Clinical Trials, Phase III as Topic Concept

subject area of

• SQ sublingual immunotherapy tablets for children with allergic rhinitis: A review of phase three trials  Journal Articles
• A Guide to Implementation Science for Phase 3 Clinical Trialists: Designing Trials for Evidence Uptake.  Journal Articles
• A critical appraisal of bleeding events reported in venous thromboembolism prevention trials of patients undergoing hip and knee arthroplasty  Journal Articles
• A randomised placebo-controlled trial of the effectiveness of early metformin in addition to usual care in the reduction of gestational diabetes mellitus effects (EMERGE): study protocol  Journal Articles
• A systematic review of contemporary trials of anticoagulants in orthopaedic thromboprophylaxis: suggestions for a radical reappraisal  Journal Articles
• A tutorial on pilot studies: the what, why and how  Journal Articles
• Added value of health-related quality of life measurement in cancer clinical trials: the experience of the NCIC CTG  Journal Articles
• Alendronate for osteoporosis. Safe and efficacious nonhormonal therapy.  Journal Articles
• Andexanet alfa for the treatment of hemorrhage  Journal Articles
• Antacid therapy and disease outcomes in idiopathic pulmonary fibrosis: a pooled analysis  Journal Articles
• Association Between RECIST Changes and Survival in Patients with Metastatic Castration-resistant Prostate Cancer Receiving Docetaxel  Journal Articles
• Association of body weight with efficacy and safety outcomes in phase III randomized controlled trials of direct oral anticoagulants: a systematic review and meta‐analysis  Journal Articles
• Assumptions of Expected Benefits in Randomized Phase III Trials Evaluating Systemic Treatments for Cancer  Journal Articles
• Bivariate evaluation of thromboembolism and bleeding in clinical trials of anticoagulants in patients with atrial fibrillation  Journal Articles
• Bleeding Complications and Management on anticoagulant therapy  Journal Articles
• Bleeding with Direct Oral Anticoagulants vs Warfarin: Clinical Experience  Journal Articles
• Bleeding with direct oral anticoagulants vs warfarin: clinical experience  Journal Articles
• Bone Turnover Markers as Predictors of Skeletal Complications in Prostate Cancer, Lung Cancer, and Other Solid Tumors  Journal Articles
• Breaking the biomarker code: PD-L1 expression and checkpoint inhibition in advanced NSCLC  Journal Articles
• Burden of Proof for Tolvaptan in ADPKD  Journal Articles
• Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? Reflections From aDiabetes CareEditors’ Expert Forum  Journal Articles
• Central Nervous System–Specific Outcomes of Phase 3 Randomized Clinical Trials in Patients With Advanced Breast Cancer, Lung Cancer, and Melanoma  Journal Articles
• Chemotherapy for Relapsed Small Cell Lung Cancer: A Systematic Review and Practice Guideline  Journal Articles
• Chemotherapy for advanced non-small-cell lung cancer: how much benefit is enough?  Journal Articles
• Clinical Experience With the New Oral Anticoagulants for Treatment of Venous Thromboembolism  Journal Articles
• Clinical data gap between phase III clinical trials (pre-marketing) and phase IV (post-marketing) studies: evaluation of etanercept in rheumatoid arthritis.  Journal Articles
• Clinical trial design in metastatic breast cancer: a commentary.  Journal Articles
• Clinical trials of new anticoagulants.  Journal Articles
• Comparing mortality in patients with atrial fibrillation who are receiving a direct‐acting oral anticoagulant or warfarin: a meta‐analysis of randomized trials  Journal Articles
• Comparison of Outcomes of Phase II Studies and Subsequent Randomized Control Studies Using Identical Chemotherapeutic Regimens  Conferences
• Complementary Medicine Use Amongst Patients with Metastatic Cancer Enrolled in Phase III Clinical Trials  Journal Articles
• Consistency of Phase III Clinical Trial Abstracts Presented at an Annual Meeting of the American Society of Clinical Oncology Compared With Their Subsequent Full-Text Publications  Conferences
• Correlation of single arm versus randomised phase 2 oncology trial characteristics with phase 3 outcome  Journal Articles
• Cost-effectiveness of becaplermin for nonhealing neuropathic diabetic foot ulcers.  Journal Articles
• Dabigatran Etexilate: Future Directions in Anticoagulant Treatment  Journal Articles
• Dabigatran etexilate for prevention of venous thromboembolism  Journal Articles
• Dabigatran versus Warfarin for Acute Venous Thromboembolism in Elderly or Impaired Renal Function Patients: Pooled Analysis of RE-COVER and RE-COVER II  Journal Articles
• Dabigatran versus Warfarin for Acute Venous Thromboembolism in Elderly or Impaired Renal Function Patients: Pooled Analysis of RE-COVER and RE-COVER II.  Journal Articles
