Diabetes - McMaster Experts

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183-LB: A Randomized Placebo-Controlled Trial of the Effectiveness of Early Metformin in Addition to Usual Care in the Reduction of Gestational Diabetes Mellitus Effects (EMERGE) 2023
1102-P: Identifying Blood Biomarkers for Type 2 Diabetes Subtyping: A Report from the ORIGIN Trial 2022
1263-P: Adolescent Obesity and Incident Type 1 Diabetes in Young Adulthood 2022
162-LB: Cardiovascular Outcomes in People with Type 2 Diabetes and Acute Coronary Syndrome—The ELIXA Biomarker Study 2022
725-P: Protein Biomarkers Associated with Dulaglutide and Cardiovascular Events in REWIND 2022
731-P: Metabolite Biomarkers and Cardiovascular Events in REWIND: A Post Hoc Analysis 2022
187-OR: Advanced Glycation End Products Predict Loss of Renal Function and High-Risk Chronic Kidney Disease in Type 2 Diabetes in the ACCORD Trial 2021
677-P: Remission of Type 2 Diabetes following Intensive Treatment with Insulin Glargine, Lixisenatide, Metformin, and Lifestyle Approaches: Results of a Multicenter Randomized Controlled Trial 2021
95-LB: LixilanONE CAN: Randomized Trial Comparing a Daily vs. Weekly Titration Algorithm for Switching from Basal Insulin to iGlarLixi Fixed-Ratio Combination in People with T2DM in Canada 2021
130-OR: Effects of Intensive Risk Factor Management on Cardiovascular Autonomic Neuropathy in Type 2 Diabetes: Findings from the ACCORD Trial 2020
1421-P: The Impact of Blood Pressure on Risk of Death Is Influenced by Prior Cardiovascular Disease in Patients with Type 2 Diabetes and a Recent Coronary Event 2020
356-OR: Effect of Dulaglutide on Kidney Function–Related Outcomes in Type 2 Diabetes: Post Hoc Analysis from the REWIND Trial 2020
75-OR: Dietary Nitrate and Fecal Transplantation Prevent Cardiac Dysfunction and Attenuate Left Ventricular Mitochondrial Reactive Oxygen Species Emission in High-Fat Diet-Fed Mice 2020
924-P: Exploring Potential Mediators of the Cardiovascular Benefit of Dulaglutide in REWIND 2020
944-P: HbA1c Change Is Associated with Retinopathy Outcomes during GLP-1RA CVOT Follow-Up 2020
1506-P: Breast Cancer as a Risk Factor for New Diabetes 2019
1767-P: Inflammatory Triggers of Lipolysis Act through IRE1 in Adipocytes 2019
2017-P: Gut Microbes after Bariatric Surgery in Humans Improve Glucose Control in Mice without Fat Loss 2019
2036-P: Gut Microbes Regulate Insulin Clearance in Mice 2019
240-LB: Angiotensin-Converting Enzyme and Type 2 Diabetes Risk: A Mendelian Randomization Study 2019
254-OR: Novel Biomarkers Predicting Renal Dysfunction in People with Dysglycemia in the ORIGIN Trial 2019
Neighborhood Walkability and Diabetes-Related Complications 2018
Clinical Correlates of Predictors of Hypoglycemia over Four Years in 2,729 People with Type 2 Diabetes Starting Insulin 2017
Genetic Associations with Lipid Metabolites in Pregnancy 2017
Genetic Predictors of Cardiovascular Outcomes during Intensive Blood Pressure Control in ACCORD 2017
Novel Biomarkers Predicting Heart Failure Hospitalization in People with Dysglycemia in the ORIGIN Trial 2017
BNP Enhances Predictive Models of Cardiovascular Outcomes in Patients with Type 2 Diabetes and a Recent Coronary Event 2016
Clinical Performance of One Touch Verio Blood Glucose Monitoring Systems 2016
Genetic Predictors of Cardiovascular Mortality during Intensive Glycemic Control in Type 2 Diabetes 2016
Novel Biomarkers Predicting a Microvascular Composite Outcome in People with Dysglycemia in the ORIGIN Trial 2016
OneTouch Verio Performance at Extremes of Glucose and Hematocrit 2016
Performance of the Validated ORIGIN Cardiovascular Biomarker Panel in HOPE Study Participants with Diabetes 2016
Severe Hypoglycemic Episodes Are Associated with Falls and Fractures in ACCORD 2016
Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolomes Associated with BMI and Glucose during Pregnancy across Four Ancestry Groups 2016
Genetic Signal for Renal Function Decline in Type 1 Diabetes (T1D) Identified by Analysis of Repeated Longitudinal Measures 2015
