Journal article
Purine and pyrimidine nucleotides activate distinct signalling pathways in PC12 cells
Abstract
The role of extracellular nucleotides in intracellular signalling and neurosecretion was assessed in PC12 cells. Activation of phospholipase C and increased [Ca2+]i were mediated by purinoceptors with an agonist potency profile, ATP approximately UTP > 2-methylthioadenosine triphosphate (2-MeSATP), typical of P2U. ATP also evoked a rapid acidification followed by a more gradual alkalinization (measured with …
Authors
De Souza LR; Moore H; Raha S; Reed JK
Journal
Journal of Neuroscience Research, Vol. 41, No. 6, pp. 753–763
Publisher
Wiley
Publication Date
August 15, 1995
DOI
10.1002/jnr.490410606
ISSN
0360-4012