Journal article
Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA2 five-stage study, including a workshop
Abstract
BACKGROUND: The randomised controlled trial is widely considered to be the gold standard study for comparing the effectiveness of health interventions. Central to its design is a calculation of the number of participants needed (the sample size) for the trial. The sample size is typically calculated by specifying the magnitude of the difference in the primary outcome between the intervention effects for the population of interest. This …
Authors
Cook JA; Julious SA; Sones W; Hampson LV; Hewitt C; Berlin JA; Ashby D; Emsley R; Fergusson DA; Walters SJ
Journal
Health Technology Assessment, Vol. 23, No. 60, pp. 1–88
Publisher
National Institute for Health and Care Research
Publication Date
October 2019
DOI
10.3310/hta23600
ISSN
1366-5278