Journal article
Impaired Growth and Force Production in Skeletal Muscles of Young Partially Pancreatectomized Rats: A Model of Adolescent Type 1 Diabetic Myopathy?
Abstract
This present study investigated the temporal effects of type 1 diabetes mellitus (T1DM) on adolescent skeletal muscle growth, morphology and contractile properties using a 90% partial pancreatecomy (Px) model of the disease. Four week-old male Sprague-Dawley rats were randomly assigned to Px (n = 25) or Sham (n = 24) surgery groups and euthanized at 4 or 8 weeks following an in situ assessment of muscle force production. Compared to Shams, Px …
Authors
Gordon CS; Serino AS; Krause MP; Campbell JE; Cafarelli E; Adegoke OAJ; Hawke TJ; Riddell MC
Journal
PLOS ONE, Vol. 5, No. 11,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0014032
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAnalgesicsAnimalsDiabetes Mellitus, Type 1Disease Models, AnimalHumansKetamineMaleMuscle FatigueMuscle Fibers, SkeletalMuscle, SkeletalMuscular DiseasesPancreatectomyRandom AllocationRatsRats, Sprague-DawleySignal TransductionSuccinate DehydrogenaseTOR Serine-Threonine KinasesUbiquitinationXylazine