Major Bleeding, Mortality, and Efficacy of Fondaparinux in Venous Thromboembolism Prevention Trials

BACKGROUND: Bleeding is a strong predictor of death in patients hospitalized for arterial thrombosis who are treated with antithrombotic therapy, but the prognostic importance of bleeding in patients receiving antithrombotic prophylaxis for venous thromboembolism is uncertain. METHODS AND RESULTS: Using Cox proportional hazards modeling, we examined the association between major bleeding and death at 30 days using pooled individual patient data …