Kathryn Grandfield - McMaster Experts

Affiliations

McMaster University,
Member, McMaster Institute for Research on Aging (MIRA), McMaster University
Member, Canadian Centre for Electron Microscopy, McMaster University
Associate Member, Biomedical Engineering, Faculty of Engineering
Associate Professor, Materials Science and Engineering, Faculty of Engineering
Member, Biointerfaces Institute, Faculty of Science

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selected scholarly activity

chapters
- Advanced Analyses for Characterizing Bone Repair and Osseointegration. 343-354. 2017
- 9 Laser surface modification and the tissue–implant interface. 253-280. 2016
- Laser surface modification and the tissue–implant interface. 253-280. 2016
conferences
- New processing and applications of cross-linked cellulose nanocrystal aerogels: Bone implants, delivery systems, and components for energy storage and production devices. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2019
- New Applications of crosslinked cellulose nanocrystal aerogels: Sorbents, bone implants and energy production & storage devices. International Conference on Nanotechnology for Renewable Materials 2019. 167-176. 2019
- New production strategies for tissue scaffolds containing cellulose nanocrystals and their fate in vivo. International Conference on Nanotechnology for Renewable Materials 2018. 229-238. 2018
- On the mechanism of using carbon dioxide as a beneficial concrete admixture. American Concrete Institute, ACI Special Publication. 415-427. 2018
- Cross-linked cellulose aerogels for bone scaffolding applications. International Conference on Nanotechnology for Renewable Materials 2017. 628-647. 2017
- Gold nanoparticles facilitate a "bright future" for collagen scaffolds in regenerative medicine. IPMI's 41st Annual International Conference. 390-395. 2017
- Microscopic characterization to study the mechanism of beneficial CO2 utilization in ready mixed concrete production. 39th International Conference on Cement Microscopy, ICMA 2017. 183-197. 2017
- In Situ Study of ALD Processes Using Synchrotron-based X-ray Fluorescence and Scattering Techniques. ECS Transactions. 35-42. 2013
- Electron tomography: A tool for the study of nano-osseointegration in 3D. European Cells and Materials. 39. 2011
journal articles
- Characterization of human trabecular bone across multiple length scales using a correlative approach combining X-ray tomography with LaserFIB and plasma FIB-SEM.. Scientific Reports. 14:21604. 2024
- Mesoscale characterization of osseointegration around an additively manufactured genistein-coated implant. Scientific Reports. 14:15339. 2024
- New Avenues for Capturing Mineralization Events at Biomaterial Interfaces with Liquid-Transmission Electron Microscopy. Nano Letters. 24:7821-7824. 2024
- An effective strategy to inhibit grain coarsening: Construction of multi-element co-segregated grain boundary complexion. Journal of Advanced Ceramics. 13:1060-1071. 2024
- Tooth acellular extrinsic fibre cementum incremental lines in humans are formed by parallel branched Sharpey’s fibres and not by its mineral phase. Journal of Structural Biology. 216:108084-108084. 2024
- Effect of plate orientation on apparent thickness of mineral plates by transmission electron microscopy. Journal of Bone and Mineral Metabolism. 42:344-351. 2024
- Impact of palladium/palladium hydride conversion on electrochemical CO2 reduction via in-situ transmission electron microscopy and diffraction. Nature Communications. 15:938. 2024
- Ultrastructure and Nanoporosity of Human Bone Shown with Correlative On-Axis Electron and Spectroscopic Tomographies. ACS Nano. 17:24710-24724. 2023
- Nanoscale implant anchorage aided by cement line deposition into titanium dioxide nanotubes. Journal of Biomedical Materials Research - Part A. 111:1866-1874. 2023
