Hepatocytes Concept

subject area of

• AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance  Journal Articles
• Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models  Journal Articles
• Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance  Journal Articles
• Cell Adhesion on a POEGMA-Modified Topographical Surface  Journal Articles
• Chromatin Dynamics of Gene Activation and Repression in Response to Interferon α (IFNα) Reveal New Roles for Phosphorylated and Unphosphorylated Forms of the Transcription Factor STAT2  Journal Articles
• Conversion of Low Density Lipoprotein-associated Phosphatidylcholine to Triacylglycerol by Primary Hepatocytes  Journal Articles
• Cytokine-Induced Hepatic Apoptosis Is Dependent on FGL2/Fibroleukin: The Role of Sp1/Sp3 and STAT1/PU.1 CompositecisElements  Journal Articles
• Deletion of Myeloid GSK3α Attenuates Atherosclerosis and Promotes an M2 Macrophage Phenotype  Journal Articles
• Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis  Journal Articles
• Effects of Methimazole on the Onset of Type 2 Diabetes in Leptin Receptor-Deficient Rats  Journal Articles
• Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism  Journal Articles
• Endoplasmic reticulum stress in adipose tissue augments lipolysis  Journal Articles
• Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662  Journal Articles
• Functional characterization of estrogen receptor subtypes, ERα and ERβ, mediating vitellogenin production in the liver of rainbow trout  Journal Articles
• Glucosamine-Induced Endoplasmic Reticulum Stress Promotes ApoB100 Degradation  Journal Articles
• Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms  Journal Articles
• Heat stress modulates hepatocyte membrane proteins during endotoxemia  Journal Articles
• Hexosamine biosynthesis pathway flux promotes endoplasmic reticulum stress, lipid accumulation, and inflammatory gene expression in hepatic cells  Journal Articles
• Homocysteine Metabolism in ZDF (Type 2) Diabetic Rats  Journal Articles
• IDENTIFICATION OF FACTORS CONTRIBUTING TO HEPATOMEGALY IN SEVERELY BURNED CHILDREN  Journal Articles
• IGF-I/BP-3 ADMINISTRATION PRESERVES HEPATIC HOMEOSTASIS AFTER THERMAL INJURY WHICH IS ASSOCIATED WITH INCREASES IN NO AND HEPATIC NF-κB  Journal Articles
• Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation  Journal Articles
• Insulin Decreases Inflammatory Signal Transcription Factor Expression in Primary Human Liver Cells after LPS Challenge  Journal Articles
• Insulin Treatment Improves Hepatic Morphology and Function Through Modulation of Hepatic Signals After Severe Trauma  Journal Articles
• Insulin acutely decreases hepatic fatty acid synthase activity  Journal Articles
• Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats  Journal Articles
• Integrated biological responses of zebrafish (Danio rerio) to analyze water quality in regions under anthropogenic influence  Journal Articles
• Iron Overload in Human Disease  Journal Articles
• Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency  Journal Articles
• Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis  Journal Articles
• Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained  Journal Articles
• Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor  Journal Articles
• Measurement of Hepatic Protein Fractional Synthetic Rate with Stable Isotope Labeling Technique in Thapsigargin Stressed HepG2 Cells  Journal Articles
• Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK  Journal Articles
• Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity  Journal Articles
• Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss  Journal Articles
• Microfabrication of AngioChip, a biodegradable polymer scaffold with microfluidic vasculature  Journal Articles
• Modeling Acute ER Stress in Vivo and in Vitro  Journal Articles
• Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate  Journal Articles
• NOD2 in hepatocytes engages a liver-gut axis to protect against steatosis, fibrosis, and gut dysbiosis during fatty liver disease in mice  Journal Articles
• Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site  Journal Articles
• Oncostatin M induces IL-33 expression in liver endothelial cells in mice and expands ST2⁺CD4⁺lymphocytes  Journal Articles
• Overexpression of the Endoplasmic Reticulum 60 Protein ER-60 Downregulates ApoB100 Secretion by Inducing Its Intracellular Degradation via a Nonproteasomal Pathway:  Evidence for an ER-60-Mediated and pCMB-Sensitive Intracellular Degradative Pathway  Journal Articles
• Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death  Journal Articles
• Prolonged Endoplasmic Reticulum–Stressed Hepatocytes Drive an Alternative Macrophage Polarization  Journal Articles
• Propagating factor IX-producing hepatocytes for haemophilia B therapy  Journal Articles
• Reactive oxygen species generation and expression of DNA repair-related genes after copper exposure in zebrafish (Danio rerio) ZFL cells  Journal Articles
• Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice  Journal Articles
• Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1  Journal Articles
• Small hepatitis B surface antigen interacts with and modulates enoyl-coenzyme A hydratase expression in hepatoma cells.  Journal Articles
• The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury  Journal Articles
• The role of sphingosine kinase 2 in alcoholic liver disease  Journal Articles
• Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes  Journal Articles
• Treatment with atorvastatin ameliorates hepatic very[ndash ]low-density lipoprotein overproduction in an animal model of insulin resistance, the fructose-fed Syrian golden hamster: Evidence that reduced hypertriglyceridemia is accompanied by improved hepatic insulin sensitivity  Journal Articles
• Upregulation of Krebs cycle and anaerobic glycolysis activity early after onset of liver ischemia  Journal Articles
• Utility of in vitro test methods to assess the activity of xenoestrogens in fish  Journal Articles
• p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor  Journal Articles