Journal article
BCL11A is a major HbF quantitative trait locus in three different populations with β-hemoglobinopathies
Abstract
Increased HbF levels or F-cell (HbF containing erythrocyte) numbers can ameliorate the disease severity of beta-thalassemia major and sickle cell anemia. Recent genome-wide association studies reported that single nucleotide polymorphisms (SNPs) in BCL11A gene on chromosome 2p16.1 were correlated with F-cells among healthy northern Europeans, and HbF among Sardinians with beta-thalassemias. In this study, we showed that SNPs in BCL11A were …
Authors
Sedgewick AE; Timofeev N; Sebastiani P; So JCC; S.K. E; Chan LC; Fucharoen G; Fucharoen S; Barbosa CG; Vardarajan BN
Journal
Blood Cells Molecules and Diseases, Vol. 41, No. 3, pp. 255–258
Publisher
Elsevier
Publication Date
11 2008
DOI
10.1016/j.bcmd.2008.06.007
ISSN
1079-9796