Journal article
Protection Against Experimental Autoimmune Encephalomyelitis Generated by a Recombinant Adenovirus Vector Expressing the Vβ8.2 TCR Is Disrupted by Coadministration with Vectors Expressing Either IL-4 or -10
Abstract
Adenovirus vectors are increasingly being used for genetic vaccination and may prove highly suitable for intervention in different pathological conditions due to their capacity to generate high level, transient gene expression. In this study, we report the use of a recombinant adenovirus vector to induce regulatory responses for the prevention of autoimmune diseases through transient expression of a TCR beta-chain. Immunization of B10.PL mice …
Authors
Braciak TA; Pedersen B; Chin J; Hsiao C; Ward ES; Maricic I; Jahng A; Graham FL; Gauldie J; Sercarz EE
Journal
The Journal of Immunology, Vol. 170, No. 2, pp. 765–774
Publisher
Oxford University Press (OUP)
Publication Date
January 15, 2003
DOI
10.4049/jimmunol.170.2.765
ISSN
0022-1767
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adenoviruses, HumanAmino Acid SequenceAnimalsCell DivisionCytokinesDose-Response Relationship, ImmunologicEncephalomyelitis, Autoimmune, ExperimentalFemaleGenetic VectorsHumansImmunizationImmunodominant EpitopesImmunoglobulin Variable RegionImmunophenotypingInjections, IntramuscularInjections, IntraperitonealInterleukin-10Interleukin-4Lymphocyte ActivationMiceMice, Inbred C57BLMolecular Sequence DataMyelin Basic ProteinPeptide FragmentsReceptors, Antigen, T-Cell, alpha-betaRecombination, GeneticT-Lymphocyte SubsetsTh1 Cells