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Identification of new susceptibility loci for type...
Journal article

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

Abstract

Danish Saleheen, Benjamin Voight and colleagues perform genome-wide analysis of multi-ancestry cohorts to identify genetic associations with type 2 diabetes (T2D) and coronary heart disease (CHD). They find novel loci and show that 24% of T2D loci are also associated with CHD and that greater genetic risk of T2D increases risk of CHD.

Authors

Zhao W; Rasheed A; Tikkanen E; Lee J-J; Butterworth AS; Howson JMM; Assimes TL; Chowdhury R; Orho-Melander M; Damrauer S

Journal

Nature Genetics, Vol. 49, No. 10, pp. 1450–1457

Publisher

Springer Nature

Publication Date

October 1, 2017

DOI

10.1038/ng.3943

ISSN

1061-4036

Associated Experts

Guillaume Pare

Professor, Faculty of Health Sciences
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Sonia Anand

Professor, Faculty of Health Sciences
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Labels

Fields of Research (FoR)

31 Biological Sciences3105 Genetics3001 Agricultural biotechnology3102 Bioinformatics and computational biology

Medical Subject Headings (MeSH)

AsiaAsian PeopleBiomarkersComorbidityCoronary DiseaseDiabetes Mellitus, Type 2EuropeGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHLA-DRB5 ChainsHumansMetabolic Networks and PathwaysMetabolic SyndromeMolecular Targeted TherapyMutation, MissensePolymorphism, Single NucleotideRisk FactorsWhite People
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