Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits Academic Article uri icon

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abstract

  • High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

authors

  • Evangelou, Evangelos
  • Warren, Helen R
  • Mosen-Ansorena, David
  • Mifsud, Borbala
  • Pazoki, Raha
  • Gao, He
  • Ntritsos, Georgios
  • Dimou, Niki
  • Cabrera, Claudia P
  • Karaman, Ibrahim
  • Ng, Fu Liang
  • Evangelou, Marina
  • Witkowska, Katarzyna
  • Tzanis, Evan
  • Hellwege, Jacklyn N
  • Giri, Ayush
  • Velez Edwards, Digna R
  • Sun, Yan V
  • Cho, Kelly
  • Gaziano, J Michael
  • Wilson, Peter WF
  • Tsao, Philip S
  • Kovesdy, Csaba P
  • Esko, Tonu
  • Mägi, Reedik
  • Milani, Lili
  • Almgren, Peter
  • Boutin, Thibaud
  • Debette, Stéphanie
  • Ding, Jun
  • Giulianini, Franco
  • Holliday, Elizabeth G
  • Jackson, Anne U
  • Li-Gao, Ruifang
  • Lin, Wei-Yu
  • Luan, Jian’an
  • Mangino, Massimo
  • Oldmeadow, Christopher
  • Prins, Bram Peter
  • Qian, Yong
  • Sargurupremraj, Muralidharan
  • Shah, Nabi
  • Surendran, Praveen
  • Thériault, Sébastien
  • Verweij, Niek
  • Willems, Sara M
  • Zhao, Jing-Hua
  • Amouyel, Philippe
  • Connell, John
  • de Mutsert, Renée
  • Doney, Alex SF
  • Farrall, Martin
  • Menni, Cristina
  • Morris, Andrew D
  • Noordam, Raymond
  • Pare, Guillaume
  • Poulter, Neil R
  • Shields, Denis C
  • Stanton, Alice
  • Thom, Simon
  • Abecasis, Gonçalo
  • Amin, Najaf
  • Arking, Dan E
  • Ayers, Kristin L
  • Barbieri, Caterina M
  • Batini, Chiara
  • Bis, Joshua C
  • Blake, Tineka
  • Bochud, Murielle
  • Boehnke, Michael
  • Boerwinkle, Eric
  • Boomsma, Dorret I
  • Bottinger, Erwin P
  • Braund, Peter S
  • Brumat, Marco
  • Campbell, Archie
  • Campbell, Harry
  • Chakravarti, Aravinda
  • Chambers, John C
  • Chauhan, Ganesh
  • Ciullo, Marina
  • Cocca, Massimiliano
  • Collins, Francis
  • Cordell, Heather J
  • Davies, Gail
  • de Borst, Martin H
  • de Geus, Eco J
  • Deary, Ian J
  • Deelen, Joris
  • Del Greco M., Fabiola
  • Demirkale, Cumhur Yusuf
  • Dörr, Marcus
  • Ehret, Georg B
  • Elosua, Roberto
  • Enroth, Stefan
  • Erzurumluoglu, A Mesut
  • Ferreira, Teresa
  • Frånberg, Mattias
  • Franco, Oscar H
  • Gandin, Ilaria
  • Gasparini, Paolo
  • Giedraitis, Vilmantas
  • Gieger, Christian
  • Girotto, Giorgia
  • Goel, Anuj
  • Gow, Alan J
  • Gudnason, Vilmundur
  • Guo, Xiuqing
  • Gyllensten, Ulf
  • Hamsten, Anders
  • Harris, Tamara B
  • Harris, Sarah E
  • Hartman, Catharina A
  • Havulinna, Aki S
  • Hicks, Andrew A
  • Hofer, Edith
  • Hofman, Albert
  • Hottenga, Jouke-Jan
  • Huffman, Jennifer E
  • Hwang, Shih-Jen
  • Ingelsson, Erik
  • James, Alan
  • Jansen, Rick
  • Jarvelin, Marjo-Riitta
  • Joehanes, Roby
  • Johansson, Åsa
  • Johnson, Andrew D
  • Joshi, Peter K
  • Jousilahti, Pekka
  • Jukema, J Wouter
  • Jula, Antti
  • Kähönen, Mika
  • Kathiresan, Sekar
  • Keavney, Bernard D
  • Khaw, Kay-Tee
  • Knekt, Paul
  • Knight, Joanne
  • Kolcic, Ivana
