Journal article
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
Abstract
Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for …
Authors
Ferreira MA; Gamazon ER; Al-Ejeh F; Aittomäki K; Andrulis IL; Anton-Culver H; Arason A; Arndt V; Aronson KJ; Arun BK
Journal
Nature Communications, Vol. 10, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-018-08053-5
ISSN
2041-1723