TOR Serine-Threonine Kinases Concept

subject area of

• A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas  Conferences
• AMP-activated protein kinase (AMPK) beyond metabolism  Journal Articles
• Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis  Journal Articles
• CMV and BKPyV infections in renal transplant recipients receiving an mTOR inhibitor–based regimen versus a cni-based regimen: a systematic review and meta-analysis of randomized, controlled trials  Journal Articles
• Canagliflozin mediates tumor suppression alone and in combination with radiotherapy in non‐small cell lung cancer (NSCLC) through inhibition of HIF‐1α  Journal Articles
• Characterization of Mutational Status, Spheroid Formation, and Drug Response of a New Genomically-Stable Human Ovarian Clear Cell Carcinoma Cell Line, 105C  Journal Articles
• Che‐1‐induced inhibition of mTOR pathway enables stress‐induced autophagy  Journal Articles
• Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts  Journal Articles
• Combined mTOR Inhibition and OX40 Agonism Enhances CD8+ T Cell Memory and Protective Immunity Produced by Recombinant Adenovirus Vaccines  Journal Articles
• Combined mTOR inhibition and OX40 agonism enhances CD8(+) T cell memory and protective immunity produced by recombinant adenovirus vaccines.  Journal Articles
• Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid  Journal Articles
• Drug evaluation: AP-23573--an mTOR inhibitor for the treatment of cancer.  Journal Articles
• E2F7 promotes mammalian target of rapamycin inhibitor resistance in hepatocellular carcinoma after liver transplantation  Journal Articles
• Effects of dietary folic acid supplementation on lactation performance and mammary epithelial cell development of dairy cows and its regulatory mechanism  Journal Articles
• Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases  Journal Articles
• Exercise and the Regulation of Skeletal Muscle Hypertrophy  Journal Articles
• Exercise-specific adaptations in human skeletal muscle: Molecular mechanisms of making muscles fit and mighty.  Journal Articles
• Extracellular Vesicles from BMSCs Prevent Glucocorticoid-Induced BMECs Injury by Regulating Autophagy via the PI3K/Akt/mTOR Pathway.  Journal Articles
• GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4)  Journal Articles
• Human Milk Oligosaccharides Protect against Necrotizing Enterocolitis by Activating Intestinal Cell Differentiation  Journal Articles
• Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion  Journal Articles
• Impaired Growth and Force Production in Skeletal Muscles of Young Partially Pancreatectomized Rats: A Model of Adolescent Type 1 Diabetic Myopathy?  Journal Articles
• Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells  Journal Articles
• Leucine supplementation is anti-atrophic during paradoxical sleep deprivation in rats  Journal Articles
• Leucine-enriched amino acids maintain peripheral mTOR-Rheb localization independent of myofibrillar protein synthesis and mTORC1 signaling postexercise  Journal Articles
• Loss of Hepatocyte-Nuclear-Factor-1α Impacts on Adult Mouse Intestinal Epithelial Cell Growth and Cell Lineages Differentiation  Journal Articles
• Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2–Dependent Phosphatidylinositol 3-Kinase-AKT–Mechanistic Target of Rapamycin Signaling and Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor-C Expression  Journal Articles
• Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death  Journal Articles
• Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition  Journal Articles
• Mutations in TBCK, Encoding TBC1-Domain-Containing Kinase, Lead to a Recognizable Syndrome of Intellectual Disability and Hypotonia  Journal Articles
• Nutrient Sensing and Response Drive Developmental Progression in Caenorhabditis elegans  Journal Articles
• Outcomes of patients with advanced non-clear cell renal cell carcinoma treated with first-line immune checkpoint inhibitor therapy  Journal Articles
• PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer  Journal Articles
• Phase II Study of Temsirolimus in Women With Recurrent or Metastatic Endometrial Cancer: A Trial of the NCIC Clinical Trials Group  Journal Articles
• Phase II study of oral ridaforolimus in women with recurrent or metastatic endometrial cancer  Journal Articles
• Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199)  Journal Articles
• Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells  Journal Articles
• Postexercise Dietary Protein Strategies to Maximize Skeletal Muscle Repair and Remodeling in Masters Endurance Athletes: A Review  Journal Articles
• Protein Ingestion Increases Myofibrillar Protein Synthesis after Concurrent Exercise  Journal Articles
• Protein–Leucine Fed Dose Effects on Muscle Protein Synthesis after Endurance Exercise  Journal Articles
• Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise  Journal Articles
• Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise  Journal Articles
• Resistance exercise decreases eIF2Bε phosphorylation and potentiates the feeding-induced stimulation of p70^S6K1 and rpS6 in young men  Journal Articles
• Resistance exercise enhances mTOR and MAPK signalling in human muscle over that seen at rest after bolus protein ingestion  Journal Articles
• Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle  Journal Articles
• Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways  Journal Articles
• Salicylate enhances the response of prostate cancer to radiotherapy  Journal Articles
• Sirolimus and mTORC1: centre stage in the story of what makes muscles bigger?  Journal Articles
• Statins activate the NLRP3 inflammasome and impair insulin signaling via p38 and mTOR  Journal Articles
• TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma  Journal Articles
• The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression  Journal Articles
• The Genetics of Tuberous Sclerosis Complex and Related mTORopathies: Current Understanding and Future Directions  Journal Articles
• The effect of mTOR inhibition on obstructive hydrocephalus in patients with tuberous sclerosis complex (TSC) related subependymal giant cell astrocytoma (SEGA)  Journal Articles
• The mTORC Pathway in the Antiphospholipid Syndrome  Journal Articles
• To Elucidate the Inhibition of Excessive Autophagy of <i>Rhodiola crenulata</i> on Exhaustive Exercise-Induced Skeletal Muscle Injury by Combined Network Pharmacology and Molecular Docking  Journal Articles
• Trained Integrated Postexercise Myofibrillar Protein Synthesis Rates Correlate with Hypertrophy in Young Males and Females  Journal Articles
• Transcriptome and translational signaling following endurance exercise in trained skeletal muscle: impact of dietary protein  Journal Articles
• Uncoupling of Pro- and Anti-Inflammatory Properties of Staphylococcus aureus  Journal Articles
• p53: The pivot between cell cycle arrest and senescence  Journal Articles