Predictors of Remission of Type 2 Diabetes following a Short-Term Intensive Metabolic Intervention 2015
Self-Perceived Distress and Diabetes Risk among Young Men 2015
Targeted and Nontargeted Metabolomics Profiling Identifies Metabolic Signatures Unique to Maternal BMI and Glycemia 2015
Association between Diabetes, Prediabetes, and Cardiac Structure and Function among Hispanics: Results from the Echocardiographic Study of Latinos 2014
Clinical and Biochemical Markers of Nonprogression to Type 2 Diabetes Mellitus from a "Prediabetes" Stage 2014
Genetic Variants Associated with Repeated Longitudinal Measures of Renal Function in Type 1 Diabetes (T1D) 2014
Prevalence and Determinants of Peripheral Neuropathy and Nerve Dysfunction in a Population at High Risk for Type 2 Diabetes-The PROMISE Cohort 2014
Association of Differential White Blood Cell Count With Insulin Resistance and beta-Cell Dysfunction-The PROMISE Cohort 2013
Cancer Outcomes in Patients With Dysglycemia on Basal Insulin: Results of the ORIGIN Trial 2013
Cancer Outcomes in Patients With Dysglycemia on Basal Insulin: Results of the ORIGIN Trial 2013
Effect of Basal Insulin Glargine and Omega 3 FA on Cognitive Decline and Dementia in People With Dysglycemia 2013
Handgrip Strength Is Associated With Glomerular Filtration Rate in Patients With Diabetes Type 2 2013
Handgrip Strength Predicts Cardiovascular Mortality: A Subanalysis of the ORIGIN Trial 2013
The Association of Leg Length With Metabolic Abnormalities Underlying Type 2 Diabetes Mellitus: The PROMISE Cohort 2013
Alanine Transaminase and Waist to Hip Ratio Predict Regression to Normoglycemia and AUC(glucose0-120 min) in Adult Patients With Prediabetes 2012
Changes in Adiposity Predict Changes in Serum 25(OH)D Over 3 Years of Follow-up: The PROspective Metabolism and Islet Cell Evaluation (PROMISE) Cohort Study 2012
Diet Oleic Acid (OA) Improves Metabolic Risk Factors in Young Adults: Lipidomic Analysis of Sexually Dimorphic Responsiveness 2012
Evaluating the Feasibility and Impact of an Internet-Based Lifestyle Modification Program in a Clinical Setting 2012
Pharmacological Inhibition of DGAT-1 Improves Insulin Sensitivity and Metabolic Profile 2012
Alanine Aminotransferase and Progression of Insulin Resistance and Beta Cell Dysfunction 2011
Is Insulin Exposure Associated with Higher Risk of Cancer-Related Hospitalization or Death? Analysis of 5-Year Data from the ACCORD Trial 2011
Lack of Inteferon-gamma Results in Reduced Body Weight and Better Glucose Tolerance 2011
Piloting a Novel Algorithm for Glucose Control in the Coronary Care Unit: The RECREATE (REsearching Coronary REduction by Appropriately Targeting Euglycemia) Trial 2011
Prospective Association of Vitamin D with Beta-Cell Function and Glycemia 2011
Diabetes Quality of Care Varies between Ethnic Groups in Ontario, Canada 2010
High-Fat Feeding Alters Muscle Stem Cell Functional Capacity 2010
Impaired Myofiber Regeneration in Type 1 Diabetic Skeletal Muscle 2010
Muscle Stem Cell Activation Is Impaired with Type I Diabetes Mellitus 2010
Validation of the DM Reporter Text Mining Application for Evaluating the Management of High Risk Populations with Diabetes 2010
A Genome-Wide Association Study Identifies Variation near SORCS1 as a Major Locus for Glycemic Control in Type 1 Diabetes, as Measured by Both HbA1c and Glucose 2009
Association of Hematological Parameters with Insulin Sensitivity and beta-Cell Dysfunction in Non-Diabetic Subjects 2009
Cardiac Autonomic Dysfunction Prodicts Cardiovascular Mortality in the Action To Control Cardiovascular Risk in Diabetes (ACCORD) Trial 2009
Effect of Rosiglitazone and Ramipril on beta-Cell Function in Subjects with Impaired Glucose Tolerance (IGT) or Impaired Fasting Glucose (IFG): The DREAM Trial 2009
Genome Wide Association Analysis Identifies Genetic Risk Factors for Coronary-Calcium in Subjects with Type 1 Diabetes in the DCCT/EDIC Genetics Study 2009
Impact of Ramipril on Body Fat Compartments and Hepatic Fat in the DREAM Trial 2009