• Definition of clinically relevant non‐major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non‐surgical patients: communication from the SSC of the ISTH  Journal Articles
• Demographic, clinical, and patient-reported outcome data from 2 global, phase 3 trials of chronic cough  Journal Articles
• Design of the INPULSIS™ trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis  Journal Articles
• Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials  Journal Articles
• Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials.  Journal Articles
• Direct-acting antiviral therapies for hepatitis C genotype 1 infection: a multiple treatment comparison meta-analysis  Journal Articles
• Do alternative methods of measuring tumor size, including consideration of multicentric/multifocal disease, enhance prognostic information beyond TNM staging in women with early stage breast cancer: an analysis of the NCIC CTG MA.5 and MA.12 clinical trials  Journal Articles
• Economic analysis of a randomized phase III trial of gemcitabine plus vinorelbine compared with cisplatin plus vinorelbine or cisplatin plus gemcitabine for advanced non-small-cell lung cancer (Italian GEMVIN3/NCIC CTG BR14 trial)  Journal Articles
• Effect of Radiotherapy on Painful Bone Metastases  Journal Articles
• Effect of extended‐duration thromboprophylaxis on venous thromboembolism and major bleeding among acutely ill hospitalized medical patients: a bivariate analysis  Journal Articles
• Efficacy and safety of rolapitant for prevention of chemotherapy-induced nausea and vomiting over multiple cycles of moderately or highly emetogenic chemotherapy  Journal Articles
• Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents  Journal Articles
• Exclusion of Patients With Brain Metastases in Published Phase III Clinical Trials for Advanced Breast Cancer  Journal Articles
• External applicability of the COMPASS trial: an analysis of the reduction of atherothrombosis for continued health (REACH) registry  Journal Articles
• Factor Xa inhibition in the prevention of venous thromboembolism and treatment of patients with venous thromboembolism  Journal Articles
• Factors that influence the recruitment of patients to Phase III studies in oncology  Journal Articles
• Fondaparinux  Journal Articles
• Fondaparinux, the first selective factor Xa inhibitor  Journal Articles
• Genome-Wide Associations and Functional Genomic Studies of Musculoskeletal Adverse Events in Women Receiving Aromatase Inhibitors  Journal Articles
• Genome-wide host methylation profiling of anal and cervical carcinoma  Journal Articles
• Go, no-go decision making for phase 3 clinical trials: ACT IV revisited – Authors' reply  Journal Articles
• Identification of a Novel Hepatitis C Virus Genotype From Punjab, India: Expanding Classification of Hepatitis C Virus Into 8 Genotypes  Journal Articles
• Identification of prognostic factors in childhood T‐cell acute lymphoblastic leukemia: Results from DFCI ALL Consortium Protocols 05‐001 and 11‐001  Journal Articles
• Impact of CYP19A1 and ESR1 variants on early-onset side effects during combined endocrine therapy in the TEXT trial  Journal Articles
• Impact of single-agent daily prednisone on outcomes in men with metastatic castration-resistant prostate cancer  Journal Articles
• Implementation of Timeline Reforms Speeds Initiation of National Cancer Institute-Sponsored Trials  Journal Articles
• Implications of variability in definition and reporting of major bleeding in randomized trials of oral P2Y12 inhibitors for acute coronary syndromes  Journal Articles
• Incidence of delayed venous thromboembolic events in patients undergoing abdominal and pelvic surgery for cancer: a systematic review and meta‐analysis  Journal Articles
• Incorporating edoxaban into the choice of anticoagulants for atrial fibrillation  Journal Articles
• Influence of an independent review committee on assessment of response rate and progression-free survival in phase III clinical trials  Journal Articles
• Influence of model-predicted rivaroxaban exposure and patient characteristics on efficacy and safety outcomes in patients with acute coronary syndrome  Journal Articles
• Integrated safety and efficacy analysis of once-daily fluticasone furoate for the treatment of asthma  Journal Articles
• Intraperitoneal chemotherapy in the first‐line treatment of women with stage III epithelial ovarian cancer  Journal Articles
• Lessening Organ dysfunction with VITamin C (LOVIT): protocol for a randomized controlled trial  Journal Articles
• Magnitude of benefit of the addition of bevacizumab to first-line chemotherapy for metastatic colorectal cancer: meta-analysis of randomized clinical trials  Conferences
• Major Bleeding, Mortality, and Efficacy of Fondaparinux in Venous Thromboembolism Prevention Trials  Journal Articles
