Journal article
Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist
Abstract
BACKGROUND: Endometriosis is a chronic, estrogen-dependent condition that causes dysmenorrhea and pelvic pain. Elagolix, an oral, nonpeptide, gonadotropin-releasing hormone (GnRH) antagonist, produced partial to nearly full estrogen suppression in previous studies.
METHODS: We performed two similar, double-blind, randomized, 6-month phase 3 trials (Elaris Endometriosis I and II [EM-I and EM-II]) to evaluate the effects of two doses of elagolix …
Authors
Taylor HS; Giudice LC; Lessey BA; Abrao MS; Kotarski J; Archer DF; Diamond MP; Surrey E; Johnson NP; Watts NB
Journal
The New England Journal of Medicine, Vol. 377, No. 1, pp. 28–40
Publisher
Massachusetts Medical Society
Publication Date
July 6, 2017
DOI
10.1056/nejmoa1700089
ISSN
0028-4793