- Osseointegration of functionally graded Ti6Al4V porous implants: Histology of the pore network. Biomaterials Advances. 155:213697-213697. 2023
- Liquid Transmission Electron Microscopy for Probing Collagen Biomineralization. Nano Letters. 23:9760-9768. 2023
- Characterizing Mineral Ellipsoids in New Bone Formation at the Interface of Ti6Al4V Porous Implants. Advanced Materials Interfaces. 10. 2023
- Characterizing Mineral Ellipsoids in New Bone Formation at the Interface of Ti6Al4V Porous Implants (Adv. Mater. Interfaces 24/2023). Advanced Materials Interfaces. 10. 2023
- Liquid Transmission Electron Microscopy Imaging of Organic-inorganic Interfaces: Exploring Hydrated Collagen Mineralization Processes. Microscopy and Microanalysis. 29:1236-1238. 2023
- Bone structure and composition in a hyperglycemic, obese, and leptin receptor-deficient rat: Microscale characterization of femur and calvarium. Bone. 172:116747-116747. 2023
- Functionalization of 3D Printed Scaffolds Using Polydopamine and Silver Nanoparticles for Bone-Interfacing Applications. ACS Applied Bio Materials. 6:1161-1172. 2023
- Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats. Biology. 12:228-228. 2023
- Characterizing Mineral Ellipsoids in New Bone Formation at the Interface of Ti6Al4V Porous Implants 2023
- Unraveling the Supramolecular Structure and Nanoscale Dislocations of Bacterial Cellulose Ribbons Using Correlative Super-Resolution Light and Electron Microscopy. Biomacromolecules. 24:258-268. 2023
- Multimodal and Multiscale Characterization of the Bone‐Bacteria Interface in a Case of Medication‐Related Osteonecrosis of the Jaw. JBMR Plus. 6:e10693. 2022
- Fabrication of succinate-alginate xerogel films for in vitro coupling of osteogenesis and neovascularization. Biomaterials Advances. 141:213122-213122. 2022
- Atom probe tomography for biomaterials and biomineralization. Acta Biomaterialia. 148:44-60. 2022
- Exploring Calcium Phosphate Biomineralization Systems Using In Situ Liquid Phase Electron Microscopy. Microscopy and Microanalysis. 28:1818-1820. 2022
- Visualizing Early HCoV-229E Viral Infection Events Using Correlative 2D Light and 3D Electron Microscopy Techniques. Microscopy and Microanalysis. 28:1528-1530. 2022
- Utilization of FIB–SEM nanotomography to visualize early HCoV-229E virus-mediated endocytosis nanoscale interactions. Acta Crystallographica Section A: Foundations of Crystallography. 78:a319-a319. 2022
- Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice. Journal of Visualized Experiments. 2022. 2022
- Impact of Leptin Receptor (LepR) Gene Deficiency and Type 2 Diabetes Mellitus on Endochondral and Intramembranous Ossification in a Rat Model. Bone Reports. 16:101430-101430. 2022
- Bone mineral organization at the mesoscale: A review of mineral ellipsoids in bone and at bone interfaces. Acta Biomaterialia. 142:1-13. 2022
- PTH 1-34-functionalized bioactive glass improves peri-implant bone repair in orchiectomized rats: Microscale and ultrastructural evaluation. Biomaterials Advances. 134:112688-112688. 2022
- Ionic liquid treatment for efficient sample preparation of hydrated bone for scanning electron microscopy. Micron. 153:103192-103192. 2022
- Resonance vibration interventions in the femur: Experimental-numerical modelling approaches. Journal of the Mechanical Behavior of Biomedical Materials. 124:104850-104850. 2021
- From tissue retrieval to electron tomography: nanoscale characterization of the interface between bone and bioactive glass. Journal of the Royal Society Interface. 18:20210181-20210181. 2021
- Visualization of Collagen–Mineral Arrangement Using Atom Probe Tomography. Advanced Biology. 5:e2100657. 2021
- Three-Dimensional Insights into Interfacial Segregation at the Atomic Scale in a Nanocrystalline Glass-Ceramic. Nano Letters. 21:6898-6906. 2021
