Journal article
Combined mTOR inhibition and OX40 agonism enhances CD8(+) T cell memory and protective immunity produced by recombinant adenovirus vaccines.
Abstract
The memory CD8(+) T cell population elicited by immunization with recombinant human adenovirus serotype 5 (rHuAd5) vaccines is composed primarily of effector and effector memory cells (T(EM)) with limited polyfunctionality. In this study, we investigated whether treatment with immunomodulators could enhance and/or redistribute the CD8(+) memory population elicited by rHuAd5. Vaccination in combination with both rapamycin (to modulate …
Authors
Bassett JD; Swift SL; VanSeggelen H; Hammill JA; McGray AJR; Evelegh C; Wan Y; Bramson JL
Journal
Mol Ther, Vol. 20, No. 4, pp. 860–869
Publication Date
April 2012
DOI
10.1038/mt.2011.281