Journal article
The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression
Abstract
The majority of newly diagnosed prostate cancers are slow growing, with a long natural life history. Yet a subset can metastasize with lethal consequences. We reconstructed the phylogenies of 293 localized prostate tumors linked to clinical outcome data. Multiple subclones were detected in 59% of patients, and specific subclonal architectures associate with adverse clinicopathological features. Early tumor development is characterized by point …
Authors
Espiritu SMG; Liu LY; Rubanova Y; Bhandari V; Holgersen EM; Szyca LM; Fox NS; Chua MLK; Yamaguchi TN; Heisler LE
Journal
Cell, Vol. 173, No. 4, pp. 1003–1013.e15
Publisher
Elsevier
Publication Date
May 2018
DOI
10.1016/j.cell.2018.03.029
ISSN
0092-8674
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Biomarkers, TumorHigh-Throughput Nucleotide SequencingHomeodomain ProteinsHumansMaleNeoplasm GradingNeoplasm Recurrence, LocalPolymorphism, Single NucleotideProportional Hazards ModelsProspective StudiesProstatic NeoplasmsRetinoblastoma Binding ProteinsTOR Serine-Threonine KinasesTranscription FactorsUbiquitin-Protein Ligases