- Electron Microscopy Imaging Applications of Room Temperature Ionic Liquids in the Biological Field: A Review. ChemBioChem. 22:2488-2506. 2021
- Correlative Light and Electron Microscopy for the Study of the Structural Arrangement of Bacterial Microcrystalline Cellulose Microfibrils. Microscopy and Microanalysis. 27:566-569. 2021
- Current interpretations on the in vivo response of bone to additively manufactured metallic porous scaffolds: A review. Biomater Biosyst. 2:100013-100013. 2021
- Implant resonance and the mechanostat theory: Applications of therapeutic ultrasound for porous metallic scaffolds. Materials Science and Engineering C. 125:112070-112070. 2021
- Selective Voronoi tessellation as a method to design anisotropic and biomimetic implants. Journal of the Mechanical Behavior of Biomedical Materials. 116:104361-104361. 2021
- Drug release from polymer-coated TiO₂ nanotubes on additively manufactured Ti-6Al-4V bone implants: a feasibility study. Nano Express. 2:010018-010018. 2021
- Simultaneous Visualization of Wet Cells and Nanostructured Biomaterials in SEM using Ionic Liquids. ChemBioChem. 22:571-576. 2021
- Ellipsoidal mesoscale mineralization pattern in human cortical bone revealed in 3D by plasma focused ion beam serial sectioning. Journal of Structural Biology. 212:107615-107615. 2020
- The impacts of in-situ carbonate seeding on the early hydration of tricalcium silicate. Cement and Concrete Research. 136:106179-106179. 2020
- Composite dip coating improves biocompatibility of porous metallic scaffolds. Materials Letters. 274:128057-128057. 2020
- Teriparatide improves microarchitectural characteristics of peri-implant bone in orchiectomized rats. Osteoporosis International. 31:1807-1815. 2020
- Electrochemical Fabrication and Characterization of Pectin Hydrogel Composite Materials for Bone Tissue Repair. ACS Applied Polymer Materials. 2:3390-3396. 2020
- A Facile Method for Simultaneous Visualization of Wet Cells and Nanostructured Biomaterials in SEM using Ionic Liquids 2020
- Visualization of Collagen–Mineral Arrangement using Atom Probe Tomography 2020
- Human bone mesoscale 3D structure revisited by plasma focused ion beam serial sectioning 2020
- A search for apatite crystals in the gap zone of collagen fibrils in bone using dark-field illumination. Bone. 135:115304-115304. 2020
- Response of Saos-2 osteoblast-like cells to kilohertz-resonance excitation in porous metallic scaffolds. Journal of the Mechanical Behavior of Biomedical Materials. 106:103726-103726. 2020
- Electrophoretic deposition of polymethylmethacrylate and composites for biomedical applications. Colloids and Surfaces B: Biointerfaces. 188:110763-110763. 2020
- Ti–5Al–5Mo–5V–3Cr bone implants with dual-scale topography: a promising alternative to Ti–6Al–4V. Nanotechnology. 31:235101-235101. 2020
- Flexible Hierarchical Wraps Repel Drug-Resistant Gram-Negative and Positive Bacteria. ACS Nano. 14:454-465. 2020
- A Bioprinted In Vitro Model for Osteoblast to Osteocyte Transformation by Changing Mechanical Properties of the ECM. Advanced Biology. 3:e1900126. 2019
- Biomedical Applications: A Bioprinted In Vitro Model for Osteoblast to Osteocyte Transformation by Changing Mechanical Properties of the ECM (Adv. Biosys. 10/2019). Advanced Biology. 3. 2019
- Niobium pentoxide and hydroxyapatite particle loaded electrospun polycaprolactone/gelatin membranes for bone tissue engineering. Colloids and Surfaces B: Biointerfaces. 182:110386-110386. 2019
- Identification of collagen fibrils in cross sections of bone by electron energy loss spectroscopy (EELS). Micron. 124:102706-102706. 2019
- Fabrication of polycaprolactone electrospun nanofibers doped with silver nanoparticles formed by air plasma treatment. Nanotechnology. 30:215101-215101. 2019
- Biomimetic modification of poly-l-lysine and electrodeposition of nanocomposite coatings for orthopaedic applications. Colloids and Surfaces B: Biointerfaces. 176:115-121. 2019
