Journal article
Penetrance of Polygenic Obesity Susceptibility Loci across the Body Mass Index Distribution
Abstract
A growing number of single-nucleotide polymorphisms (SNPs) have been associated with body mass index (BMI) and obesity, but whether the effects of these obesity-susceptibility loci are uniform across the BMI distribution remains unclear. We studied the effects of 37 BMI-associated SNPs in 75,230 adults of European ancestry across BMI percentiles by using conditional quantile regression (CQR) and meta-regression (MR) models. The effects of nine …
Authors
Abadi A; Alyass A; du Pont SR; Bolker B; Singh P; Mohan V; Diaz R; Engert JC; Yusuf S; Gerstein HC
Journal
American Journal of Human Genetics, Vol. 101, No. 6, pp. 925–938
Publisher
Elsevier
Publication Date
December 2017
DOI
10.1016/j.ajhg.2017.10.007
ISSN
0002-9297