Journal article
A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease
Abstract
Genome-wide association studies (GWAS), relying on hundreds of thousands of individuals, have revealed >200 genomic loci linked to metabolic disease (MD). Loss of insulin sensitivity (IS) is a key component of MD and we hypothesized that discovery of a robust IS transcriptome would help reveal the underlying genomic structure of MD. Using 1,012 human skeletal muscle samples, detailed physiology and a tissue-optimized approach for the …
Authors
Timmons JA; Atherton PJ; Larsson O; Sood S; Blokhin IO; Brogan RJ; Volmar C-H; Josse AR; Slentz C; Wahlestedt C
Journal
Nucleic Acids Research, Vol. 46, No. 15,
Publisher
Oxford University Press (OUP)
Publication Date
September 6, 2018
DOI
10.1093/nar/gky570
ISSN
0305-1048