Impact of Rosiglitazone on Body Fat Compartments and Hepatic Fat in the DREAM Trial 2009
The Relationship between Dysglycemia Category and Cognitive Function: The ORIGIN Cognitive Sub-Study 2009
An oral glucose challenge induces endoplasmic reticulum stress in circulating blood cells and vascular tissue: A possible mechanism linking postprandial hyperglycemia to cardiovascular risk 2008
Diabetes management in Canada: Evidence of an ongoing care gap 2008
Echocardiographic epicardial fat predicts the metabolic syndrome 2008
Enhanced cellular uptake of remnant HDL particles: A mechanism for HDL lowering in insulin resistance and hypertriglyceridemia 2008
Frailty grip is associated with glucose intolerance: Results from the epidemiological DREAM study population 2008
Inherited increases in glycolytic flux and decreased TCA cycle activity underlies enhanced oxidative capacity, improved metabolic status and longevity in rats 2008
Management of vascular risk factors in a cohort of patients with type 2 diabetes mellitus (DM) in Canada: Significant gap between guidelines recommendations and current practice 2008
Patient-important outcomes in diabetes trials: Novel use of trial registries to forecast the future 2008
The relationship between baseline HbA1c levels and cognitive function in people with type 2 diabetes and other cardiovascular risk factors: The ACCORD-MIND study 2008
Whole 24-hour continuous glucose monitoring (CGM) profiles with insulin glargine or oral antidiabetic drug (OAD) therapy in patients with type 2 diabetes mellitus (T2DM) 2008
Increased serum EDB fibronectin in proliferative diabetic retinopathy 2007
Novel activators of AMP-Kinase as potential therapies for type 2 diabetes 2007
Perioperative insulin infusion: A systematic review and meta-analysis of randomized controlled trials 2007
The effect of rosiglitazone on peripheral insulin signaling and glucose utilization pathways following fetal and neonatal exposure to nicotine in rats 2007
A systematic review and meta-analysis of hypoglycemia and cardiovascular events: A comparison of glyburide with other secretagogues and with insulin 2006
Clinical outcomes associated with the use of subcutaneous insulin-by-glucose sliding scales to manage hyperglycemia in hospitalized patients with pneumonia 2006
Design and acceptability of a decision aid about statin use for patients with type 2 diabetes.: Statin choice 2006
Interferon-gamma deficient mice become obese and have impaired glucose homeostasis when exposed to moderate levels of dietary fat 2006
A Randomized trial of early glargine use to achieve optimal Alc levels in insulin naive people with type 2 diabetes 2005
Cognitive decline in diabetes - A systematic overview and meta-analysis of observational studies 2005
Does progression to ADA-defined diabetes predict hypertension in middle-aged and older adults? Rvidence from the western New York study 2005
Skeletal muscle HSL activity in response to epinephrine and exercise training in obese and lean individuals 2005
Design and baseline characteristics of the DREAM (diabetes REduction assessment with ramipril and rosiglitazone medication) trial 2004
Glucose & incident CVD in diabetic & nondiabetic patients on dialysis: Data from the GARRD study 2004
Supression of GLUT2 and glucokinase expression in insulinoma cells and islets of langerhans by adenovirus-mediated RNA interference 2004
Glucosamine-induced endoplasmic reticulum (ER) stress promotes cellular dysfunction associated with atherogenesis 2003
Neuropsychological and neuro imaging evidence of hippocampal damage in Type I diabetes: A pilot investigation. 2003
Audit of the implimentation of a cardiovascular risk factor reduction strategy in patients with type II diabetes 2002
Meal-based repaglinide therapy in type 2 diabetes can be titrated using either preprandial or postprandial blood glucose to maximize glycemic control 2001
Stress hyperglycemia and prognosis of myocardial infarction in nondiabetic and diabetic patients: a systematic overview 1999
Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview 1999
