Quantitative Trait Loci Concept

subject area of

• A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression  Academic Article
• A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease  Academic Article
• A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease  Academic Article
• A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression  Academic Article
• Analytical strategies to include the X‐chromosome in variance heterogeneity analyses: Evidence for trait‐specific polygenic variance structure  Academic Article
• Association Analysis Indicates That a Variant GATA-Binding Site in the PIK3CB Promoter Is a Cis-Acting Expression Quantitative Trait Locus for This Gene and Attenuates Insulin Resistance in Obese Children  Academic Article
• Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3  Academic Article
• BCL11A is a major HbF quantitative trait locus in three different populations with β-hemoglobinopathies  Academic Article
• Causes and Consequences of Genetic Background Effects Illuminated by Integrative Genomic Analysis  Academic Article
• Common variants near MC4R are associated with fat mass, weight and risk of obesity  Academic Article
• Contribution of Large Region Joint Associations to Complex Traits Genetics  Academic Article
• Correction of chromosomal mutation and random integration in embryonic stem cells with helper-dependent adenoviral vectors  Academic Article
• Dynamic interaction between fetal adversity and a genetic score reflecting dopamine function on developmental outcomes at 36 months  Academic Article
• Fetal globin gene inducers: novel agents and new potential  Academic Article
• Fetal hemoglobin in sickle cell anemia: Molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans  Academic Article
• Fetal hemoglobin in sickle cell anemia: Saudi patients from the Southwestern province have similar HBB haplotypes but higher HbF levels than African Americans  Academic Article
• Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci  Academic Article
• Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits  Academic Article
• Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias  Academic Article
• Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2  Academic Article
• Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations  Academic Article
• Genome-wide linkage analysis of systolic blood pressure slope using the Genetic Analysis Workshop 13 data sets  Academic Article
• Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture  Academic Article
• Identification of Genetic Loci Underlying the Phenotypic Constructs of Autism Spectrum Disorders  Academic Article
• Identification of QTLs Associated with Virulence Related Traits and Drug Resistance in Cryptococcus neoformans  Academic Article
• Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity  Academic Article
• K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population  Academic Article
• Large meta-analysis of genome-wide association studies identifies five loci for lean body mass  Academic Article
• Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci  Academic Article
• Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation  Academic Article
• MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans  Academic Article
• Meta-analysis of SNPs involved in variance heterogeneity using Levene’s test for equal variances  Academic Article
• Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction  Academic Article
• Multi-ethnic genome-wide association study for atrial fibrillation  Academic Article
• Multilocus sequence analyses reveal extensive diversity and multiple origins of fluconazole resistance in Candida tropicalis from tropical China  Academic Article
• New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders  Academic Article
• New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk  Academic Article
• On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study  Academic Article
• Penetrance of Polygenic Obesity Susceptibility Loci across the Body Mass Index Distribution  Academic Article
• Probability genotype imputation method and integrated weighted lasso for QTL identification  Academic Article
• Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions  Academic Article
• Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study  Academic Article
• Sex- and age-interacting eQTLs in human complex diseases  Academic Article
• Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2  Academic Article
• TCF7L2 Variation Predicts Hyperglycemia Incidence in a French General Population: The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study  Academic Article
• The LASSO and Sparse Least Squares Regression Methods for SNP Selection in Predicting Quantitative Traits  Academic Article
• The association of HBG2 , BCL11A, and HMIP polymorphisms with fetal hemoglobin and clinical phenotype in Iraqi Kurds with sickle cell disease  Academic Article
• The genetic basis of asymptomatic codon 8 frame-shift (HBB:c25_26delAA) β0-thalassaemia homozygotes  Academic Article
• Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies  Academic Article
• α+-Thalassemia Trait Caused by a Frameshift Mutation in Exon 2 of the α2-Globin Gene [HBA2 c.244delT]  Academic Article