183-LB: A Randomized Placebo-Controlled Trial of the Effectiveness of Early Metformin in Addition to Usual Care in the Reduction of Gestational Diabetes Mellitus Effects (EMERGE)

The optimal approach to managing GDM is uncertain. We sought to determine whether early introduction of metformin (at diagnosis) plus lifestyle modification was superior to standard care (lifestyle modification alone). Methods: EMERGE is a phase III, superiority, parallel-group, 1:1 randomized trial comparing effectiveness of early metformin vs placebo initiated before 28 weeks +6 days. GDM was confirmed using WHO 2013 …