Journal article
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias
Abstract
Alzheimer's disease (AD) and related dementias are a major public health challenge and present a therapeutic imperative for which we need additional insight into molecular pathogenesis. We performed a genome-wide association study and analysis of known genetic risk loci for AD dementia using neuropathologic data from 4,914 brain autopsies. Neuropathologic data were used to define clinico-pathologic AD dementia or controls, assess core …
Authors
Beecham GW; Hamilton K; Naj AC; Martin ER; Huentelman M; Myers AJ; Corneveaux JJ; Hardy J; Vonsattel J-P; Younkin SG
Journal
PLOS Genetics, Vol. 10, No. 9,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pgen.1004606
ISSN
1553-7390
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ATP Binding Cassette Transporter, Subfamily G, Member 1ATP-Binding Cassette TransportersAlzheimer DiseaseBrainCase-Control StudiesChromosome MappingChromosomes, Human, Pair 18Chromosomes, Human, Pair 9DementiaGenetic Predisposition to DiseaseGenome-Wide Association StudyHippocampusHumansN-AcetylgalactosaminyltransferasesOdds RatioPhenotypePlaque, AmyloidQuantitative Trait Loci