  • Kooner, Jaspal S
  • Koskinen, Seppo
  • Kristiansson, Kati
  • Kutalik, Zoltan
  • Laan, Maris
  • Larson, Marty
  • Launer, Lenore J
  • Lehne, Benjamin
  • Lehtimäki, Terho
  • Liewald, David CM
  • Lin, Li
  • Lind, Lars
  • Lindgren, Cecilia M
  • Liu, YongMei
  • Loos, Ruth JF
  • Lopez, Lorna M
  • Lu, Yingchang
  • Lyytikäinen, Leo-Pekka
  • Mahajan, Anubha
  • Mamasoula, Chrysovalanto
  • Marrugat, Jaume
  • Marten, Jonathan
  • Milaneschi, Yuri
  • Morgan, Anna
  • Morris, Andrew P
  • Morrison, Alanna C
  • Munson, Peter J
  • Nalls, Mike A
  • Nandakumar, Priyanka
  • Nelson, Christopher P
  • Niiranen, Teemu
  • Nolte, Ilja M
  • Nutile, Teresa
  • Oldehinkel, Albertine J
  • Oostra, Ben A
  • O’Reilly, Paul F
  • Org, Elin
  • Padmanabhan, Sandosh
  • Palmas, Walter
  • Palotie, Aarno
  • Pattie, Alison
  • Penninx, Brenda WJH
  • Perola, Markus
  • Peters, Annette
  • Polasek, Ozren
  • Pramstaller, Peter P
  • Nguyen, Quang Tri
  • Raitakari, Olli T
  • Ren, Meixia
  • Rettig, Rainer
  • Rice, Kenneth
  • Ridker, Paul M
  • Ried, Janina S
  • Riese, Harriëtte
  • Ripatti, Samuli
  • Robino, Antonietta
  • Rose, Lynda M
  • Rotter, Jerome I
  • Rudan, Igor
  • Ruggiero, Daniela
  • Saba, Yasaman
  • Sala, Cinzia F
  • Salomaa, Veikko
  • Samani, Nilesh J
  • Sarin, Antti-Pekka
  • Schmidt, Reinhold
  • Schmidt, Helena
  • Shrine, Nick
  • Siscovick, David
  • Smith, Albert V
  • Snieder, Harold
  • Sõber, Siim
  • Sorice, Rossella
  • Starr, John M
  • Stott, David J
  • Strachan, David P
  • Strawbridge, Rona J
  • Sundström, Johan
  • Swertz, Morris A
  • Taylor, Kent D
  • Teumer, Alexander
  • Tobin, Martin D
  • Tomaszewski, Maciej
  • Toniolo, Daniela
  • Traglia, Michela
  • Trompet, Stella
  • Tuomilehto, Jaakko
  • Tzourio, Christophe
  • Uitterlinden, André G
  • Vaez, Ahmad
  • van der Most, Peter J
  • van Duijn, Cornelia M
  • Vergnaud, Anne-Claire
  • Verwoert, Germaine C
  • Vitart, Veronique
  • Völker, Uwe
  • Vollenweider, Peter
  • Vuckovic, Dragana
  • Watkins, Hugh
  • Wild, Sarah H
  • Willemsen, Gonneke
  • Wilson, James F
  • Wright, Alan F
  • Yao, Jie
  • Zemunik, Tatijana
  • Zhang, Weihua
  • Attia, John R
  • Butterworth, Adam S
  • Chasman, Daniel I
  • Conen, David
  • Cucca, Francesco
  • Danesh, John
  • Hayward, Caroline
  • Howson, Joanna MM
  • Laakso, Markku
  • Lakatta, Edward G
  • Langenberg, Claudia
  • Melander, Olle
  • Mook-Kanamori, Dennis O
  • Palmer, Colin NA
  • Risch, Lorenz
  • Scott, Robert A
  • Scott, Rodney J
  • Sever, Peter
  • Spector, Tim D
  • van der Harst, Pim
  • Wareham, Nicholas J
  • Zeggini, Eleftheria
  • Levy, Daniel
  • Munroe, Patricia B
  • Newton-Cheh, Christopher
  • Brown, Morris J
  • Metspalu, Andres
  • Hung, Adriana M
  • O’Donnell, Christopher J
  • Edwards, Todd L
  • Psaty, Bruce M
  • Tzoulaki, Ioanna
  • Barnes, Michael R
  • Wain, Louise V
  • Elliott, Paul
  • Caulfield, Mark J

publication date

  • October 2018

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