Journal article
Homocysteine Metabolism in ZDF (Type 2) Diabetic Rats
Abstract
Mild hyperhomocysteinemia is a risk factor for many diseases, including cardiovascular disease. We determined the effects of insulin resistance and of type 2 diabetes on homocysteine (Hcy) metabolism using Zucker diabetic fatty rats (ZDF/Gmi fa/fa and ZDF/Gmi fa/?). Plasma total Hcy was reduced in ZDF fa/fa rats by 24% in the pre-diabetic insulin-resistant stage, while in the frank diabetic stage there was a 59% reduction. Hepatic activities of …
Authors
Wijekoon EP; Hall B; Ratnam S; Brosnan ME; Zeisel SH; Brosnan JT
Journal
Diabetes, Vol. 54, No. 11, pp. 3245–3251
Publisher
American Diabetes Association
Publication Date
November 1, 2005
DOI
10.2337/diabetes.54.11.3245
ISSN
0012-1797