Conference
240-LB: Angiotensin-Converting Enzyme and Type 2 Diabetes Risk: A Mendelian Randomization Study
Abstract
The causal relationship between angiotensin-converting enzyme (ACE) inhibition and protection from type 2 diabetes (T2D) remains uncertain. While three large randomized control trials (RCTs) suggested a protective effect of ACE inhibitors compared to placebo, three other RCTs failed to observe an effect, including the only trial dedicated to this question. We hypothesized that ACE concentration-lowering genetic variants could be used to infer …
Authors
PIGEYRE M; SJAARDA J; CHONG M; HESS S; BOSCH J; YUSUF S; GERSTEIN H; PARE G
Volume
68
Publisher
American Diabetes Association
Publication Date
June 1, 2019
DOI
10.2337/db19-240-lb
Conference proceedings
Diabetes
Issue
Supplement_1
ISSN
0012-1797