Catalytic Domain Concept

subject area of

• A Complex RNA-Cleaving DNAzyme That Can Efficiently Cleave a Pyrimidine–Pyrimidine Junction  Journal Articles
• A divergent Pseudomonas aeruginosa palmitoyltransferase essential for cystic fibrosis‐specific lipid A  Journal Articles
• A whole-cell, high-throughput hydrogenase assay to identify factors that modulate [NiFe]-hydrogenase activity  Journal Articles
• Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis  Journal Articles
• Allosteric Site Variants of Haemophilus influenzae β-Carbonic Anhydrase  Journal Articles
• Allosteric modulation of exosite 1 attenuates polyphosphate-catalyzed activation of factor XI by thrombin  Journal Articles
• Allosteric pluripotency as revealed by protein kinase A  Journal Articles
• Aminoglycoside antibiotic phosphotransferases are also serine protein kinases  Journal Articles
• An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition  Journal Articles
• Biochemical Properties and Atomic Resolution Structure of a Proteolytically Processed β-Mannanase from Cellulolytic Streptomyces sp. SirexAA-E  Journal Articles
• Catalytic Residues and an Electrostatic Sandwich That Promote Enolpyruvyl Shikimate 3-Phosphate Synthase (AroA) Catalysis  Journal Articles
• Characterization of a catalytically efficient acidic RNA-cleaving deoxyribozyme  Journal Articles
• Characterization of long RNA-cleaving deoxyribozymes with short catalytic cores: the effect of excess sequence elements on the outcome of in vitro selection  Journal Articles
• Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH.  Journal Articles
• Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal  Journal Articles
• Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases  Journal Articles
• Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase  Journal Articles
• Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis  Journal Articles
• Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function  Journal Articles
• Definition of an electrostatic relay switch critical for the cAMP‐dependent activation of protein kinase A as revealed by the D170A mutant of RIα  Journal Articles
• Differences in prethrombin-1 activation with human or bovine factor Va can be attributed to the heavy chain  Journal Articles
• Eliminating Competition: Characterizing and Eliminating Competitive Binding at Separate Sites between DAHP Synthase’s Essential Metal Ion and the Inhibitor DAHP Oxime  Journal Articles
• Elucidating Evolutionary Mechanisms and Variants of the Hammerhead Ribozyme Using In Vitro Selection  Journal Articles
• Enzyme Evolution Explained (Sort Of)  Journal Articles
• Evidence of Kinetic Control of Ligand Binding and Staged Product Release in MurA (Enolpyruvyl UDP-GlcNAc Synthase)-Catalyzed Reactions,  Journal Articles
• Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum  Journal Articles
• Exosite crosstalk in thrombin.  Journal Articles
• Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition  Journal Articles
• High throughput protease profiling comprehensively defines active site specificity for thrombin and ADAMTS13  Journal Articles
• Identification of a conserved 8 aa insert in the PIP5K protein in the Saccharomycetaceae family of fungi and the molecular dynamics simulations and structural analysis to investigate its potential functional role  Journal Articles
• Identification of a diphtheria toxin‐like gene family beyond the Corynebacterium genus  Journal Articles
• Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity Pair  Journal Articles
• Induction of hTERT Expression and Telomerase Activity by Estrogens in Human Ovary Epithelium Cells  Journal Articles
• Investigation of the Anticoagulant Mechanisms of a Covalent Antithrombin-Heparin Complex  Journal Articles
• Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms  Journal Articles
• Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained  Journal Articles
• Lyme Disease Enolpyruvyl-UDP-GlcNAc Synthase: Fosfomycin-Resistant MurA from Borrelia burgdorferi, a Fosfomycin-Sensitive Mutant, and the Catalytic Role of the Active Site Asp  Journal Articles
• Mapping the Substrate Recognition Landscapes of Metalloproteases Using Comprehensive Mutagenesis  Journal Articles
• Mechanism and Diversity of the Erythromycin Esterase Family of Enzymes  Journal Articles
• Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist  Journal Articles
• NeuNAc Oxime: A Slow-Binding and Effectively Irreversible Inhibitor of the Sialic Acid Synthase NeuB  Journal Articles
• Phylogenetic analysis of the diacylglycerol kinase family of proteins and identification of multiple highly-specific conserved inserts and deletions within the catalytic domain that are distinctive characteristics of different classes of DGK homologs  Journal Articles
• Phylogenetic and functional analyses of the cytochrome P450 family 4  Journal Articles
• Probing the Function of Nucleotides in the Catalytic Cores of the 8−17 and 10−23 DNAzymes by Abasic Nucleotide and C3 Spacer Substitutions  Journal Articles
• Quantum Mechanics/Molecular Mechanics Strategies for Docking Pose Refinement: Distinguishing between Binders and Decoys in CytochromecPeroxidase  Journal Articles
• SANDPUMA: ensemble predictions of nonribosomal peptide chemistry reveal biosynthetic diversity across Actinobacteria  Journal Articles
• Signaling at Crossroads: The Dialogue between PDEs and PKA is Spoken in Multiple Languages  Journal Articles
• Simple Fluorescent Sensors Engineered with Catalytic DNA ‘MgZ’ Based on a Non-Classic Allosteric Design  Journal Articles
• Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I  Journal Articles
• Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria  Journal Articles
• Structural and Functional Plasticity of Antibiotic Resistance Nucleotidylyltransferases Revealed by Molecular Characterization of Lincosamide Nucleotidylyltransferases Lnu(A) and Lnu(D)  Journal Articles
• Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for Antibiotic Adjuvants  Journal Articles
• Structure and Function of the Glycopeptide N-methyltransferase MtfA, a Tool for the Biosynthesis of Modified Glycopeptide Antibiotics  Journal Articles
• Structure and Mechanism of the Lincosamide Antibiotic Adenylyltransferase LinB  Journal Articles
• Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria  Journal Articles
• Synthesis and evaluation of inhibitors of E. coli PgaB, a polysaccharide de-N-acetylase involved in biofilm formation  Journal Articles
• The Influence of Ser-154, Cys-113, and the Phosphorylated Threonine Residue on the Catalytic Reaction Mechanism of Pin1  Journal Articles
• The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter  Journal Articles
• The tamas Gene, Identified as a Mutation That Disrupts Larval Behavior in Drosophila melanogaster, Codes for the Mitochondrial DNA Polymerase Catalytic Subunit (DNApol-γ125)  Journal Articles
• Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes  Journal Articles
• Transition State Analysis of Enolpyruvylshikimate 3-Phosphate (EPSP) Synthase (AroA)-Catalyzed EPSP Hydrolysis  Journal Articles
• Understanding cAMP-Dependent Allostery by NMR Spectroscopy:  Comparative Analysis of the EPAC1 cAMP-Binding Domain in Its Apo and cAMP-Bound States  Journal Articles
• γT‐S195A thrombin reduces the anticoagulant effects of dabigatran in vitro and in vivo  Journal Articles