Molecular Targeted Therapy Concept

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2017 Scientific Sessions Sol Sherry Distinguished Lecture in Thrombosis Journal Articles
GRIN2Bencephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects Journal Articles
A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria Journal Articles
A new frontier in treatment of advanced melanoma: Redefining clinical management in the era of immune checkpoint inhibitors Journal Articles
A phase II study of sunitinib in recurrent and/or metastatic adenoid cystic carcinoma (ACC) of the salivary glands: current progress and challenges in evaluating molecularly targeted agents in ACC Conferences
A platelet cover-up Journal Articles
A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy Journal Articles
AMPK as a Therapeutic Target for Treating Metabolic Diseases Journal Articles
Aberrant Epigenetic Regulation: A Central Contributor to Lung Carcinogenesis and a New Therapeutic Target Journal Articles
Advancing Novel Molecular Imaging Agents from Preclinical Studies to First-in-Humans Phase I Clinical Trials in Academia—A Roadmap for Overcoming Perceived Barriers Journal Articles
Antialarmins for treatment of asthma Journal Articles
Arachidonic Acid Metabolism and Kidney Inflammation. Journal Articles
Biology and patterns of response to EGFR-inhibition in squamous cell cancers of the lung and head & neck Journal Articles
Biomarkers of Response and Resistance to CDK4/6 Inhibitors in Breast Cancer: Hints from Liquid Biopsy and microRNA Exploration Journal Articles
Brain Metastases in Non–Small-Cell Lung Cancer Journal Articles
Breaking the biomarker code: PD-L1 expression and checkpoint inhibition in advanced NSCLC Journal Articles
Cardiovascular toxicities of BCR-ABL tyrosine kinase inhibitors in chronic myeloid leukemia: preventive strategies and cardiovascular surveillance Journal Articles
Catechins as Tools to Understand the Molecular Basis of Neurodegeneration Journal Articles
Delineation of key XRCC4/Ligase IV interfaces for targeted disruption of non-homologous end joining DNA repair Journal Articles
Depressive disorders: Processes leading to neurogeneration and potential novel treatments Journal Articles
Durable Clinical Benefit in Metastatic Renal Cell Carcinoma Patients Who Discontinue PD-1/PD-L1 Therapy for Immune-Related Adverse Events Journal Articles
EMT: Mechanisms and therapeutic implications Journal Articles
Emerging Biomarker-Guided Therapies in Prostate Cancer Journal Articles
Emerging airway smooth muscle targets to treat asthma Journal Articles
Emerging monoclonal antibodies as targeted innovative therapeutic approaches to asthma Journal Articles
Eosinophil Lineage-Committed Progenitors as a Therapeutic Target for Asthma Journal Articles
Epidermal Growth Factor Receptor: Pathway, Therapies, and Pipeline Journal Articles
Epithelial-Derived Cytokines in Asthma Journal Articles
Estrogen Receptor β Is a Novel Target in Acute Myeloid Leukemia Journal Articles
Evaluating the evidence for macrophage presence in skeletal muscle and its relation to insulin resistance in obese mice and humans: a systematic review protocol Journal Articles
Extracellular Heat Shock Proteins as Therapeutic Targets and Biomarkers in Fibrosing Interstitial Lung Diseases Journal Articles
Factor XI and factor XII as targets for new anticoagulants Journal Articles
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease Journal Articles
Glycopeptide antibiotic biosynthesis Journal Articles
HSP47: a potential target for fibrotic diseases and implications for therapy Journal Articles
IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII Journal Articles
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease Journal Articles
Immune checkpoint-inhibitors and chemoradiation in stage III unresectable non-small cell lung cancer Journal Articles
Intraductal Adaptation of the 4T1 Mouse Model of Breast Cancer Reveals Effects of the Epithelial Microenvironment on Tumor Progression and Metastasis Journal Articles
Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial Journal Articles
Landscape review of current HIV ‘kick and kill’ cure research - some kicking, not enough killing Journal Articles
Ligand action on sodium, potassium, and calcium channels: role of permeant ions Journal Articles
Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis Journal Articles
Management of advanced or recurrent cervical cancer: chemotherapy and beyond Journal Articles
Mars Shot for Nuclear Medicine, Molecular Imaging, and Molecularly Targeted Radiopharmaceutical Therapy Journal Articles
Mechanism and non-mechanism based imaging biomarkers for assessing biological response to treatment in non-small cell lung cancer Journal Articles
Mechanisms of Cardiovascular Toxicity of BCR-ABL1 Tyrosine Kinase Inhibitors in Chronic Myelogenous Leukemia Journal Articles
Modern era systemic therapies: Expanding concepts of cure in early and locally advanced non‐small cell lung cancer Journal Articles
Molecular Imaging and Precision Medicine in Lung Cancer Journal Articles
Molecular mechanisms of membrane targeting antibiotics Journal Articles
