Journal article
A Genome-Wide Association Study Identifies a Novel Major Locus for Glycemic Control in Type 1 Diabetes, as Measured by Both A1C and Glucose
Abstract
OBJECTIVE: Glycemia is a major risk factor for the development of long-term complications in type 1 diabetes; however, no specific genetic loci have been identified for glycemic control in individuals with type 1 diabetes. To identify such loci in type 1 diabetes, we analyzed longitudinal repeated measures of A1C from the Diabetes Control and Complications Trial.
RESEARCH DESIGN AND METHODS: We performed a genome-wide association study using …
Authors
Paterson AD; Waggott D; Boright AP; Hosseini SM; Shen E; Sylvestre M-P; Wong I; Bharaj B; Cleary PA; Lachin JM
Journal
Diabetes, Vol. 59, No. 2, pp. 539–549
Publisher
American Diabetes Association
Publication Date
February 1, 2010
DOI
10.2337/db09-0653
ISSN
0012-1797
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Blood GlucoseC-PeptideDiabetes ComplicationsDiabetes Mellitus, Type 1Drug Administration ScheduleEthnicityGenome-Wide Association StudyGlycated HemoglobinHumansHyperglycemiaHypoglycemic AgentsInsulinMeta-Analysis as TopicPatient SelectionPolymorphism, Single NucleotideRacial GroupsReceptors, Cell SurfaceReference ValuesSiblings