Journal article
1276-P: Transancestral Genomic Analysis Links Dysregulation of Valine Metabolism to the Development of Heart Failure in Type 2 Diabetes
Abstract
Persons with type 2 diabetes (T2D) remain at increased risk of heart failure (HF) despite control of known cardiovascular risk factors. The aim of this study was to identify genes and molecular pathways specifically linking T2D to HF. To this end, we conducted a trans-ancestral genome-wide association study (GWAS) using data from ACCORD, ORIGIN, and six TOPMed cohorts (ARIC, CHS, FHS, JHS, MESA, WHI) . Included were a total of 19,8 participants …
Authors
TANG Y; PIGEYRE M; SUN X; MORIERI ML; SHAH H; PARE G; GERSTEIN HC; TAYLOR K; RAMACHANDRAN VS; ROTTER JI
Journal
Diabetes, Vol. 71, No. Supplement_1,
Publisher
American Diabetes Association
Publication Date
June 1, 2022
DOI
10.2337/db22-1276-p
ISSN
0012-1797