Catalytic Domain
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A Complex RNA-Cleaving DNAzyme That Can Efficiently Cleave a Pyrimidine–Pyrimidine Junction Journal Articles
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A divergent Pseudomonas aeruginosa palmitoyltransferase essential for cystic fibrosis‐specific lipid A Journal Articles
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A whole-cell, high-throughput hydrogenase assay to identify factors that modulate [NiFe]-hydrogenase activity Journal Articles
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Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis Journal Articles
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Allosteric Site Variants of Haemophilus influenzae β-Carbonic Anhydrase Journal Articles
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Allosteric modulation of exosite 1 attenuates polyphosphate-catalyzed activation of factor XI by thrombin Journal Articles
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Allosteric pluripotency as revealed by protein kinase A Journal Articles
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Aminoglycoside antibiotic phosphotransferases are also serine protein kinases Journal Articles
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An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition Journal Articles
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Biochemical Properties and Atomic Resolution Structure of a Proteolytically Processed β-Mannanase from Cellulolytic Streptomyces sp. SirexAA-E Journal Articles
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Catalytic Residues and an Electrostatic Sandwich That Promote Enolpyruvyl Shikimate 3-Phosphate Synthase (AroA) Catalysis Journal Articles
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Characterization of a catalytically efficient acidic RNA-cleaving deoxyribozyme Journal Articles
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Characterization of long RNA-cleaving deoxyribozymes with short catalytic cores: the effect of excess sequence elements on the outcome of in vitro selection Journal Articles
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Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal Journal Articles
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Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases Journal Articles
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Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase Journal Articles
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Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis Journal Articles
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Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function Journal Articles
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Definition of an electrostatic relay switch critical for the cAMP‐dependent activation of protein kinase A as revealed by the D170A mutant of RIα Journal Articles
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Differences in prethrombin-1 activation with human or bovine factor Va can be attributed to the heavy chain Journal Articles
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Eliminating Competition: Characterizing and Eliminating Competitive Binding at Separate Sites between DAHP Synthase’s Essential Metal Ion and the Inhibitor DAHP Oxime Journal Articles
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Enzyme Evolution Explained (Sort Of) Journal Articles
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Evidence of Kinetic Control of Ligand Binding and Staged Product Release in MurA (Enolpyruvyl UDP-GlcNAc Synthase)-Catalyzed Reactions, Journal Articles
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Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum Journal Articles
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Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition Journal Articles
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High throughput protease profiling comprehensively defines active site specificity for thrombin and ADAMTS13 Journal Articles
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Identification of a conserved 8 aa insert in the PIP5K protein in the Saccharomycetaceae family of fungi and the molecular dynamics simulations and structural analysis to investigate its potential functional role Journal Articles
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Identification of a diphtheria toxin‐like gene family beyond the Corynebacterium genus Journal Articles
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Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity Pair Journal Articles
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Induction of hTERT Expression and Telomerase Activity by Estrogens in Human Ovary Epithelium Cells Journal Articles
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Investigation of the Anticoagulant Mechanisms of a Covalent Antithrombin-Heparin Complex Journal Articles
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Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms Journal Articles
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Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained Journal Articles
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Lyme Disease Enolpyruvyl-UDP-GlcNAc Synthase: Fosfomycin-Resistant MurA from Borrelia burgdorferi, a Fosfomycin-Sensitive Mutant, and the Catalytic Role of the Active Site Asp Journal Articles
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Mapping the Substrate Recognition Landscapes of Metalloproteases Using Comprehensive Mutagenesis Journal Articles
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Mechanism and Diversity of the Erythromycin Esterase Family of Enzymes Journal Articles
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Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist Journal Articles
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NeuNAc Oxime: A Slow-Binding and Effectively Irreversible Inhibitor of the Sialic Acid Synthase NeuB Journal Articles
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Phylogenetic analysis of the diacylglycerol kinase family of proteins and identification of multiple highly-specific conserved inserts and deletions within the catalytic domain that are distinctive characteristics of different classes of DGK homologs Journal Articles
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Phylogenetic and functional analyses of the cytochrome P450 family 4 Journal Articles
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Probing the Function of Nucleotides in the Catalytic Cores of the 8−17 and 10−23 DNAzymes by Abasic Nucleotide and C3 Spacer Substitutions Journal Articles
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Quantum Mechanics/Molecular Mechanics Strategies for Docking Pose Refinement: Distinguishing between Binders and Decoys in CytochromecPeroxidase Journal Articles
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SANDPUMA: ensemble predictions of nonribosomal peptide chemistry reveal biosynthetic diversity across Actinobacteria Journal Articles
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Signaling at Crossroads: The Dialogue between PDEs and PKA is Spoken in Multiple Languages Journal Articles
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Simple Fluorescent Sensors Engineered with Catalytic DNA ‘MgZ’ Based on a Non-Classic Allosteric Design Journal Articles
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Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I Journal Articles
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Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria Journal Articles
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Structural and Functional Plasticity of Antibiotic Resistance Nucleotidylyltransferases Revealed by Molecular Characterization of Lincosamide Nucleotidylyltransferases Lnu(A) and Lnu(D) Journal Articles
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Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for Antibiotic Adjuvants Journal Articles
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Structure and Function of the Glycopeptide N-methyltransferase MtfA, a Tool for the Biosynthesis of Modified Glycopeptide Antibiotics Journal Articles
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Structure and Mechanism of the Lincosamide Antibiotic Adenylyltransferase LinB Journal Articles
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Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria Journal Articles
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Synthesis and evaluation of inhibitors of E. coli PgaB, a polysaccharide de-N-acetylase involved in biofilm formation Journal Articles
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The Influence of Ser-154, Cys-113, and the Phosphorylated Threonine Residue on the Catalytic Reaction Mechanism of Pin1 Journal Articles
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The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter Journal Articles
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The tamas Gene, Identified as a Mutation That Disrupts Larval Behavior in Drosophila melanogaster, Codes for the Mitochondrial DNA Polymerase Catalytic Subunit (DNApol-γ125) Journal Articles
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Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes Journal Articles
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Transition State Analysis of Enolpyruvylshikimate 3-Phosphate (EPSP) Synthase (AroA)-Catalyzed EPSP Hydrolysis Journal Articles
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Understanding cAMP-Dependent Allostery by NMR Spectroscopy: Comparative Analysis of the EPAC1 cAMP-Binding Domain in Its Apo and cAMP-Bound States Journal Articles
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γT‐S195A thrombin reduces the anticoagulant effects of dabigatran in vitro and in vivo Journal Articles