- Nondestructive, longitudinal measurement of collagen scaffold degradation using computed tomography and gold nanoparticles. Nanoscale. 11:4345-4354. 2019
- Correlative Spectromicroscopy and Tomography for Biomedical Applications Involving Electron, Ion, and Soft X-ray Microscopies. Microscopy Today. 27:12-19. 2019
- Cross-linked cellulose nanocrystal aerogels as viable bone tissue scaffolds. Acta Biomaterialia. 87:152-165. 2019
- Ultrastructure of Bone: Hierarchical Features from Nanometer to Micrometer Scale Revealed in Focused Ion Beam Sections in the TEM. Calcified Tissue International. 103:606-616. 2018
- Biomineralization of calcium phosphate revealed by in situ liquid-phase electron microscopy. Communications Chemistry. 1. 2018
- Advances in Multiscale Characterization Techniques of Bone and Biomaterials Interfaces. ACS Biomaterial Science and Engineering. 4:3678-3690. 2018
- Correlative Spectromicroscopy and Tomography Involving Soft X-ray Methods. Microscopy and Microanalysis. 24:364-365. 2018
- Biomineralization at Titanium Revealed by Correlative 4D Tomographic and Spectroscopic Methods. Advanced Materials Interfaces. 5. 2018
- Morphology of cross-linked cellulose nanocrystal aerogels: cryo-templating versus pressurized gas expansion processing. Journal of Materials Science. 53:9842-9860. 2018
- Characterization and evaluation of femtosecond laser-induced sub-micron periodic structures generated on titanium to improve osseointegration of implants. Applied Surface Science. 441:1034-1042. 2018
- Micrometer-Sized Magnesium Whitlockite Crystals in Micropetrosis of Bisphosphonate-Exposed Human Alveolar Bone. Nano Letters. 17:6210-6216. 2017
- Influence of Substrate Heating and Nitrogen Flow on the Composition, Morphological and Mechanical Properties of SiNx Coatings Aimed for Joint Replacements. Materials. 10:173-173. 2017
- 3D Characterization of Human Nano-osseointegration by On-Axis Electron Tomography without the Missing Wedge. ACS Biomaterial Science and Engineering. 3:49-55. 2017
- Atomic scale chemical tomography of human bone. Scientific Reports. 7:39958. 2017
- Osseointegration of a 3D Printed Stemmed Titanium Dental Implant: A Pilot Study. International Journal of Dentistry. 2017:1-11. 2017
- Transparent single crystalline ZrO2-SiO2 glass nanoceramic sintered by SPS. Journal of the European Ceramic Society. 36:3487-3494. 2016
- Biomineralization of Hydroxyapatite Revealed by in situ Electron Microscopy. Microscopy and Microanalysis. 22:746-747. 2016
- Dual-topography electrical discharge machining of titanium to improve biocompatibility. Surface and Coatings Technology. 296:149-156. 2016
- Surface and Subsurface Analyses of Metal-on-Polyethylene Total Hip Replacement Retrievals. Journal of Bioengineering. 44:1685-1697. 2016
- Effect of proteoglycans at interfaces as related to location, architecture, and mechanical cues. Archives of Oral Biology. 63:82-92. 2016
- Synthesis of calcium phosphate crystals with thin nacreous structure. CrystEngComm. 18:1064-1069. 2016
- Strain-guided mineralization in the bone–PDL–cementum complex of a rat periodontium. Bone Reports. 3:20-31. 2015
- Biomineralization at Interfaces Revealed with 4D Electron and Atom Probe Tomographies. Microscopy and Microanalysis. 21:83-84. 2015
- High-Resolution Visualization of the Osteocyte Lacuno-Canalicular Network Juxtaposed to the Surface of Nanotextured Titanium Implants in Human. ACS Biomaterial Science and Engineering. 1:305-313. 2015
- Bone, implants, and their interfaces. Physics Today. 68:40-45. 2015
- Fabrication of translucent nanoceramics via a simple filtration method. RSC Advances. 5:99848-99855. 2015
- Three-dimensional analytical techniques for evaluation of osseointegrated titanium implants. Materials Science and Technology. 31:174-179. 2015
