Quantitative Trait Loci Concept

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• A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression  Journal Articles
• A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease  Journal Articles
• A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease  Journal Articles
• A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression  Journal Articles
• A principal component regression based genome wide analysis approach reveals the presence of a novel QTL on BTA7 for MAP resistance in holstein cattle  Journal Articles
• Analytical strategies to include the X‐chromosome in variance heterogeneity analyses: Evidence for trait‐specific polygenic variance structure  Journal Articles
• Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3  Journal Articles
• BCL11A is a major HbF quantitative trait locus in three different populations with β-hemoglobinopathies  Journal Articles
• CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer  Journal Articles
• Causes and Consequences of Genetic Background Effects Illuminated by Integrative Genomic Analysis  Journal Articles
• Contribution of Large Region Joint Associations to Complex Traits Genetics  Journal Articles
• Correction of chromosomal mutation and random integration in embryonic stem cells with helper-dependent adenoviral vectors  Journal Articles
• Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.  Journal Articles
• Dynamic interaction between fetal adversity and a genetic score reflecting dopamine function on developmental outcomes at 36 months  Journal Articles
• Fetal globin gene inducers: novel agents and new potential  Journal Articles
• Fetal hemoglobin in sickle cell anemia: Molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans  Journal Articles
• Fetal hemoglobin in sickle cell anemia: Saudi patients from the Southwestern province have similar HBB haplotypes but higher HbF levels than African Americans  Journal Articles
• Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci  Journal Articles
• Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits  Journal Articles
• Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias  Journal Articles
• Genome-wide association analysis identifies six new loci associated with forced vital capacity  Journal Articles
• Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2  Journal Articles
• Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer  Journal Articles
• Genome-wide germline correlates of the epigenetic landscape of prostate cancer  Journal Articles
• Genome-wide linkage analysis of systolic blood pressure slope using the Genetic Analysis Workshop 13 data sets  Journal Articles
• Genome‐wide study identifies novel genes associated with bone toxicities in children with acute lymphoblastic leukaemia  Journal Articles
• Identification of Genetic Loci Underlying the Phenotypic Constructs of Autism Spectrum Disorders  Journal Articles
• Identification of QTLs Associated with Virulence Related Traits and Drug Resistance in Cryptococcus neoformans  Journal Articles
• Integrative Genetic Variation, DNA Methylation, and Gene Expression Analysis of Escitalopram and Aripiprazole Treatment Outcomes in Depression: A CAN-BIND-1 Study  Journal Articles
• K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population  Journal Articles
• Large meta-analysis of genome-wide association studies identifies five loci for lean body mass  Journal Articles
• Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci  Journal Articles
• Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation  Journal Articles
• Meta-analysis of SNPs involved in variance heterogeneity using Levene’s test for equal variances  Journal Articles
• Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction  Journal Articles
• Multi-ethnic genome-wide association study for atrial fibrillation  Journal Articles
• Multilocus sequence analyses reveal extensive diversity and multiple origins of fluconazole resistance in Candida tropicalis from tropical China  Journal Articles
• New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders  Journal Articles
• On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study  Journal Articles
• Penetrance of Polygenic Obesity Susceptibility Loci across the Body Mass Index Distribution  Journal Articles
• Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions  Journal Articles
• Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study  Journal Articles
• SNPs in the bovine IL-10 receptor are associated with somatic cell score in Canadian dairy bulls  Journal Articles
• Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2  Journal Articles
• The LASSO and Sparse Least Squares Regression Methods for SNP Selection in Predicting Quantitative Traits  Journal Articles
• The association of HBG2, BCL11A, and HMIP polymorphisms with fetal hemoglobin and clinical phenotype in Iraqi Kurds with sickle cell disease  Journal Articles
• The genetic basis of asymptomatic codon 8 frame‐shift (HBB:c25_26delAA) β⁰‐thalassaemia homozygotes  Journal Articles
• Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies  Journal Articles
• eQTL Set–Based Association Analysis Identifies Novel Susceptibility Loci for Barrett Esophagus and Esophageal Adenocarcinoma  Journal Articles
• α⁺-Thalassemia Trait Caused by a Frameshift Mutation in Exon 2 of the α2-Globin Gene [HBA2 c.244delT]  Journal Articles