Network meta-analysis of therapies for previously untreated advanced BRAF-mutated melanoma Journal Articles
New therapeutic strategies to treat human cancers expressing mutant p53 proteins Journal Articles
New treatment and markers of prognosis for idiopathic pulmonary fibrosis: lessons learned from translational research Journal Articles
Novel treatments for immune thrombocytopenia: targeting platelet autoantibodies Journal Articles
Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial Journal Articles
Optimizing Survival and the Changing Landscape of Targeted Therapy for Intermediate and Advanced Hepatocellular Carcinoma: A Systematic Review Journal Articles
Outcomes in patients with advanced urothelial carcinoma after discontinuation of programmed death (PD)‐1 or PD ligand 1 inhibitor therapy Journal Articles
Personalizing the Treatment of Pediatric Medulloblastoma: Polo-like Kinase 1 as a Molecular Target in High-Risk Children Journal Articles
Phase 1/2 Study of the CD56-Targeting Antibody-Drug Conjugate Lorvotuzumab Mertansine (IMGN901) in Combination With Carboplatin/Etoposide in Small-Cell Lung Cancer Patients With Extensive-Stage Disease Journal Articles
Pneumatosis Intestinalis and Bowel Perforation Associated With Molecular Targeted Therapy: An Emerging Problem and the Role of Radiologists in Its Management Journal Articles
Polo-Like Kinase 1 Inhibition Kills Glioblastoma Multiforme Brain Tumor Cells in Part Through Loss of SOX2 and Delays Tumor Progression in Mice Journal Articles
Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: Examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia Journal Articles
Proton Pump Inhibitors and Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma Journal Articles
Randomized controlled trials in the era of molecular oncology: methodology, biomarkers, and end points Journal Articles
Real-World Benefit of Nivolumab in A Canadian Non-Small-Cell Lung Cancer Cohort Journal Articles
Real-world Assessment of Clinical Outcomes in Patients with Metastatic Renal Cell Carcinoma with or Without Sarcomatoid Features Treated with First-line Systemic Therapies Journal Articles
Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective Journal Articles
Recent insights into neuromuscular junction biology in Duchenne muscular dystrophy: Impacts, challenges, and opportunities Journal Articles
Review of Cytotoxic CA4 Analogues that Do Not Target Microtubules: Implications for CA4 Development. Journal Articles
Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial Journal Articles
Soluble Human IL-1 Receptor Type 2 Inhibits Ectopic Endometrial Tissue Implantation and Growth Journal Articles
Stroke genetics informs drug discovery and risk prediction across ancestries Journal Articles
Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy Journal Articles
Systemic Therapy for Previously Untreated Advanced BRAF -Mutated Melanoma: Navigating a Shifting Landscape Journal Articles
Systemic Therapy for Previously Untreated Advanced BRAF-Mutated Melanoma Journal Articles
Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update Journal Articles
Systemic adjuvant therapy for adult patients at high risk for recurrent melanoma: A systematic review Journal Articles
Taking aim at wall teichoic acid synthesis: new biology and new leads for antibiotics Journal Articles
Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages Journal Articles
Targeted and Non-Targeted Mechanisms for Killing Hypoxic Tumour Cells—Are There New Avenues for Treatment? Journal Articles
Targeted radionuclide therapy in combined-modality regimens Journal Articles
Targeted therapy of bronchitis in obstructive airway diseases Journal Articles
Targeting Cholesterol Crystal-Induced Inflammation for the Secondary Prevention of Cardiovascular Disease Journal Articles
The Clinical Activity of PD-1/PD-L1 Inhibitors in Metastatic Non–Clear Cell Renal Cell Carcinoma Journal Articles
The Role of the TL1A/DR3 Axis in the Activation of Group 2 Innate Lymphoid Cells in Subjects with Eosinophilic Asthma Journal Articles
The rapidly evolving landscape of novel targeted therapies in advanced non-small cell lung cancer Journal Articles
Therapeutic Targeting of the Premetastatic Stage in Human Lung-to-Brain Metastasis Journal Articles
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling Journal Articles
Therapeutic targets and early stage clinical trials for pulmonary fibrosis Journal Articles
Therapeutic targets in idiopathic pulmonary fibrosis Journal Articles
Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma Journal Articles
Treatment of mCRPC in the AR-axis-targeted therapy-resistant state Conferences
Tumor-Targeting Domains for Chimeric Antigen Receptor T Cells Journal Articles
Tyrosine Kinase Inhibitor Therapy in Unresectable Locally Advanced NSCLC: Keep Holding Our Breaths or Time to Take a Breather? Journal Articles
USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation Journal Articles
What have we learned from basic science studies on idiopathic pulmonary fibrosis? Journal Articles
Whether it is personalized, precision, or mechanistic medicine - the clinical laboratory has a role Journal Articles