- Atomic layer deposition-based tuning of the pore size in mesoporous thin films studied by in situ grazing incidence small angle X-ray scattering. Nanoscale. 6:14991-14998. 2014
- FIB Preparation of Bone-Implant Interfaces for Correlative On-Axis Rotation Electron Tomography and Atom Probe Tomography. Microscopy and Microanalysis. 20:352-353. 2014
- From Micro to Nano: Correlative 3D Microscopies for Analysis of Biointerfaces. Microscopy and Microanalysis. 20:962-963. 2014
- The narwhal (Monodon monoceros) cementum–dentin junction: A functionally graded biointerphase. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 228:754-767. 2014
- Characterization of dental interfaces with electron tomography. Biointerphases. 9:029001. 2014
- Correction: A Template-Free, Ultra-Adsorbing, High Surface Area Carbonate Nanostructure. PLoS ONE. 9:10.1371/annotation/0878101b-450f-44a9-abd5-b2434957a698. 2014
- The plastic nature of the human bone–periodontal ligament–tooth fibrous joint. Bone. 57:455-467. 2013
- Three-dimensional structure of laser-modified Ti6Al4V and bone interface revealed with STEM tomography. Ultramicroscopy. 127:48-52. 2013
- A Template-Free, Ultra-Adsorbing, High Surface Area Carbonate Nanostructure. PLoS ONE. 8:e68486-e68486. 2013
- Effect of Calcium and Strontium on Mesoporous Titania Coatings for Implant Applications. Journal of Biomaterials and Nanobiotechnology. 04:107-113. 2013
- Where bone meets implant: the characterization of nano-osseointegration. Nanoscale. 5:4302-4302. 2013
- Fabrication and evaluation of SixNy coatings for total joint replacements. Journal of Materials Science: Materials in Medicine. 23:1879-1889. 2012
- In Situ Study of ALD Processes Using Synchrotron-based X-ray Fluorescence and Scattering Techniques. ECS Meeting Abstracts. MA2012-02:2460-2460. 2012
- Bone Response to Free‐Form Fabricated Hydroxyapatite and Zirconia Scaffolds: A Transmission Electron Microscopy Study in the Human Maxilla. Clinical Implant Dentistry and Related Research. 14:461-469. 2012
- High-resolution three-dimensional probes of biomaterials and their interfaces. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 370:1337-1351. 2012
- Bone–titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography. Journal of the Royal Society Interface. 9:396-400. 2012
- Focused Ion Beam in the Study of Biomaterials and Biological Matter. Advances in Materials Science and Engineering. 2012:1-6. 2012
- Mesoporous titanium dioxide coating for metallic implants. Journal of Biomedical Materials Research - Part B Applied Biomaterials. 100B:82-93. 2012
- Resolving the CaP-bone interface. Biomatter. 2:15-23. 2012
- Ultrastructural characterisation of the hydroxyapatite-coated pedicle screw and human bone interface. International Journal of Nano and Biomaterials. 4:1-1. 2012
- Synthesis and release of trace elements from hollow and porous hydroxyapatite spheres. Nanotechnology. 22:305610-305610. 2011
- Free form fabricated features on CoCr implants with and without hydroxyapatite coating in vivo: a comparative study of bone contact and bone growth induction. Journal of Materials Science: Materials in Medicine. 22:899-906. 2011
- Visualizing biointerfaces in three dimensions: electron tomography of the bone–hydroxyapatite interface. Journal of the Royal Society Interface. 7:1497-1501. 2010
- Electrophoretic deposition of polymer-carbon nanotube–hydroxyapatite composites. Surface and Coatings Technology. 203:1481-1487. 2009
- Electrophoretic deposition of composite hydroxyapatite–silica–chitosan coatings. Materials Characterization. 59:61-67. 2008
- Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice. Journal of Visualized Experiments.
other
- 2020 Proceedings of the 3rd International Conference on Trauma Surgery Technology in Giessen 2020
preprints
theses
- Characterization of Biomaterial-Bone Interfaces with Transmission Electron Microscopy 2010