Journal article
PDH-E1α Dephosphorylation and Activation in Human Skeletal Muscle During Exercise Effect of Intralipid Infusion
Abstract
To investigate pyruvate dehydrogenase (PDH)-E1alpha subunit phosphorylation and whether free fatty acids (FFAs) regulate PDH activity, seven subjects completed two trials: saline (control) and intralipid/heparin (intralipid). Each infusion trial consisted of a 4-h rest followed by a 3-h two-legged knee extensor exercise at moderate intensity. During the 4-h resting period, activity of PDH in the active form (PDHa) did not change in either …
Authors
Pilegaard H; Birk JB; Sacchetti M; Mourtzakis M; Hardie DG; Stewart G; Neufer PD; Saltin B; van Hall G; Wojtaszewski JFP
Journal
Diabetes, Vol. 55, No. 11, pp. 3020–3027
Publisher
American Diabetes Association
Publication Date
November 1, 2006
DOI
10.2337/db06-0152
ISSN
0012-1797