proinflammatory properties of IL-4 in the intestinal microenvironment  Journal Articles
• Protection Against Experimental Autoimmune Encephalomyelitis Generated by a Recombinant Adenovirus Vector Expressing the Vβ8.2 TCR Is Disrupted by Coadministration with Vectors Expressing Either IL-4 or -10  Journal Articles
• Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles  Journal Articles
• Reassessing the Th2 cytokine basis of asthma  Journal Articles
• Resolution of an Infection with Leishmania braziliensis Confers Complete Protection to a Subsequent Challenge with Leishmania major in BALB/c Mice  Journal Articles
• Role for IL-4 in macromolecular transport across human intestinal epithelium  Journal Articles
• Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells  Journal Articles
• STAT-6 Is an Absolute Requirement for Murine Rejection of Hymenolepis diminuta  Journal Articles
• Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR α‐chain CDR3 loop  Journal Articles
• Separate roles of IL‐6 and oncostatin M in mouse macrophage polarization in vitro and in vivo  Journal Articles
• T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes  Journal Articles
• The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses  Journal Articles
• The effects of blockade of interleukin 2 receptors and interleukin 4 receptors on cytokine production  Journal Articles
• The pharmacological modulation of allergen-induced asthma  Journal Articles
• The protective effect of the vagus nerve in a murine model of chronic relapsing colitis  Journal Articles
• Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease.  Journal Articles
• Thymopentin Modulates Th1 and Th2 Cytokine Response and Host Survival in Experimental Injury  Journal Articles
• Transgene-induced production of IL-4 alters the development and collagen expression of T helper cell 1-type pulmonary granulomas.  Journal Articles
• Transient Gene Transfer of Non-ELR Chemokines to Rodent Lung Induces Mononuclear Cell Accumulation and Activation  Journal Articles
• Treatment of severe systemic lupus erythematosus with high-dose chemotherapy and haemopoietic stem-cell transplantation: a phase I study  Journal Articles
• Type 2 Cytokines in the Pathogenesis of Sustained Airway Dysfunction and Airway Remodeling in Mice  Journal Articles