Journal article
The Idd4 Locus Displays Sex-Specific Epistatic Effects on Type 1 Diabetes Susceptibility in Nonobese Diabetic Mice
Abstract
The nonobese diabetic (NOD) mouse recapitulates many aspects of the pathogenesis of type 1 diabetes in humans, including inheritance as a complex trait. More than 20 Idd loci have been linked to type 1 diabetes susceptibility in NOD mice. Previously, we used linkage analysis of NOD crossed to the nonobese diabetes-resistant (NOR) strain and NOD congenic strains to map susceptibility to both spontaneous and cyclophosphamide-accelerated type 1 …
Authors
Ivakine EA; Mortin-Toth SM; Gulban OM; Valova A; Canty A; Scott C; Danska JS
Journal
Diabetes, Vol. 55, No. 12, pp. 3611–3619
Publisher
American Diabetes Association
Publication Date
December 1, 2006
DOI
10.2337/db06-0758
ISSN
0012-1797