• Management of Patients with Acute Coronary Syndromes  Journal Articles
• Mepitel Film and Mepilex Lite for the prophylaxis and treatment of skin toxicities from breast radiation  Journal Articles
• National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group Report  Journal Articles
• New Anticoagulant Drugs  Journal Articles
• New Anticoagulants for Atrial Fibrillation  Journal Articles
• New Anticoagulants for Treatment of Venous Thromboembolism  Journal Articles
• New Antithrombotic Drugs  Journal Articles
• New Antithrombotic Drugs  Journal Articles
• New oral anticoagulant agents – general features and outcomes in subsets of patients  Journal Articles
• Optimizing Survival and the Changing Landscape of Targeted Therapy for Intermediate and Advanced Hepatocellular Carcinoma: A Systematic Review  Journal Articles
• Optimizing the safety of treatment for venous thromboembolism in the era of the direct oral anticoagulants  Journal Articles
• Overstated Conclusions of a Pooled Analysis of Bevacizumab in Colon Cancer  Journal Articles
• Overview of the New Oral Anticoagulants  Journal Articles
• Overview of the clinical results of pentasaccharide in major orthopedic surgery.  Journal Articles
• PSMA PET/CT guided intensification of therapy in patients at risk of advanced prostate cancer (PATRON): a pragmatic phase III randomized controlled trial  Journal Articles
• Panorama From the Oncolytic Virotherapy Summit  Journal Articles
• Pentasaccharide Org31540/SR90107A clinical trials update: Lessons for practice  Journal Articles
• Personalized dosing of nicotine replacement therapy versus standard dosing for the treatment of individuals with tobacco dependence: study protocol for a randomized placebo-controlled trial  Journal Articles
• Phase 3 Trials of Stereotactic Radiosurgery With or Without Whole-Brain Radiation Therapy for 1 to 4 Brain Metastases: Individual Patient Data Meta-Analysis  Journal Articles
• Pointed Progress in Second-Line Advanced Non–Small-Cell Lung Cancer: The Rapidly Evolving Field of Checkpoint Inhibition  Journal Articles
• Posttreatment prognostic nomogram for patients with metastatic urothelial cancer completing first-line cisplatin-based chemotherapy  Journal Articles
• Potential net clinical benefit of population-wide implementation of apixaban and dabigatran among European patients with atrial fibrillation  Journal Articles
• Practical Understanding of Mean Percent Psoriasis Area and Severity Index Reduction for Biologics  Journal Articles
• Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA2 five-stage study, including a workshop  Journal Articles
• Practical management of bleeding in patients receiving non-vitamin K antagonist oral anticoagulants  Journal Articles
• Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism  Journal Articles
• Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial  Journal Articles
• Protocol for a phase III RCT and economic analysis of two exercise delivery methods in men with PC on ADT  Journal Articles
• Proton Pump Inhibitors and Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma  Journal Articles
• Proton pump inhibitors: the beginning of the end or the end of the beginning?  Journal Articles
• Quantitative evaluation of single-arm versus randomized phase II cancer clinical trials  Journal Articles
• Quizartinib for the treatment of acute myeloid leukemia  Journal Articles
• Randomized, controlled clinical trials in sepsis: Has methodological quality improved over time?  Journal Articles
• Rapid normalization of vitamin D deficiency in PICU (VITdALIZE-KIDS): study protocol for a phase III, multicenter randomized controlled trial.  Journal Articles
• Rationale and design of the ATTRACT Study: A multicenter randomized trial to evaluate pharmacomechanical catheter-directed thrombolysis for the prevention of postthrombotic syndrome in patients with proximal deep vein thrombosis  Journal Articles
• Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study  Journal Articles
• Real-world vs. randomized trial outcomes in similar populations of rivaroxaban-treated patients with non-valvular atrial fibrillation in ROCKET AF and XANTUS  Journal Articles
• Refining risk classification in childhood B acute lymphoblastic leukemia: results of DFCI ALL Consortium Protocol 05-001  Journal Articles
• Response of Primary Renal Cell Carcinoma to Systemic Therapy  Journal Articles
• Reversal of Direct Oral Anticoagulants: Current Status and Future Directions  Journal Articles
• Riociguat: A Novel Therapeutic Option for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension  Journal Articles
• Rivaroxaban for the prevention and treatment of venous thromboembolism  Journal Articles