A one day continuing medical education workshop improves primary care physicians' attitude, knowledge and self-reported practice patterns regarding diabetes. 1997
Hydroxychloroquine improves glycemic control in NIDDM. 1997
MICROALBUMINURIA AND MORTALITY IN NIDDM - A SYSTEMATIC OVERVIEW OF THE LITERATURE 1995
EFFECTS OF ALPRAZOLAM ON ANXIETY AND GLUCOSE CONTROL IN DIABETES - RESULTS OF A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL 1994
The miR-203/ZBTB20/MAFA Axis Orchestrates Pancreatic β-Cell Maturation and Identity During Weaning and Diabetes.. 73:1673-1686. 2024
1870-LB: Evaluating Remission of Type 2 Diabetes Using a Metabolic Intervention Including Fixed-Ratio Insulin Degludec and Liraglutide—A Randomized Controlled Trial. 73. 2024
Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis. 73:51-56. 2024
β-Cell miRNA-503-5p Induced by Hypomethylation and Inflammation Promotes Insulin Resistance and β-Cell Decompensation. 73:57-74. 2024
Erratum. Association Between Obesity and Chronic Kidney Disease: Multivariable Mendelian Randomization Analysis and Observational Data From a Bariatric Surgery Cohort. Diabetes 2023;72:496–510. 72:1174-1174. 2023
Dietary Nitrate and Corresponding Gut Microbiota Prevent Cardiac Dysfunction in Obese Mice. 72:844-856. 2023
123-OR: SGLT2 Inhibitors Are Associated with Kidney Benefits at All Degrees of Proteinuria—A Cohort Study. 72. 2023
221-LB: Identification of PAM as Novel Monogenic Diabetes Gene. 72. 2023
Association Between Obesity and Chronic Kidney Disease: Multivariable Mendelian Randomization Analysis and Observational Data From a Bariatric Surgery Cohort. 72:496-510. 2023
Glucose Intolerance in Pregnancy and Offspring Obesity in Late Adolescence. 45:1540-1548. 2022
1276-P: Transancestral Genomic Analysis Links Dysregulation of Valine Metabolism to the Development of Heart Failure in Type 2 Diabetes. 71. 2022
190-LB: Vaspin—A Novel Predictor of Type 2 Diabetes Risk. 71. 2022
200-OR: IER3IP1 Is Critical for Maintaining Glucose Homeostasis through Regulating the Endoplasmic Reticulum Function and Survival of ß-Cells. 71. 2022
Impaired Cold-Stimulated Supraclavicular Brown Adipose Tissue Activity in Young Boys With Obesity. 71:1193-1204. 2022
916-P: Precision Evaluation of Clinical Laboratory Glucose Reference Systems. 69. 2020
PPARA Polymorphism Influences the Cardiovascular Benefit of Fenofibrate in Type 2 Diabetes: Findings From ACCORD-Lipid. 69:771-783. 2020
Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes. 69:784-795. 2020
Statins Promote Interleukin-1β–Dependent Adipocyte Insulin Resistance Through Lower Prenylation, Not Cholesterol. 68:1441-1448. 2019
Diagnostic Accuracy of Serologic Screening Tests for Celiac Disease in Asymptomatic Adults and Children with Type 1 Diabetes. 67. 2018
Frequency, Severity, and Associations of Gastrointestinal Symptoms in Adults and Children with Type 1 Diabetes. 67. 2018
Higher Rates of Celiac Disease Serology and Biopsy Positivity in Adults with Type 1 Diabetes. 67. 2018
Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes. 67:1310-1321. 2018
Cellular Energy Sensing and Metabolism—Implications for Treating Diabetes: The 2017 Outstanding Scientific Achievement Award Lecture. 67:169-179. 2018
Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise. 66:1548-1559. 2017
Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome. 66:418-425. 2017
Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1. 65:3352-3361. 2016
Decreased Satellite Cell Number and Function in Humans and Mice With Type 1 Diabetes Is the Result of Altered Notch Signaling. 65:3053-3061. 2016
The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels. 65:2784-2794. 2016
New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated Proteins. 65:2060-2071. 2016
Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling. 64:2769-2779. 2015
GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R. 64:2537-2549. 2015
Inhibition of PAI-1 Via PAI-039 Improves Dermal Wound Closure in Diabetes. 64:2593-2602. 2015
Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance. 63:3742-3747. 2014
Genetic Dissection of Diabetes: Facing the Giant. 62:3338-3340. 2013
Transient B-Cell Depletion Combined With Apoptotic Donor Splenocytes Induces Xeno-Specific T- and B-Cell Tolerance to Islet Xenografts. 62:3143-3150. 2013
Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity. 62:56-64. 2013
Loss of TDAG51 Results in Mature-Onset Obesity, Hepatic Steatosis, and Insulin Resistance by Regulating Lipogenesis. 62:158-169. 2013
Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity. 61:383-390. 2012
Prospective Associations of Vitamin D With β-Cell Function and Glycemia. 60:2947-2953. 2011
NOD1 Activators Link Innate Immunity to Insulin Resistance. 60:2206-2215. 2011
Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance. 60:2023-2031. 2011
Inhibition of Plasminogen Activator Inhibitor-1 Restores Skeletal Muscle Regeneration in Untreated Type 1 Diabetic Mice. 60:1964-1972. 2011
Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling. 60:1414-1423. 2011
SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol. 59:551-553. 2010
A Genome-Wide Association Study Identifies a Novel Major Locus for Glycemic Control in Type 1 Diabetes, as Measured by Both A1C and Glucose. 59:539-549. 2010
Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase–Dependent Pathway That Is Impaired With Obesity. 58:829-839. 2009
RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease. 57:1683-1692. 2008
AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5. 57:860-867. 2008
The Idd4 Locus Displays Sex-Specific Epistatic Effects on Type 1 Diabetes Susceptibility in Nonobese Diabetic Mice. 55:3611-3619. 2006
PDH-E1α Dephosphorylation and Activation in Human Skeletal Muscle During Exercise. 55:3020-3027. 2006
Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase. 55:2688-2697. 2006
Glucosamine-Induced Endoplasmic Reticulum Dysfunction Is Associated With Accelerated Atherosclerosis in a Hyperglycemic Mouse Model. 55:93-101. 2006
Altered Calcium Homeostasis Is Correlated With Abnormalities of Fasting Serum Glucose, Insulin Resistance, and β-Cell Function in the Newfoundland Population. 54:3336-3339. 2005
Homocysteine Metabolism in ZDF (Type 2) Diabetic Rats. 54:3245-3251. 2005
The Stimulatory Effect of Globular Adiponectin on Insulin-Stimulated Glucose Uptake and Fatty Acid Oxidation Is Impaired in Skeletal Muscle From Obese Subjects. 54:3154-3160. 2005
Flux Through the Hexosamine Pathway Is a Determinant of Nuclear Factor κB– Dependent Promoter Activation. 51:1146-1156. 2002
Decreased In Situ Insulin Receptor Dephosphorylation in Hyperglycemia-Induced Insulin Resistance in Rat Adipocytes. 50:83-90. 2001
Beta-blockade, but not normoglycemia or hyperinsulinemia, markedly diminishes stress-induced hyperglycemia in diabetic dogs.. 49:253-262. 2000
Opposite effects of acute hypoglycemia and acute hyperglycemia on glucose transport and glucose transporters in perfused rat skeletal muscle.. 48:1281-1288. 1999
Stimulation of Glucose Uptake by the Natural Coenzyme α-Lipoic Acid/Thioctic Acid: Participation of Elements of the Insulin Signaling Pathway. 45:1798-1804. 1996
The Insulin-Mimetic Agent Vanadate Promotes Receptor Endocytosis and Inhibits Intracellular Ligand-Receptor Degradation by a Mechanism Distinct From the Lysosomotropic Agents. 45:1084-1093. 1996
The insulin-mimetic agent vanadate promotes receptor endocytosis and inhibits intracellular ligand-receptor degradation by a mechanism distinct from the lysosomotropic agents. 45:1084-1093. 1996
MHC Class I-Mediated Antigen Presentation and Induction of CD8+ Cytotoxic T-Cell Responses in Autoimmune Diabetes-Prone NOD Mice. 45:902-908. 1996
Reduced Membrane Fluidity in Platelets From Diabetic Patients. 39:241-244. 1990
Reduced membrane fluidity in platelets from diabetic patients. 39:241-244. 1990
Regulation of Glycogenolysis and Pyruvate Oxidation in Human Skeletal Muscle In Vivo. 28:100-102. 1979

Diabetes Journal

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