Journal article
Treatment of severe systemic lupus erythematosus with high-dose chemotherapy and haemopoietic stem-cell transplantation: a phase I study
Abstract
BACKGROUND: Patients with systemic lupus erythematosus (SLE) who experience persistent multiorgan dysfunction, despite standard doses of intravenous cyclophosphamide, represent a subset of patients at high risk of early death. We investigated the safety and efficacy of immune suppression and autologous haemopoietic stem-cell infusion to treat such patients.
METHODS: From 1996, we selected patients with persistent SLE despite use of …
Authors
Traynor AE; Schroeder J; Rosa RM; Cheng D; Stefka J; Mujais S; Baker S; Burt RK
Journal
The Lancet, Vol. 356, No. 9231, pp. 701–707
Publisher
Elsevier
Publication Date
August 2000
DOI
10.1016/s0140-6736(00)02627-1
ISSN
0140-6736
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAntigens, CDAntigens, Differentiation, T-LymphocyteAntineoplastic Agents, AlkylatingBlood Cell CountCreatinineCyclophosphamideEnzyme-Linked Immunosorbent AssayFlow CytometryHematopoietic Stem Cell TransplantationHumansInterferon-gammaInterleukin-4Lectins, C-TypeLupus Erythematosus, SystemicMiddle AgedTreatment Outcome