• Rivaroxaban for the prevention of venous thromboembolism after hip or knee arthroplasty  Journal Articles
• Rivaroxaban versus enoxaparin after total knee arthroplasty  Journal Articles
• Rolapitant for the Treatment of Chemotherapy-Induced Nausea and Vomiting: A Review of the Clinical Evidence  Journal Articles
• Role of Bone-Modifying Agents in Metastatic Breast Cancer: An American Society of Clinical Oncology–Cancer Care Ontario Focused Guideline Update  Journal Articles
• Role of new anticoagulants for the prevention of venous thromboembolism after major orthopaedic surgery and in hospitalised acutely ill medical patients  Journal Articles
• Safety Outcomes in Meta-analyses of Phase 2 vs Phase 3 Randomized Trials  Journal Articles
• Seasonal influenza vaccines: Variability of immune responses to B lineage viruses.  Journal Articles
• Second-line or Subsequent Systemic Therapy for Recurrent or Progressive Non-Small Cell Lung Cancer: A Systematic Review and Practice Guideline  Journal Articles
• Second‐line treatment of hepatocellular carcinoma after sorafenib: Characterizing treatments used over the past 10 years and real‐world eligibility for cabozantinib, regorafenib, and ramucirumab  Journal Articles
• Seeking informed consent to cancer clinical trials:  Journal Articles
• Stereotactic ablative radiotherapy for the comprehensive treatment of 1–3 Oligometastatic tumors (SABR-COMET-3): study protocol for a randomized phase III trial  Journal Articles
• Systemic adjuvant therapy for adult patients at high risk for recurrent melanoma: A systematic review  Journal Articles
• Systemic therapy in the curative treatment of head and neck squamous cell cancer: A systematic review  Journal Articles
• TLE3 is not a predictive biomarker for taxane sensitivity in the NCIC CTG MA.21 clinical trial  Journal Articles
• Targeting Angiogenesis With Integrative Cancer Therapies  Journal Articles
• Taxanes as first-line therapy for advanced non-small cell lung cancer: A systematic review and practice guideline  Journal Articles
• The Advisory Committee on Immunization Practices’ Interim Recommendation for Use of Moderna COVID-19 Vaccine — United States, December 2020  Journal Articles
• The Diaphragmatic Initiated Ventilatory Assist (DIVA) trial: study protocol for a randomized controlled trial comparing rates of extubation failure in extremely premature infants undergoing extubation to non-invasive neurally adjusted ventilatory assist versus non-synchronized nasal intermittent positive pressure ventilation  Journal Articles
• The Importance of Reporting Patient Recruitment Details in Phase III Trials  Journal Articles
• The SYGMA programme of phase 3 trials to evaluate the efficacy and safety of budesonide/formoterol given ‘as needed’ in mild asthma: study protocols for two randomised controlled trials  Journal Articles
• The association between radiographic response and overall survival in men with metastatic castration‐resistant prostate cancer receiving chemotherapy  Journal Articles
• The effects of rivaroxaban on the complications of surgery after total hip or knee replacement  Journal Articles
• The role of early-phase trials and real-world evidence in drug development  Journal Articles
• The unclear zone in phase II clinical trials  Journal Articles
• Therapy for relapsed multiple myeloma  Journal Articles
• Thromboembolic events, recurrent bleeding and mortality after resuming anticoagulant following gastrointestinal bleeding  Journal Articles
• Thrombopoietin Receptor Agonists in Primary Immune Thrombocytopenia  Journal Articles
• Treatment Success in Cancer: Industry Compared to Publicly Sponsored Randomized Controlled Trials  Journal Articles
• Treatment of idiopathic pulmonary fibrosis: an update on emerging drugs in phase II & III clinical trials  Journal Articles
• Treatment-Dose LMWH versus Prophylactic/Intermediate Dose Heparins in High-Risk COVID-19 Inpatients: Rationale and Design of the HEP-COVID Trial  Journal Articles
• Trends in the application of dynamic allocation methods in multi-arm cancer clinical trials  Journal Articles
• Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update  Journal Articles
• Users’ guide to the surgical literature: how to assess an article using surrogate end points  Journal Articles
• Validation of the Association of RECIST Changes With Survival in Men With Metastatic Castration-Resistant Prostate Cancer Treated on SWOG Study S0421  Journal Articles
• Venous thromboembolism prophylaxis: role of factor xa inhibition by fondaparinux.  Journal Articles
• What's New in Stroke? Phase III Randomized Clinical Trials of 2012–2014  Journal Articles
• When is it safe to stop for safety?  Journal Articles
• Workshop on Partial Breast Irradiation: State of the Art and the Science, Bethesda, MD, December 8-10, 2002  Journal Articles